Zobrazeno 1 - 10
of 49
pro vyhledávání: '"C, Cantello"'
Autor:
Nicola C. Stevens, David Haigh, Harshad Kantilal Rami, Barrie C. C. Cantello, Helen C. Birrell, Anantha Ramaswamy, Richard Mark Hindley
Publikováno v:
Tetrahedron: Asymmetry. 10:1335-1351
The synthesis of a new series of potent 2-oxy-3-arylpropanoic acid antihyperglycaemic agents in both racemic and non-racemic form is described. Resolution of racemic acids 1 is accomplished via amide formation with either ( S )-2-phenylglycinol or (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72acc8a320b2f0a4cee3cbd790230eac
https://doi.org/10.1016/s0957-4166(99)00104-4
https://doi.org/10.1016/s0957-4166(99)00104-4
Autor:
David Haigh, Anantha Ramaswamy, Nicola C. Stevens, Barrie C. C. Cantello, Helen C. Birrell, Richard Mark Hindley, R. Curtis Haltiwanger, Drake S. Eggleston
Publikováno v:
Tetrahedron: Asymmetry. 10:1353-1367
Boron-mediated asymmetric aldol reactions of substituted benzaldehyde 5 with 2-oxyethanoyloxazolidinones 4a–e, containing electron withdrawing, chelating, and bulky alkoxy and aryloxy groups, gave variable yields of syn-aldol adducts 6a–e in high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e5330a14af922c735dc870d5e894ad
https://doi.org/10.1016/s0957-4166(99)00112-3
https://doi.org/10.1016/s0957-4166(99)00112-3
Autor:
David Kenneth Dean, P.J. Coyle, Stephen A. Smith, Harshad Kantilal Rami, Ivan Leo Pinto, Michael A. Cawthorne, Richard Mark Hindley, Derek R. Buckle, Barrie C. C. Cantello, Carolyn A. Lister, David Haigh, Andrew Faller, L. J. Jefcott, D.G. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2127-2130
The thiazolidine-2,4-dione ring of insulin sensitising antidiabetic agents can be replaced by α-acyl-, α-alkyl- and α-(aralkyl)-carboxylic acids. Inclusion of an additional lipophilic moiety affords compounds 14 and 16, equipotent to BRL 48482.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23ae9408701326bba0311013a60899c0
https://doi.org/10.1016/0960-894x(96)00382-4
https://doi.org/10.1016/0960-894x(96)00382-4
Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acids
Autor:
Barrie C. C. Cantello, Carolyn A. Lister, Andrew Faller, Harshad Kantilal Rami, P.J. Coyle, D.G. Smith, Ivan Leo Pinto, L. J. Jefcott, David Haigh, Michael A. Cawthorne, David Kenneth Dean, Stephen A. Smith, Derek R. Buckle, Richard Mark Hindley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2121-2126
The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents can be replaced by a range of α-heteroatom functionalised β-phenylpropanoic acids. α-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3a815b09235557e1b3ee77193befab3
https://doi.org/10.1016/0960-894x(96)00383-6
https://doi.org/10.1016/0960-894x(96)00383-6
Autor:
Stephen A. Smith, Barrie C. C. Cantello, Peter L. Thurlby, Richard Mark Hindley, Michael A. Cawthorne, David Haigh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1181-1184
Modifications based upon a metabolite of ciglitazone afforded BRL 49653, a novel potent insulin sensitizer. A facile synthesis of this compound is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::641f649dc9c565cbc7ffe765036b4dba
https://doi.org/10.1016/s0960-894x(01)80325-5
https://doi.org/10.1016/s0960-894x(01)80325-5
Autor:
Drake S. Eggleston, Barrie C. C. Cantello, David Haigh, Richard Mark Hindley, Catherine M. Heath, Sime John Thomas, Stefan Roland Woroniecki, Keith R. Jennings, R. Curtis Haltiwanger
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :3319-3324
A novel biotransformation system for the reduction of carbon-carbon double bonds in 5-benzylidenethiazolidine-2, 4-diones, to give the corresponding 5-benzylthiazolidine-2, 4-diones, using whole cells of red yeasts is described. These reduced compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9eb392630dd213a99ee9f4e1dd2e980
https://doi.org/10.1039/p19940003319
https://doi.org/10.1039/p19940003319
Autor:
R. C. Haltiwanger, Sime John Thomas, C. M. Heath, Barrie C. C. Cantello, Drake S. Eggleston, Richard Mark Hindley, Stefan Roland Woroniecki, David Haigh, Keith R. Jennings
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57108583d472c9658f1c92b09ecf4db1
https://doi.org/10.1002/chin.199519129
https://doi.org/10.1002/chin.199519129
Autor:
David Kenneth Dean, P.J. Coyle, L. J. Jefcott, Stephen A. Smith, Harshad Kantilal Rami, David Haigh, Michael A. Cawthorne, Barrie C. C. Cantello, Carolyn A. Lister, Andrew Faller, Richard Mark Hindley, Pinto Ivan Leo, Smith David Glynn, Derek R. Buckle
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83be22a4711f29a505a54f9a8f70a0d6
https://doi.org/10.1002/chin.199652298
https://doi.org/10.1002/chin.199652298
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9282907a02f4ef0ad453ab64e44d266c
https://doi.org/10.1002/chin.199739155
https://doi.org/10.1002/chin.199739155
Autor:
Harshad Kantilal Rami, Nicola C. Stevens, Barrie C. C. Cantello, Helen C. Birrell, David Haigh, Richard Mark Hindley, Anantha Ramaswamy
Publikováno v:
ChemInform. 30
The synthesis of a new series of potent 2-oxy-3-arylpropanoic acid antihyperglycaemic agents in both racemic and non-racemic form is described. Resolution of racemic acids 1 is accomplished via amide formation with either ( S )-2-phenylglycinol or (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a1aa60466273c08330d26349c784ff6
https://doi.org/10.1002/chin.199933104
https://doi.org/10.1002/chin.199933104