Zobrazeno 1 - 10
of 150
pro vyhledávání: '"C, Caswell"'
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background The widespread clinical application of genome-wide sequencing has resulted in many new diagnoses for rare genetic conditions, but testing regularly identifies variants of uncertain significance (VUS). The remarkable rise in the am
Externí odkaz:
https://doaj.org/article/8a18d4fa39a84867a269df47a7e78eaa
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Brucella spp. are Gram-negative bacteria that naturally infect a variety of domesticated and wild animals, often resulting in abortions and sterility. Humans exposed to these animals or animal products can also develop debilitating, flu-like disease.
Externí odkaz:
https://doaj.org/article/17567ba6c7c24aa8b15e5abe91febf34
Autor:
Alyssa B. Helms, Orsolya Balogh, Rebecca Franklin-Guild, Kevin Lahmers, Clayton C. Caswell, Julie T. Cecere
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
Brucellosis is a zoonotic disease caused by a Gram-negative coccobacillus. There are four Brucella strains of zoonotic importance in our domestic species, subdivided by their culture phenotypes: Brucella abortus (B. abortus), B. melitensis, B. suis (
Externí odkaz:
https://doaj.org/article/18605db519df4846a50dd5de9b9592a6
Autor:
Emma Wakeling, Meriel McEntagart, Michael Bruccoleri, Charles Shaw-Smith, Karen L. Stals, Matthew Wakeling, Angela Barnicoat, Clare Beesley, Andrea K. Hanson-Kahn, Mary Kukolich, David A. Stevenson, Philippe M. Campeau, Sian Ellard, Sarah H. Elsea, Xiang-Jiao Yang, Richard C. Caswell
Publikováno v:
HGG Advances, Vol 2, Iss 1, Pp 100015- (2021)
Summary: Histone deacetylases play crucial roles in the regulation of chromatin structure and gene expression in the eukaryotic cell, and disruption of their activity causes a wide range of developmental disorders in humans. Loss-of-function alleles
Externí odkaz:
https://doaj.org/article/246a7dacb117428c8733e2f639e82ae3
Autor:
James A Budnick, Lauren M Sheehan, Angela H Benton, Joshua E Pitzer, Lin Kang, Pawel Michalak, R Martin Roop, Clayton C Caswell
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237371 (2020)
The neurotransmitter gamma-aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the human brain; however, it is becoming more evident that this non-proteinogenic amino acid plays multiple physiological roles in biology. In the
Externí odkaz:
https://doaj.org/article/97bb7382aa27418b8160c18821ea45e1
Publikováno v:
Pathogenesis of Bacterial Infections in Animals. :361-375
Autor:
Danielle L. Porier, Sarah N. Wilson, Dawn I. Auguste, Andrew Leber, Sheryl Coutermarsh-Ott, Irving C. Allen, Clayton C. Caswell, James A. Budnick, Josep Bassaganya-Riera, Raquel Hontecillas, James Weger-Lucarelli, Scott C. Weaver, Albert J. Auguste
Publikováno v:
Vaccines, Vol 9, Iss 10, p 1142 (2021)
Vaccination remains critical for viral disease outbreak prevention and control, but conventional vaccine development typically involves trade-offs between safety and immunogenicity. We used a recently discovered insect-specific flavivirus as a vector
Externí odkaz:
https://doaj.org/article/38a97a5ba5ee4c09ac815d6d7477d27c
Autor:
Daniel E. Rothschild, Yao Zhang, Na Diao, Christina K. Lee, Keqiang Chen, Clayton C. Caswell, Daniel J. Slade, Richard F. Helm, Tanya LeRoith, Liwu Li, Irving C. Allen
Publikováno v:
EBioMedicine, Vol 15, Iss C, Pp 36-47 (2017)
Aberrant inflammation is a hallmark of inflammatory bowel disease (IBD) and colorectal cancer. IRAK-M is a critical negative regulator of TLR signaling and overzealous inflammation. Here we utilize data from human studies and Irak-m−/− mice to el
Externí odkaz:
https://doaj.org/article/1d4998e8db6b4e1c84ee8dca4b4b51fc
Autor:
Juselyn D. Tupik, Sheryl L. Coutermarsh-Ott, Angela H. Benton, Kellie A. King, Hanna D. Kiryluk, Clayton C. Caswell, Irving C. Allen
Publikováno v:
Pathogens, Vol 9, Iss 12, p 1008 (2020)
Brucella abortus is a zoonotic pathogen that causes brucellosis. Because of Brucella’s unique LPS layer and intracellular localization predominately within macrophages, it can often evade immune detection. However, pattern recognition receptors are
Externí odkaz:
https://doaj.org/article/c6466b597cbd498d9f40423e03838b0a
Publikováno v:
European Journal of Medical Genetics. 66:104768