Výsledky vyhledávání

Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration

Autor: Peter Hoffmann, Mark D. Bunting, Ervin E. Kara, Iain Comerford, Sapna Devi, Lynn Tolley, Clifford Young, Cameron R. Bastow, Mark R. Condina, Shaun R. McColl, Duncan R. McKenzie, Scott N. Mueller, Natasha L. Harvey, Ian H. Frazer, Adriana C. Caon

Publikováno v: Proc Natl Acad Sci U S A

Leukocyte homing driven by the chemokine CCL21 is pivotal for adaptive immunity because it controls dendritic cell (DC) and T cell migration through CCR7. ACKR4 scavenges CCL21 and has been shown to play an essential role in DC trafficking at the ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5699a20596e0a5883db90b019f3a1c
https://hdl.handle.net/11541.2/148072

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A Role for Macrophage Inflammatory Protein-3α/CC Chemokine Ligand 20 in Immune Priming During T Cell-Mediated Inflammation of the Central Nervous System

Autor: David O. Willenborg, Adriana C. Caon, Shaun R. McColl, Ian Clark-Lewis, Rachel E. Kohler

Publikováno v: The Journal of Immunology. 170:6298-6306

Chemokines are a family of cytokines that exhibit selective chemoattractant properties for target leukocytes and play a significant role in leukocyte migration. In this study, we have investigated the role of the C-C chemokine, macrophage inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6d4b61f9bea8ee3c778709d561fa03
https://doi.org/10.4049/jimmunol.170.12.6298

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Immunoblotting and sequential lysis protocols for the analysis of tyrosine phosphorylation-dependent signaling

Autor: Caroline Gilbert, Paul H. Naccache, Emmanuelle Rollet-Labelle, Adriana C. Caon

Publikováno v: Journal of Immunological Methods. 271:185-201

In stimulated neutrophils, the majority of tyrosine-phosphorylated proteins are concentrated in Triton X-100 or NP-40 insoluble fractions. Most immunobiochemical studies, whose objective is to study the functional relevance of tyrosine phosphorylatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cbfe0721d41c87abc49802d5abb9d0
https://doi.org/10.1016/s0022-1759(02)00347-2

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Tyrosine phosphorylation in activated human neutrophils. Comparison of the effects of different classes of agonists and identification of the signaling pathways involved

Autor: E Rollet, A C Caon, C J Roberge, N W Liao, S E Malawista, S R McColl, P H Naccache

Publikováno v: The Journal of Immunology. 153:353-363

The tyrosine phosphorylation responses initiated in human neutrophils by soluble and particulate agonists were characterized. Chemotactic factors, hematopoietic growth factors, and inflammatory microcrystals stimulated in a time- and concentration-de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0405bdca3b4ddd87b404748c77f7362d
https://doi.org/10.4049/jimmunol.153.1.353

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Modulation of the activity and subcellular distribution of protein tyrosine kinases in human neutrophils by phorbol esters

Autor: Adriana C. Caon, Murielle Gaudry, Paul H. Naccache

Publikováno v: The FASEB Journal. 7:687-693

Although several tyrosine kinases are present in human neutrophils, little is known regarding the biochemical basis for their activation. We have identified two tyrosine kinase activities in 0.1 and 1% Triton cell extracts of human neutrophils using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc278ef6a4de1f1b8b09785fc8f0a46
https://doi.org/10.1096/fasebj.7.8.7684713

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Pertussis toxin selectively interferes with the responses of the HL-60 human promyelocytic cell line to dimethylsulfoxide

Autor: Shaun R. McColl, Guy Chouinard, Adriana C. Caon, Caroline Gilbert, Paul H. Naccache

Publikováno v: Blood. 78:2534-2541

The effects of pertussis toxin (PT) on the growth and dimethylsulfoxide (Me2SO4)-induced differentiation of the HL-60 human promyelocytic leukemia cell line were tested. Cell growth was quantified by direct cell counts. Cell differentiation was estim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99fed15d5e817c21afa66b8d48f85520
https://doi.org/10.1182/blood.v78.10.2534.2534

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Involvement of tyrosine kinases in the activation of human peripheral blood neutrophils by granulocyte-macrophage colony-stimulating factor

Autor: Shaun R. McColl, Paul H. Naccache, Peggy Ho, Adriana C. Caon, John F. DiPersio

Publikováno v: Blood. 78:1842-1852

The aim of the present study is to evaluate the involvement of human neutrophil tyrosine kinase(s) in the signal transduction mechanism of granulocyte-macrophage colony-stimulating factor (GM-CSF). Stimulation of neutrophils with GM-CSF resulted in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37232b4019d6a06e35d90a0db5de275f
https://doi.org/10.1182/blood.v78.7.1842.1842

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Involvement of tyrosine kinases in the activation of human peripheral blood neutrophils by granulocyte-macrophage colony-stimulating factor

Autor: S R, McColl, J F, DiPersio, A C, Caon, P, Ho, P H, Naccache

Publikováno v: Blood. 78:1842-1852

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c54825ba49bc281191ac9b7e56c829
https://doi.org/10.1182/blood.v78.7.1842.bloodjournal7871842

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