Zobrazeno 1 - 10
of 141
pro vyhledávání: '"C, Capell"'
Autor:
Shivam A. Zaver, Mrinal K. Sarkar, Shaun Egolf, Jonathan Zou, Afua Tiwaa, Brian C. Capell, Johann E. Gudjonsson, Cory L. Simpson
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Mutation of the ATP2A2 gene encoding sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2) was linked to Darier disease more than 2 decades ago; however, there remain no targeted therapies for this disorder causing recurrent skin blistering and infec
Externí odkaz:
https://doaj.org/article/832d0a2141544a16a129708eb2dfa1a4
Autor:
Christopher A. Natale, Jinyang Li, Jason R. Pitarresi, Robert J. Norgard, Tzvete Dentchev, Brian C. Capell, John T. Seykora, Ben Z. Stanger, Todd W. Ridky
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 868-880.e1 (2020)
Background & Aims: Female sex is associated with lower incidence and improved clinical outcomes for most cancer types including pancreatic ductal adenocarcinoma (PDAC). The mechanistic basis for this sex difference is unknown. We hypothesized that es
Externí odkaz:
https://doaj.org/article/946b93cabff04f0896338d86cd960e53
Autor:
Shaun Egolf, Yann Aubert, Miriam Doepner, Amy Anderson, Alexandra Maldonado-Lopez, Gina Pacella, Jessica Lee, Eun Kyung Ko, Jonathan Zou, Yemin Lan, Cory L. Simpson, Todd Ridky, Brian C. Capell
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 1981-1992.e7 (2019)
Summary: Self-renewing somatic tissues depend upon the proper balance of chromatin-modifying enzymes to coordinate progenitor cell maintenance and differentiation, disruption of which can promote carcinogenesis. As a result, drugs targeting the epige
Externí odkaz:
https://doaj.org/article/e7262a9cac514805a2eb483556aa423b
Autor:
Luke T. Izzo, Sophie Trefely, Christina Demetriadou, Jack M. Drummond, Takuya Mizukami, Nina Kuprasertkul, Aimee T. Farria, Phuong T. T. Nguyen, Nivitha Murali, Lauren Reich, Daniel S. Kantner, Joshua Shaffer, Hayley Affronti, Alessandro Carrer, Andrew Andrews, Brian C. Capell, Nathaniel W. Snyder, Kathryn E. Wellen
Publikováno v:
Science Advances. 9
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate and acetate, which are processed to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7356994fc12704f2e3379bbefe59fadb
https://doi.org/10.1126/sciadv.adf0115
https://doi.org/10.1126/sciadv.adf0115
Autor:
Todd W. Ridky, John T. Seykora, Meenhard Herlyn, Shelley L. Berger, Tzvete Dentchev, Brian C. Capell, Elizabeth K. Duperret, Christopher A. Natale, Vihang Nakhate, Kevin Liu, Andrew S. McNeal
Supplementary Figure S1. p15, p16, and Ki-67 expression in a benign BRAF(V600E) nevus. Supplementary Figure S2. Active CDK4 reverses BRAF(V600E)-mediated melanocyte growth arrest. Supplementary Figure S3. BRAF(V600E), p15, and p16 expression in norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e60c2a32123f4e471453b170e02d69
https://doi.org/10.1158/2159-8290.22530162.v1
https://doi.org/10.1158/2159-8290.22530162.v1
Autor:
Todd W. Ridky, John T. Seykora, Meenhard Herlyn, Shelley L. Berger, Tzvete Dentchev, Brian C. Capell, Elizabeth K. Duperret, Christopher A. Natale, Vihang Nakhate, Kevin Liu, Andrew S. McNeal
Deletion of the entire CDKN2B–CDKN2A gene cluster is among the most common genetic events in cancer. The tumor-promoting effects are generally attributed to loss of CDKN2A-encoded p16 and p14ARF tumor suppressors. The degree to which the associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8234bb880dc7f2f566809e0eb320e952
https://doi.org/10.1158/2159-8290.c.6546117.v1
https://doi.org/10.1158/2159-8290.c.6546117.v1
Autor:
Luca Busino, Brian C. Capell, Kojo S.J. Elenitoba-Johnson, Kathryn E. Wellen, Sydney Campbell, Venkatesha Basrur, Özlem Önder, Delphine Rolland, Nan Zhou, Rizwan Saffie
Supplementary Data (Fig. S1- S6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011f2bd1ec4fda3c1aa369108131a7b7
https://doi.org/10.1158/0008-5472.22422930
https://doi.org/10.1158/0008-5472.22422930
Data from FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells
Autor:
Luca Busino, Brian C. Capell, Kojo S.J. Elenitoba-Johnson, Kathryn E. Wellen, Sydney Campbell, Venkatesha Basrur, Özlem Önder, Delphine Rolland, Nan Zhou, Rizwan Saffie
Mature B-cell neoplasms are the fifth most common neoplasm. Due to significant heterogeneity at the clinical and genetic levels, current therapies for these cancers fail to provide long-term cures. The clinical success of proteasome inhibition for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b33d0396201754d24223a50b8cad0731
https://doi.org/10.1158/0008-5472.c.6511377.v1
https://doi.org/10.1158/0008-5472.c.6511377.v1
Autor:
Alexandra M. Maldonado López, Sijia Huang, Gina Pacella, Eun Kyung Ko, Hui Shen, Julian Stoute, Morgan Sinkfield, Amy Anderson, Stephen Prouty, Hua-Bing Li, John T. Seykora, Kathy Fange Liu, Brian C. Capell
The balance between epithelial stemness and differentiation requires the precise regulation of gene expression programs. Epitranscriptomic RNA modifications have been implicated in both epithelial development as well as cancers. However, the underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d46e4282bb7b0289b83e7cff1f20caf
https://doi.org/10.1101/2022.12.14.520484
https://doi.org/10.1101/2022.12.14.520484