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of 1 406
pro vyhledávání: '"C, Bain"'
Disruption often drives innovation, and 2020 was certainly an extraordinary year for all health professionals. Not only did it stretch individual providers and healthcare systems to their limits, it highlighted the urgent and rapid need to mobilize d
Autor:
Peter Rossing, Stephen C. Bain, Heidrun Bosch-Traberg, Ekaterina Sokareva, Hiddo J. L. Heerspink, Søren Rasmussen, Linda G. Mellbin
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-11 (2023)
Abstract Background Semaglutide is a glucose-lowering treatment for type 2 diabetes (T2D) with demonstrated cardiovascular benefits; semaglutide may also have kidney-protective effects. This post hoc analysis investigated the association between majo
Externí odkaz:
https://doaj.org/article/c520c57dfa9343559d55cf333ed71c54
Autor:
Adie Viljoen, Stephen C. Bain
Publikováno v:
Endocrinology and Metabolism, Vol 38, Iss 1, Pp 25-33 (2023)
The therapeutic benefits of the incretin hormone, glucagon-like peptide 1 (GLP1), for people with type 2 diabetes and/or obesity, are now firmly established. The evidence-base arising from head-to-head comparative effectiveness studies in people with
Externí odkaz:
https://doaj.org/article/f3f7f06eb156473d8f2e691e8b2dd059
Autor:
Bendix Carstensen, Stephen C Bain, Hanan Amadid, Alice Clark, Liselotte Hyveled, Stephanie Seremetis, Frederik Flindt Kreiner
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 11, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/aa780592781249ba85931358967af496
Autor:
Pamela B. Wright, Elizabeth McDonald, Alberto Bravo-Blas, Hannah M. Baer, Anna Heawood, Calum C. Bain, Allan M. Mowat, Slater L. Clay, Elaine V. Robertson, Fraser Morton, Jagtar Singh Nijjar, Umer Z. Ijaz, Simon W. F. Milling, Daniel R. Gaya
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract To understand the contribution of mononuclear phagocytes (MNP), which include monocyte-derived intestinal macrophages, to the pathogenesis of inflammatory bowel disease (IBD), it is necessary to identify functionally-different MNP population
Externí odkaz:
https://doaj.org/article/4a39c7bad69f4132860514691588ed0f
Autor:
M. S. Magalhaes, P. Smith, J. R. Portman, L. H. Jackson-Jones, C. C. Bain, P. Ramachandran, Z. Michalidou, R. H. Stimson, M. R. Dweck, L. Denby, N. C. Henderson, S. J. Jenkins, C. Bénézech
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Diverse macrophage subsets are found in adipose tissue where they regulate its physiology. Here, the authors used single-cell RNA sequencing to analyse the effect of post-prandial lipids on adipose tissue macrophages and identify Tim4 as a regulator
Externí odkaz:
https://doaj.org/article/39a4cc25e8ac438eaf00455de7457431
Autor:
Olivia McCarthy, Signe Schmidt, Merete Bechmann Christensen, Stephen C. Bain, Kirsten Nørgaard, Richard Bracken
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Although important for digestion and metabolism in repose, the healthy endocrine pancreas also plays a key role in facilitating energy transduction around physical exercise. During exercise, decrements in pancreatic β-cell mediated insulin release o
Externí odkaz:
https://doaj.org/article/c766091d5de44e96b641b5bece4c5fc0
Autor:
P. A. Louwe, L. Badiola Gomez, H. Webster, G. Perona-Wright, C. C. Bain, S. J. Forbes, S. J. Jenkins
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The peritoneal cavity is a complicated myeloid niche containing a mixed population of resident macrophages and infiltrating cells that are responsive to inflammatory cues. Here the authors trace the fate of these infiltrating macrophages, their conve
Externí odkaz:
https://doaj.org/article/33ac849202d4420a84888f070446b56d
Autor:
Mansoor Husain, Stephen C. Bain, Anders Gaarsdal Holst, Thomas Mark, Søren Rasmussen, Ildiko Lingvay
Publikováno v:
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-11 (2020)
Abstract Background Semaglutide is a glucagon-like peptide-1 (GLP-1) analog treatment for type 2 diabetes (T2D) available in subcutaneous (s.c.) and oral formulations. Two cardiovascular (CV) outcomes trials showed that in subjects with T2D at high r
Externí odkaz:
https://doaj.org/article/1fa943b06d484e5e81540ed1fcf28c49
Autor:
M. Bush, T. Allen, C. Bain, I. Boutle, J. Edwards, A. Finnenkoetter, C. Franklin, K. Hanley, H. Lean, A. Lock, J. Manners, M. Mittermaier, C. Morcrette, R. North, J. Petch, C. Short, S. Vosper, D. Walters, S. Webster, M. Weeks, J. Wilkinson, N. Wood, M. Zerroukat
Publikováno v:
Geoscientific Model Development, Vol 13, Pp 1999-2029 (2020)
In this paper we define the first Regional Atmosphere and Land (RAL) science configuration for kilometre-scale modelling using the Unified Model (UM) as the basis for the atmosphere and the Joint UK Land Environment Simulator (JULES) for the land. RA
Externí odkaz:
https://doaj.org/article/8ceb8d15a7de4937885d787ba8bf1e36