Zobrazeno 1 - 10
of 73
pro vyhledávání: '"C, Boyles"'
Publikováno v:
Urban Ecosystems. 23:355-362
College/university campuses comprise a distinct type of urban interface, with their generally expansive spatial pattern of alternating permanent structures, parking lots, and green spaces. The campus of the University of West Florida (UWF) in Pensaco
Autor:
Manjinder S. Lall, David C. Boyles, Gerald A. Weisenburger, Barbara J. Sitter, Yong Tao, Andrew Morgan Stewart, Susan C. Lilley, Robert J. Rafka, Sebastian D. Pattavina, Jan Szeliga
Publikováno v:
Organic Process Research & Development. 23:2499-2509
An efficient process to synthesize Monobactam 1 from intermediates 2, 3, and 4 was developed. The process was initially enabled to deliver 500 g of 1 for exploratory toxicity studies and further im...
Autor:
M. Lefevre, Aaron S. Burton, Carina Bennett, J. A. Mapel, Renu Malhotra, Peter Fleming, J. McAdams, N. Mogk, R. L. Ballouz, P. H. Smith, V. Nifo, C. K. Maleszewski, Timothy D. Swindle, E. Dotto, Stephen R. Schwartz, C. May, J. Bayron, D. Patterson, D. Guevel, Ellen S. Howell, Humberto Campins, J. Kissell, E. Brown, J. Wood, E. Muhle, John Robert Brucato, J. Small, B. Miller, Oleksiy Golubov, R. Pennington, K. Harshman, J. Nelson, Catherine Elder, M. McGee, R. Burns, J. Contreras, S. Hull, D. Kubitschek, D. Noss, Andrew J. Liounis, J. Backer, B. May, G. Fitzgibbon, J. Donaldson, D. Worden, Bashar Rizk, R. Witherspoon, Catherine L. Johnson, Erica Jawin, G. Shaw, A. Aqueche, Dolores H. Hill, D. Folta, S. Ferrone, M. Lujan, Giovanni Poggiali, B. G. Williams, S. Selznick, Melissa A. Morris, K. Rios, Sara S. Russell, D. Lambert, J. Hong, Jeffrey B. Plescia, H. Bloomenthal, D. Drinnon, Olivier S. Barnouin, Derek S. Nelson, Amanda E. Toland, Michael C. Moreau, J. A. Seabrook, K. Dill, A. Mirfakhrai, K. Hyde, J. D. P. Deshapriya, Hannah Kaplan, Timothy P. McElrath, Juliette I. Brodbeck, N. Ramos, S. Stewart, James B. Garvin, Sei-ichiro Watanabe, M. Arvizu-Jakubicki, Jason P. Dworkin, Matthew A. Siegler, Collin Lewin, Masatoshi Hirabayashi, L. Bloomquist, S. Gardner, Keiko Nakamura-Messenger, A. H. Nair, M. Schmitzer, P. Haas, Julie Bellerose, Dolan E. Highsmith, L. Koelbel, C. C. Lorentson, J. Zareski, E. Queen, S. R. Chesley, Philip A. Bland, A. Cheuvront, V. E. Hamilton, Ronald G. Mink, N. Mastrodemos, H. C. Connolly, K. Bellamy, M. Killgore, A. Gardner, Y. Takahashi, M. Lambert, R. C. Espiritu, Z. Zeszut, E. T. Morton, Kevin J. Walsh, Timothy D. Glotch, M. Skeen, Brian Kennedy, Matthew R.M. Izawa, G. Neumann, F. Teti, D. Doerres, A. Hasten, F. Ciceri, D. Howell, A. Deguzman, J. Nagy, D. Vaughan, H. Ma, C. Lantz, D. N. Brack, David K. Hammond, Erwan Mazarico, Leilah K. McCarthy, L. Rhoads, Kathleen L. Craft, C. Welch, Jay W. McMahon, C. L. Parish, D. C. Reuter, M. Giuntini, N. Castro, Clive Dickinson, J. Kreiner, K. Kingsbury, S. Dickenshied, Joseph A. Nuth, Alan R. Hildebrand, Erik Asphaug, H. Ido, Eric M. Sahr, A. Harbison, Arlin E. Bartels, T. Forrester, D. Eckart, R. Bandrowski, Michael K. Barker, Robert Gaskell, J. Wendel, S. Freund, Marc Bernacki, Ryan S. Park, A. Taylor, E. B. Bierhaus, S. Millington-Veloza, J. Stromberg, L. B. Breitenfeld, K. Stakkestad, D. Ellis, Timothy J. McCoy, M. Susak, Richard G. Cosentino, C. Manzoni, Hisayoshi Yurimoto, C. Drouet d'Aubigny, A. Bjurstrom, Masako Yoshikawa, S. Francis, J. Peachey, J. Geeraert, K. Marchese, O. Billett, M. Rascon, F. Jaen, B. Diallo, Martin Miner, Kris J. Becker, E. Mazzotta Epifani, Florian Thuillet, A. Knight, James H. Roberts, Pasquale Tricarico, Edward A. Cloutis, T. Fisher, Dale Stanbridge, A. Colpo, Osiris-Rex Team, S. Gonzales, Q. Tran, M. K. Crombie, John Marshall, N. Bojorquez-Murphy, David Vokrouhlický, Allen