Zobrazeno 1 - 10
of 105
pro vyhledávání: '"C, Coutsogeorgopoulos"'
Publikováno v:
Molecular pharmacology. 53(6)
A detailed kinetic study was carried out on the inhibitory mechanisms of two eukaryotic peptidyltransferase drugs (I), anisomycin and sparsomycin. In an in vitro system from rabbit reticulocytes, AcPhe-puromycin is produced in a pseudo-first-order re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12306df0b5ad48464597ba2635544c65
https://pubmed.ncbi.nlm.nih.gov/9614213
https://pubmed.ncbi.nlm.nih.gov/9614213
Autor:
S, Kallia-Raftopoulos, D, Synetos, H C, Ottenheijm, L A, van den Broek, C, Coutsogeorgopoulos
Publikováno v:
Molecular pharmacology. 49(6)
The ability of several sparsomycin analogues to inhibit peptide bond formation was studied in vitro. Peptide bonds are formed between puromycin (S) and the acetylPhe-tRNA of acetylPhe-tRNA/70 S ribosome/poly(U) complex (complex C), according to the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9908b5168b985f4289c6aabf5873c6a8
https://pubmed.ncbi.nlm.nih.gov/8649347
https://pubmed.ncbi.nlm.nih.gov/8649347
Publikováno v:
Molecular pharmacology. 46(5)
We have investigated the inhibition of peptide bond formation by the antibiotic lincomycin, at 150 mM NH4Cl. We have used an in vitro system in which a ribosomal ternary complex, the acetyl[3H] phenylalanine-tRNA-70 S ribosome-poly(U) complex (comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ae8ca45ac5a9580622a7fa1053f0bc8
https://pubmed.ncbi.nlm.nih.gov/7969063
https://pubmed.ncbi.nlm.nih.gov/7969063
Publikováno v:
Journal of Medicinal Chemistry. 18:771-776
Seventeen structural analogs of gougerotin have been compared with the parent compound as inhibitors of the growh of E. coli B and as inhibitors of N-acetylphenylalanylpuromycin formation. The analogs comprise compounds with (1) an intact sarcosyl-D-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::538a81d9a918f2c797126201e6926c17
https://doi.org/10.1021/jm00242a001
https://doi.org/10.1021/jm00242a001
Inhibitors of protein synthesis V Irreversible interaction of antibiotics with an initiation complex
Publikováno v:
Nucleic Acids Research. 2:1053-1072
The initiation complex (t-complex) formed in a cell-free system (E. coli) from Ac-Phe-tRNA, poly(U) and washed ribosomes in the presence of initiation factors (ribosomal wash) and GTP, contains the Ac-Phe-tRNA bound quantitatively in a puromycin-reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c619c98547e4411c1737edb6ff437ca5
https://doi.org/10.1093/nar/2.7.1053
https://doi.org/10.1093/nar/2.7.1053
Autor:
H. G. Khorana, C. Coutsogeorgopoulos
Publikováno v:
Journal of the American Chemical Society. 86:2926-2932
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d69ffd707c92b3a8000d17b50cc32ab9
https://doi.org/10.1021/ja01068a032
https://doi.org/10.1021/ja01068a032
Publikováno v:
Biochemical and Biophysical Research Communications. 20:129-134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea07529d34022886fabcf68e44d916c
https://doi.org/10.1016/0006-291x(65)90335-9
https://doi.org/10.1016/0006-291x(65)90335-9
Publikováno v:
Biochemical and Biophysical Research Communications. 5:477-480
An enzyme fraction from calf thymus nuclei which incorporates single ribonucleotides into terminal positions of DNA has been described (1, 2, 3). It has been found that this same enzyme fraction (referred to in this communication as ‘nuclear enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f0a378b5e724d860c1e4c187931ff6f
https://doi.org/10.1016/0006-291x(61)90099-7
https://doi.org/10.1016/0006-291x(61)90099-7
Autor:
C. Coutsogeorgopoulos, R. Fico
Publikováno v:
Biochemical and Biophysical Research Communications. 47:645-651
The reaction of N-Acetyl-phenylalanyl-t-RNA with E.coli ribosomes in the presence of poly Uridylic acid, guanosine 5′-triphosphate, and initiation factors (ribosomal wash), leads to the formation of N-Acetyl-phenylalanyl-RNA-ribosome-poly Uridylic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888a0fe3f22803655c97b0d80e5ec7ba
https://doi.org/10.1016/0006-291x(72)90927-8
https://doi.org/10.1016/0006-291x(72)90927-8
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects. 55:639-650
The purification of an enzyme fraction from calf-thymus nuclei catalyzing a limited incorporation of deoxyribonucleotides into the terminal positions of DNA has been described. The enzyme studied is apparently distinct from DNA polymerase. The same e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9b6d7d9dc0e051d431d2d3006cef06
https://doi.org/10.1016/0926-6550(62)90313-4
https://doi.org/10.1016/0926-6550(62)90313-4