Zobrazeno 1 - 10
of 192
pro vyhledávání: '"C, Debouck"'
Autor:
C. Debouck, B. Metcalf
Publikováno v:
Annual Review of Pharmacology and Toxicology. 40:193-208
High-throughput gene sequencing has revolutionized the process used to identify novel molecular targets for drug discovery. Thousands of new gene sequences have been generated but only a limited number of these can be converted into validated targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ff6391745be8f55758ab1a075be8c1
https://doi.org/10.1146/annurev.pharmtox.40.1.193
https://doi.org/10.1146/annurev.pharmtox.40.1.193
Publikováno v:
Journal of Biological Chemistry. 267:22770-22778
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9610c90383aa80a2ba12a8cc354bbd50
https://doi.org/10.1016/s0021-9258(18)50014-4
https://doi.org/10.1016/s0021-9258(18)50014-4
Autor:
R, McGinnis, F, Child, S, Clayton, S, Davies, W, Lenney, T, Illig, M, Wjst, N, Spurr, C, Debouck, A H, Hajeer, W E R, Ollier, R, Strange, A A, Fryer
Publikováno v:
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 29(6)
English and German nuclear families containing multiple asthmatic children and asthmatic parents were analysed to retest a recently reported association between resistance to asthma and the delta32 allele of chemokine receptor 5 (CCR5). Analysis of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a62c0aaf91f3e1861c205f8b9029e3f8
https://pubmed.ncbi.nlm.nih.gov/12437612
https://pubmed.ncbi.nlm.nih.gov/12437612
The 80's loop (residues 78 to 85) is important for the differential activity of retroviral proteases
Publikováno v:
Journal of molecular biology. 267(3)
The abundance of structural data available for retroviral proteases affords a unique opportunity to investigate structure activity relationships. Our approach attempts to genetically engineer an HIV (human immunodeficiency virus)-1 protease that is f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18c0c615a8cb52dfc7acfe9e00640b13
https://pubmed.ncbi.nlm.nih.gov/9126830
https://pubmed.ncbi.nlm.nih.gov/9126830
Autor:
P B, Taylor, J S, Culp, C, Debouck, R K, Johnson, A D, Patil, D J, Woolf, I, Brooks, R P, Hertzberg
Publikováno v:
The Journal of biological chemistry. 269(9)
Inophyllums are novel non-nucleoside inhibitors of human immunodeficiency virus (HIV) type 1 reverse transcriptase identified through an enzyme screening program and isolated from the plant Calophyllum inophyllum. The kinetics of reverse transcriptas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fab018372cb5e00805119baf316b8258
https://pubmed.ncbi.nlm.nih.gov/7509800
https://pubmed.ncbi.nlm.nih.gov/7509800
Autor:
J, Stebbins, C, Debouck
Publikováno v:
Methods in enzymology. 241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a317fe9a5e42b4a18958b3603ed116de
https://pubmed.ncbi.nlm.nih.gov/7854184
https://pubmed.ncbi.nlm.nih.gov/7854184
Autor:
S S, Abdel-Meguid, B, Zhao, K H, Murthy, E, Winborne, J K, Choi, R L, DesJarlais, M D, Minnich, J S, Culp, C, Debouck, T A, Tomaszek
Publikováno v:
Biochemistry. 32(31)
The human immunodeficiency virus type 1 (HIV-1) protease is a potential target of acquired immune deficiency syndrome (AIDS) therapy. A highly potent, perfectly symmetrical phosphinate inhibitor of this enzyme, SB204144, has been synthesized. It is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977ff3a265eaf6a31672893596b3b42f
https://pubmed.ncbi.nlm.nih.gov/8347601
https://pubmed.ncbi.nlm.nih.gov/8347601
Identification and characterization of novel low-temperature-inducible promoters of Escherichia coli
Publikováno v:
Journal of bacteriology. 174(24)
Escherichia coli promoters that are more active at low temperature (15 to 20 degrees C) than at 37 degrees C were identified by using the transposon Tn5-lac to generate promoter fusions expressing beta-galactosidase (beta-Gal). Tn5-lac insertions tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b9001ecdb7cc71a38a4db724b72f9b
https://pubmed.ncbi.nlm.nih.gov/1334067
https://pubmed.ncbi.nlm.nih.gov/1334067
Publikováno v:
Circulation research. 69(3)
Modulation of the biosynthesis of the vasoconstrictor peptide endothelin was studied in cultured endothelial cells. Immunoreactive endothelin (irET) levels were significantly elevated in conditioned medium from bovine pulmonary artery endothelial (BP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b751378afd0828bfdc938078ca04f8a9
https://pubmed.ncbi.nlm.nih.gov/1873876
https://pubmed.ncbi.nlm.nih.gov/1873876
Publikováno v:
The New biologist. 3(8)
The Tat protein of the human immunodeficiency virus type 1 (HIV-1) is required for efficient viral gene expression. By means of mutational analyses, several domains of the Tat protein that are required for complete activation of HIV-1 gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f0800be7ebff60f6a14001d11b4fa19
https://pubmed.ncbi.nlm.nih.gov/1931822
https://pubmed.ncbi.nlm.nih.gov/1931822