Zobrazeno 1 - 10
of 625
pro vyhledávání: '"C, Auer"'
Autor:
David J. Stewart, John-Peter Bradford, Sandeep Sehdev, Tim Ramsay, Vishal Navani, Nigel S. B. Rawson, Di Maria Jiang, Joanna Gotfrit, Paul Wheatley-Price, Geoffrey Liu, Alan Kaplan, Silvana Spadafora, Shaun G. Goodman, Rebecca A. C. Auer, Gerald Batist
Publikováno v:
Current Oncology, Vol 31, Iss 5, Pp 2453-2480 (2024)
Countries face challenges in paying for new drugs. High prices are driven in part by exploding drug development costs, which, in turn, are driven by essential but excessive regulation. Burdensome regulation also delays drug development, and this can
Externí odkaz:
https://doaj.org/article/e2a0bda42f934ee6ba8bb491b5743aa9
Autor:
Natalie G Coburn, Guillaume Martel, Jad Abou Khalil, Fady Balaa, Kimberly A Bertens, Julie Hallet, Rebecca C Auer, Paul Jack Karanicolas, Calvin Law, Ramy Behman, Lev Bubis, Grace Xu
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction Surgical stress results in immune dysfunction, predisposing patients to infections in the postoperative period and potentially increasing the risk of cancer recurrence. Perioperative immunonutrition with arginine-enhanced diets has been
Externí odkaz:
https://doaj.org/article/bff43fb84ca04a6da6ef9887dc5d9358
Autor:
P. Rauch, H. Stefanits, M. Aichholzer, C. Serra, D. Vorhauer, H. Wagner, P. Böhm, S. Hartl, I. Manakov, M. Sonnberger, E. Buckwar, F. Ruiz-Navarro, K. Heil, M. Glöckel, J. Oberndorfer, S. Spiegl-Kreinecker, K. Aufschnaiter-Hiessböck, S. Weis, A. Leibetseder, W. Thomae, T. Hauser, C. Auer, S. Katletz, A. Gruber, M. Gmeiner
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Determining the optimal course of treatment for low grade glioma (LGG) patients is challenging and frequently reliant on subjective judgment and limited scientific evidence. Our objective was to develop a comprehensive deep learning assisted
Externí odkaz:
https://doaj.org/article/73ba3a08a3c0440faa53a69c692c84bb
Autor:
Donald J. Bastin, Joshua Montroy, Michael A. Kennedy, Andre B. Martel, Risa Shorr, Maryam Ghiasi, Dominique M. Boucher, Boaz Wong, Louise Gresham, Jean-Simon Diallo, Dean A. Fergusson, Manoj M. Lalu, Natasha Kekre, Rebecca C. Auer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract We conducted a systematic review and meta-analysis of randomized control trials to formally assess the safety and efficacy of autologous whole cell vaccines as immunotherapies for solid tumors. Our primary safety outcome was number, and grad
Externí odkaz:
https://doaj.org/article/ddd371329bd54c08b78dd40a6df911c2
Autor:
Marie-Eve Wedge, Victoria A. Jennings, Mathieu J. F. Crupi, Joanna Poutou, Taylor Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J. Laight, Meaghan Boileau, Zaid Taha, Nouf Alluqmani, Hayley E. McKay, Larissa Pikor, Sarwat Tahsin Khan, Taha Azad, Reza Rezaei, Bradley Austin, Xiaohong He, David Mansfield, Elaine Rose, Emily E. F. Brown, Natalie Crawford, Almohanad Alkayyal, Abera Surendran, Ragunath Singaravelu, Dominic G. Roy, Gemma Migneco, Benjamin McSweeney, Mary Lynn Cottee, Egon J. Jacobus, Brian A. Keller, Takafumi N. Yamaguchi, Paul C. Boutros, Michele Geoffrion, Katey J. Rayner, Avijit Chatterjee, Rebecca C. Auer, Jean-Simon Diallo, Derrick Gibbings, Benjamin R. tenOever, Alan Melcher, John C. Bell, Carolina S. Ilkow
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
RNA-based viruses can be engineered to express artificial microRNAs (amiRNAs). Here, the authors identify a candidate amiRNA that confers a replicative advantage to oncolytic viruses, enhancing their anticancer potency, and show that intercellular tr
Externí odkaz:
https://doaj.org/article/4c63ee51ae0d403a99532dab542cb349
Publikováno v:
BDJ Open, Vol 8, Iss 1, Pp 1-6 (2022)
Abstract Objective To evaluate temporomandibular disorder (TMD) treatment with a prefabricated, hydrostatic oral splint (HOS) based on self-reported patient’s symptoms using a standardized questionnaire. Methods Two hundred fifty-eight questionnair
Externí odkaz:
https://doaj.org/article/f973ee273dda45ce8646ee019a25d2bf
Autor:
John Abou-Hamad, Jonathan J. Hodgins, Christiano T. de Souza, Brennan Garland, Cédrik Labrèche, Marie Marotel, Cameron Gibson, Samuel Delisle, Julia Pascoal, Rebecca C. Auer, Michele Ardolino, Luc A. Sabourin
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105524- (2022)
Summary: SOX10 is a key regulator of melanoma progression and promotes a melanocytic/differentiated state. Here we identified melanoma cell lines lacking SOX10 expression which retain their in vivo growth capabilities. More importantly, we find that
Externí odkaz:
https://doaj.org/article/627ac5f7b4ef457cb4fd187908d34dd8
Autor:
Nouf Alluqmani, Anna Jirovec, Zaid Taha, Oliver Varette, Andrew Chen, Daniel Serrano, Glib Maznyi, Sarwat Khan, Nicole E. Forbes, Rozanne Arulanandam, Rebecca C. Auer, Jean-Simon Diallo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Oncolytic viruses (OVs) are promising anticancer treatments that specifically replicate in and kill cancer cells and have profound immunostimulatory effects. We previously reported the potential of vanadium-based compounds such as vanadyl sulfate (VS
Externí odkaz:
https://doaj.org/article/31b68295a0e340bdba30274553e1eac0
Autor:
D. G. Roy, K. Geoffroy, M. Marguerie, S. T. Khan, N. T. Martin, J. Kmiecik, D. Bobbala, A. S. Aitken, C. T. de Souza, K. B. Stephenson, B. D. Lichty, R. C. Auer, D. F. Stojdl, J. C. Bell, M.-C. Bourgeois-Daigneault
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Viruses expressing tumour antigens can prime and boost anti-tumour immunity but the efficiency of this approach depends on the capacity of the virus to infect the host. Here, the authors show that vaccination with oncolytic viruses co-administered wi
Externí odkaz:
https://doaj.org/article/0087d0d0e932497c868d4c3d99452a6d
Autor:
Marisa Market, Gayashan Tennakoon, Marlena Scaffidi, David P. Cook, Leonard Angka, Juliana Ng, Christiano Tanese de Souza, Michael A. Kennedy, Barbara C. Vanderhyden, Rebecca C. Auer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14608 (2022)
Natural Killer (NK) cell cytotoxicity and interferon-gamma (IFNγ) production are profoundly suppressed postoperatively. This dysfunction is associated with increased morbidity and cancer recurrence. NK activity depends on the integration of activati
Externí odkaz:
https://doaj.org/article/2a99e8c2bce74c7c9f8de42746bba024