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Akademický článek

Altered neuronal lactate dehydrogenase A expression affects cognition in a sex- and age-dependent manner

Autor: Ariel K. Frame, Jessica L. Sinka, Marc Courchesne, Rashad A. Muhammad, Sandra Grahovac-Nemeth, Mark A. Bernards, Robert Bartha, Robert C. Cumming

Publikováno v: iScience, Vol 27, Iss 7, Pp 110342- (2024)

Summary: The astrocyte-neuron lactate shuttle (ANLS) model posits that astrocyte-generated lactate is transported to neurons to fuel memory processes. However, neurons express high levels of lactate dehydrogenase A (LDHA), the rate-limiting enzyme of

Externí odkaz: https://doaj.org/article/3ed75eb25af84bd4acc33d15401d1d63

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Akademický článek

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Akademický článek

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Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies

Autor: Ariel K. Frame, J. Wesley Robinson, Nader H. Mahmoudzadeh, Jason M. Tennessen, Anne F. Simon, Robert C. Cumming

The astrocyte-neuron lactate shuttle hypothesis posits that glial-generated lactate is transported to neurons to fuel metabolic processes required for long-term memory. Although studies in vertebrates have revealed that lactate shuttling is important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16118bebcaffe599c7b5d11c59eade28
https://doi.org/10.1101/2022.10.19.512981

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Using the urea cycle to shift astrocytes from harmful to helpful in Alzheimer's disease

Autor: Ariel K. Frame, Robert C. Cumming

Publikováno v: Cell metabolism. 34(8)

Astrocytes are brain cells that react to Alzheimer's disease pathology in ways that can have either beneficial or detrimental effects. In this issue of Cell Metabolism, Ju et al. outline a novel strategy for coercing astrocytes to a neuroprotective s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1625b30681321c5d1bc7b0386f3bb61f
https://pubmed.ncbi.nlm.nih.gov/35738259

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Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster

Autor: David A. Hendrix, Robert C. Cumming, Patrick N. Reardon, Dani M Long, Ariel K. Frame, Jadwiga M. Giebultowicz, Doris Kretzschmar

Publikováno v: Aging (Albany NY)
Paediatrics Publications

Lactate dehydrogenase (LDH) catalyzes the conversion of glycolysis-derived pyruvate to lactate. Lactate has been shown to play key roles in brain energetics and memory formation. However, lactate levels are elevated in aging and Alzheimer's disease p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873fb6b30eb026a9097ae185b5e6bcd7
http://europepmc.org/articles/PMC7346061

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Determining the role of lactate metabolism on age‐dependent memory decline and neurodegeneration in Drosophila melanogaster

Autor: Anne Simon, Ariel K. Frame, Robert C. Cumming

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4eb631c8a77a648a7d06e0de08ec5f1
https://doi.org/10.1002/alz.037313

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Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts

Autor: Dean H. Betts, Robert C. Cumming, Alexandra M. Kozlov, Asad Lone

Publikováno v: Paediatrics Publications
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports

Recent evidence has emerged that cancer cells can use various metabolites as fuel sources. Restricting cultured cancer cells to sole metabolite fuel sources can promote metabolic changes leading to enhanced glycolysis or mitochondrial OXPHOS. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca41807b91a5038e16629f326eaf1b5
https://doi.org/10.1038/s41598-020-65193-9

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Abnormal Social Interactions in a

Autor: Ryley T, Yost, J Wesley, Robinson, Carling M, Baxter, Andrew M, Scott, Liam P, Brown, M Sol, Aletta, Ramtin, Hakimjavadi, Asad, Lone, Robert C, Cumming, Reuven, Dukas, Brian, Mozer, Anne F, Simon

Publikováno v: International Journal of Molecular Sciences

Social interactions are typically impaired in neuropsychiatric disorders such as autism, for which the genetic underpinnings are very complex. Social interactions can be modeled by analysis of behaviors, including social spacing, sociability, and agg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c4bb65269b8eab2af992074b6fb9e53f
https://pubmed.ncbi.nlm.nih.gov/32610435

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Importance of collecting data on socioeconomic determinants from the early stage of the COVID-19 outbreak onwards

Autor: Robert C. Cumming, Cyrille Delpierre, Michelle Kelly-Irving, Saman Khalatbari-Soltani

Publikováno v: Journal of Epidemiology and Community Health
Journal of Epidemiology and Community Health, 2020, pp.jech-2020-214297. ⟨10.1136/jech-2020-214297⟩

International audience; Disadvantaged socioeconomic position (SEP) is widely associated with disease and mortality, and there is no reason to think this will not be the case for the newly emerged coronavirus disease 2019 (COVID-19) that has reached a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50932748d1974f95ca81c9bbbb1fb2c7
https://hal.science/hal-03608638/document

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