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Akademický článek

Maternal Deprivation Increases Anxiety- and Depressive-Like Behaviors in an Age-Dependent Fashion and Reduces Neuropeptide Y Expression in the Amygdala and Hippocampus of Male and Female Young Adult Rats

Autor: Alexandra S. Miragaia, Guilherme S. de Oliveira Wertheimer, Amanda C. Consoli, Rafael Cabbia, Beatriz M. Longo, Carlos E. N. Girardi, Deborah Suchecki

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 12 (2018)

Maternal deprivation for 24 h produces an immediate increase in basal and stress-induced corticosterone (CORT) secretion. Given the impact of elevated CORT levels on brain development, the goal of the present study was to characterize the effects of

Externí odkaz: https://doaj.org/article/95bceab12ff447fbab100a5bac859ba0

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Acute manganese exposure impairs glutamatergic function in a young mouse model of Alzheimer's disease

Autor: Brittany D. Spitznagel, Rebecca A. Buchanan, David C. Consoli, Megan K. Thibert, Aaron B. Bowman, William P. Nobis, Fiona E. Harrison

Publikováno v: Neurotoxicology.

Manganese (Mn) is an essential metal that serves as a cofactor for metalloenzymes important in moderating oxidative stress and the glutamate/glutamine cycle. Mn is typically obtained through the diet, but toxic overexposure can occur through other en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0f3a6dd147f06f4e6f556dffc568c7
https://pubmed.ncbi.nlm.nih.gov/36621467

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Akademický článek

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Akademický článek

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Akademický článek

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Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis

Autor: David C. Consoli, Brittany D. Spitznagel, Benjamin M. Owen, Hakmook Kang, Shawniqua Williams Roberson, Pratik Pandharipande, E. Wesley Ely, William P. Nobis, Julie A. Bastarache, Fiona E. Harrison

Publikováno v: Brain, behavior, and immunity. 107

Sepsis and systemic inflammation are often accompanied by severe encephalopathy, sleep disruption and delirium that strongly correlate with poor clinical outcomes including long-term cognitive deficits. The cardinal manifestations of delirium are flu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f17c47e86c40d3a951eabbc48b5092d
https://pubmed.ncbi.nlm.nih.gov/36243287

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Ascorbate deficiency decreases dopamine release in gulo –/– and APP/PSEN1 mice

Autor: Aaron B. Bowman, David C. Consoli, Fiona E. Harrison, Lillian J. Brady, Erin S. Calipari

Publikováno v: Journal of Neurochemistry. 157:656-665

Dopamine (DA) has important roles in learning, memory, and motivational processes and is highly susceptible to oxidation. In addition to dementia, Alzheimer's disease (AD) patients frequently exhibit decreased motivation, anhedonia, and sleep disorde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a81309cc78f8202baa0dd22310684e7
https://doi.org/10.1111/jnc.15151

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Ascorbate deficiency decreases dopamine release in gulo

Autor: David C, Consoli, Lillian J, Brady, Aaron B, Bowman, Erin S, Calipari, Fiona E, Harrison

Publikováno v: J Neurochem

Dopamine (DA) has important roles in learning, memory, and motivational processes and is highly susceptible to oxidation. In addition to dementia, Alzheimer’s disease (AD) patients frequently exhibit decreased motivation, anhedonia, and sleep disor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f6c6e57f00c4594c16b86fe180fd4b2
https://pubmed.ncbi.nlm.nih.gov/32797675

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A Cecal Slurry Mouse Model of Sepsis Leads to Acute Consumption of Vitamin C in the Brain

Autor: Fiona E. Harrison, Nathan D. Putz, Kelly R Klimo, Jordan J. Jesse, Julie A. Bastarache, Adriana A. Tienda, David C. Consoli

Publikováno v: Nutrients
Nutrients, Vol 12, Iss 4, p 911 (2020)
Volume 12
Issue 4

Vitamin C (ascorbate, ASC) is a critical antioxidant in the body with specific roles in the brain. Despite a recent interest in vitamin C therapies for critical care medicine, little is known about vitamin C regulation during acute inflammation and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b463ea7aa920229f7e326b4483331e3
https://pubmed.ncbi.nlm.nih.gov/32224930

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