W. Lunsford, H. Bowles, K. L. Edmundson, R. A. Masterson, Peter G. Antreasian, N. Gorius, Benjamin Rozitis, D. Pino Muñoz, S. Carlson-Kelly, C. Thayer, J. Elsila Cook, B. C. Clark, N. Piacentine, José C. Aponte, M. Al Asad, M. A. Barucci, D. Blum, P. Falkenstern, Neil Bowles, Matthew Chojnacki, J. M. Leonard, J. Daly, K. Yetter, M. R. Fisher, Jeffrey N. Grossman, A. Boggs, N. Jayakody, Cristina A. Thomas, C.M. Ernst, Namrah Habib, J. N. Kidd, R. J. Steele, Andrew B. Calloway, Andrew Ryan, Kimberly T. Tait, Paul O. Hayne, J. Y. Li, K. L. Berry, William V. Boynton, Yanga R. Fernandez, D. A. Lorenz, M. Wasser, Daniel J. Scheeres, K. Fortney, A. Scroggins, B. Allen, B. Sutter, T. Ferro, Jonathan Joseph, Derek C. Richardson, D. Hoak, Brian Carcich, W. Chang, P. Wren, C. Boyles, Kaj E. Williams, B. Marty, J. Liang, J. Hoffman, A. Harch, Daniel R. Wibben, Jamie Molaro, S. Rieger, R. Enos, C. W. Hergenrother, Stephen R. Sutton, J. Grindlay, E. J. Lessac-Chenen, E. Huettner, C. Norman, P. Sherman, L. Swanson, M. Coltrin, S. Van wal, B. Buck, A. Fisher, Kevin Righter, Brian Rush, David D. Rowlands, Lauren McGraw, A. Levine, K. Drozd, D. Gaudreau, A. Nguyen, S. Sides, M. Chodas, R. Dubisher, B. Ashman, Michael Caplinger, Amy Simon, W. Moore, S. S. Balram-Knutson, R. Carpenter, S. Fornasier, Shogo Tachibana, Russell Turner, Ian A. Franchi, Trevor Ireland, Chloe B. Beddingfield, D. F. Everett, M. Corvin, Lindsay P. Keller, Tammy L. Becker, S. Carter, J. L. Rizos Garcia, Mark E. Perry, E. Keates, Michael C. Nolan, P. Vasudeva, C. Fellows, K. Herzog, Mark A. Jenkins, J. R. Weirich, J. Swenson, D. R. Golish, Davide Farnocchia, Lydia C. Philpott, Rebecca R. Ghent, Hannah C.M. Susorney, S. W. Squyres, Pedro Hasselmann, J. Hill, Thomas J. Zega, B. Key, Marco Delbo, A. S. French, P. Sánchez, A. Hilbert, J. Y. Pelgrift, R. P. Binzel, L. McNamara, Vishnu Reddy, Michael Daly, Scott Messenger, Daniella DellaGiustina, Maurizio Pajola, Charles Brunet, Joshua L. Bandfield, J. Padilla, A. Janakus, M. Moreau, R. Garcia, R. A. Chicoine, P. Michel, P. Kaotira, K. S. Johnson, J. Forelli, G. Miller, K. Martin, I. Galinsky, S. Desjardins, Naru Hirata, Christine Hartzell, M. L. Jones, S. Hooven, D. Velez, R. Munoz, Carolyn M. Ernst, C. Emr, N. Martinez-Vlasoff, S. Bendall, R. Zellar, E. Church, Theodore Kareta, T. Warren, P. Wolff, V. Morrison, C. Bryan, S. Bhaskaran, N. Jones, D. Hauf, Jeremy Bauman, R. T. Daly, R. Olds, M. M. Westermann, D. K. Hamara, E. Audi, G. Johnston, Eric Palmer, Courtney Mario, Daniel P. Glavin, T. Haltigin, J. Cutts, Javier Licandro, Xiao-Duan Zou, H. L. Roper, Gregory A. Neumann, William M. Owen, S. Sugita, Y. H. Tang, Kevin Burke, H. L. Enos, D. Gallagher, William F. Bottke, K. Getzandanner, Philip R. Christensen, C. W. V. Wolner, K. Fleshman, D. Poland, J. P. Emery, M.M. Riehl, D. Fennell, D. Sallitt, A. D. Rogers, M. Fitzgibbon, John H. Jones, S. Mullen, S. Salazar, S. Oliver, A. T. Polit, J. Cerna, A. Praet, Mark E. Holdridge, E. M. Ibrahim, Coralie D. Adam, J. de León, Christopher J. Miller, M. Ryle, J. Lyzhoft, M. Loveridge, C. Hoekenga, Brent J. Bos, S. Anwar, K. Chaffin, Devin L. Schrader, B. Lovelace, Romy D. Hanna, C. D. Adam, G. L. Mehall, K. L. Donaldson Hanna, F. Merlin, B. Wright, Guy Libourel, L. F. Lim, N. Shultz, Dante S. Lauretta, K. Hanley, Beth E. Clark, L. Le Corre, K. Thomas-Keprta, Moses Milazzo, W. Hagee, B. Page, M. Fisher, E. McDonough, D. Trang, S. Clemett, A. Rubi, A. Ingegneri, Scott A. Sandford, D. Dean, J. Freemantle, Michael D. Smith, Christopher W. Haberle, L. Nguyen, M. Fulchignoni
Publikováno v:
Nature Geoscience
Nature Geoscience, Nature Publishing Group, 2020, 13 (11), pp.764-764. ⟨10.1038/s41561-020-0643-9⟩
Nature Geoscience, Nature Publishing Group, 2020, 13 (11), pp.764-764. ⟨10.1038/S41561-020-0643-9⟩
Nature Geoscience, Nature Publishing Group, 2020, 13 (11), pp.764-764. ⟨10.1038/s41561-020-0643-9⟩
Nature Geoscience, Nature Publishing Group, 2020, 13 (11), pp.764-764. ⟨10.1038/S41561-020-0643-9⟩
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae14f089ac50e60c709ad1239d1c7fe1
https://hal.archives-ouvertes.fr/hal-03434288
https://hal.archives-ouvertes.fr/hal-03434288
Autor:
David C. Boyles, Jianmin Sun, Joel T. Arcari, Matthew Frank Brown, Yong Tao, Susan C. Lilley, Jeremy T. Starr, Manjinder S. Lall, Andrew Morgan Stewart, Mark J. Mitton-Fry, David B. Damon
Publikováno v:
Organic Process Research & Development. 22:212-218
Process development and multikilogram synthesis of the monocyclic β-lactam core 17 for a novel pyridone-conjugated monobactam antibiotic is described. Starting with commercially available 2-(2,2-diethoxyethyl)isoindoline-1,3-dione, the five-step syn
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Autor:
Jotham Wadsworth Coe, Phillip J. Fiore, Ian Edmonds, Jeffrey B. Sperry, Wiglesworth Kristin, Eugene Lvovich Piatnitski Chekler, Jonathan Langille, David C. Boyles, Roberta Louise Dorow, David B. Damon
Publikováno v:
Organic Process Research & Development. 18:1752-1758
This work describes the optimization and scale-up of a Buchwald–Hartwig amination reaction for the preparation of a pharmaceutical intermediate. This C–N bond formation is challenged by the use of a chiral primary amine, which both adds cost and
Autor:
Ian B. Moses, Rick Rodriguez, Peter Robert Rose, Corey L. Stanchina, Cuthbertson Timothy J, Asayuki Kamatani, Pieter D. de Koning, Alison Sandoval, Kyle Kissick, Robert Moore, Leera Rahman, Douglas McAndrew, Armando Urbina, David C. Boyles
Publikováno v:
Organic Process Research & Development. 15:1018-1026
A robust six-step process for the synthesis of crizotinib, a novel c-Met/ALK inhibitor currently in phase III clinical trials, has been developed and used to deliver over 100 kg of API. The process includes a Mitsunobu reaction, a chemoselective redu
Autor:
David C. Boyles, Stephanie Schuyler, Edward J. Hessler, Jeffrey A. Pfefferkorn, Daniel Merritt Bowles, Chulho Choi
Publikováno v:
Organic Process Research & Development. 15:148-157
Early process development work toward a promising pyrazole-based HMG-CoA reductase inhibitor is described. PF-03052334-02 (1) was prepared in 14 synthetic steps with a 21% overall yield, highlighted by a modified three-step hydroxypyrazole formation
Autor:
Anne Akin, Jacob Bradley Schwarz, Johnson Paul D, Peter G. Blazecka, Osuma Augustine Tobi, Derek Vrieze, Mark S. Plummer, Yun Huang, Ji Zhang, Michael Lovdahl, Norman L. Colbry, Brian Samas, Joseph Richard Bozelak, Timothy T. Curran, Andrew John Thorpe, Derek A. Pflum, Annise Paige Goodman, David C. Boyles, Garrett Hoge, Suzanne Ross Kesten
Publikováno v:
Tetrahedron Letters. 50:1167-1170
A chiral β-amino acid containing three contiguous chiral centers was synthesized efficiently in 11 steps, employing enantio-enriched β-ketoester as a key intermediate, via stereoselective catalytic hydrogenation of the corresponding enamide. Stereo
Autor:
Daniel Merritt Bowles, David C. Schineman, Markus Tamm, Kurtis G. Ritsema, Jonathan Mark Miller, William Keun Chan Park, David C. Boyles, Scott D. Larsen, Richard H. Hutchings, Timothy T. Curran, Gary Louis Bolton
Publikováno v:
Organic Process Research & Development. 12:1183-1187
Development work toward an enabling synthesis of preparative scale batches of an imidazole-based HMG-CoA reductase inhibitor is described. The desired target was synthesized in 16% yield over 7 steps, highlighted by an imidazole-forming condensation