Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Byunghee Koh"'
Autor:
Taehyeung Kim, Marta Martínez-Bonet, Qiang Wang, Nicolaj Hackert, Jeffrey A. Sparks, Yuriy Baglaenko, Byunghee Koh, Roxane Darbousset, Raquel Laza-Briviesca, Xiaoting Chen, Vitor R. C. Aguiar, Darren J. Chiu, Harm-Jan Westra, Maria Gutierrez-Arcelus, Matthew T. Weirauch, Soumya Raychaudhuri, Deepak A. Rao, Peter A. Nigrovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Fine-mapping and functional studies implicate rs117701653, a non-coding single nucleotide polymorphism in the CD28/CTLA4/ICOS locus, as a risk variant for rheumatoid arthritis and type 1 diabetes. Here, using DNA pulldown, mass spectrometry,
Externí odkaz:
https://doaj.org/article/89591f74d78449f789de95d34d7df2b8
Autor:
Yongyao Fu, Jocelyn Wang, Gayathri Panangipalli, Benjamin J. Ulrich, Byunghee Koh, Chengxian Xu, Rakshin Kharwadkar, Xiaona Chu, Yue Wang, Hongyu Gao, Wenting Wu, Jie Sun, Robert S. Tepper, Baohua Zhou, Sarath Chandra Janga, Kai Yang, Mark H. Kaplan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subset
Externí odkaz:
https://doaj.org/article/f65e400bd7f5452ca8fba9f15ba2dcc0
Autor:
Byunghee Koh, Amina Abdul Qayum, Rajneesh Srivastava, Yongyao Fu, Benjamin J. Ulrich, Sarath Chandra Janga, Mark H. Kaplan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Interleukin-9 (IL-9) is important for allergy, autoimmunity and tumor immunity, but how its expression is regulated is unclear. Here the authors show the essential function of an enhancer, CNS-25 in mouse and CNS-18 in human, for IL-9 expression, wit
Externí odkaz:
https://doaj.org/article/c61519e680244108827ba600002853d5
Autor:
Jonathan P Riley, Aishwarya Kulkarni, Purvi Mehrotra, Byunghee Koh, Narayanan B Perumal, Mark H Kaplan, Shreevrat Goenka
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83127 (2013)
PARP-14, a member of the poly ADP-ribose polymerase super family, promotes T helper cell 2 (Th2) differentiation by regulating interleukin-4 (IL-4) and STAT6-dependent transcription. Yet, whether PARP-14 globally impacts gene regulation has not been
Externí odkaz:
https://doaj.org/article/8094d98b75e34f98b792cf153941edf5
Autor:
Rakshin Kharwadkar, Benjamin J. Ulrich, Michelle Chu, Byunghee Koh, Matthew M. Hufford, Yongyao Fu, Graeme M. Birdsey, Bo T. Porse, Anna M. Randi, Mark H. Kaplan
Publikováno v:
The Journal of Immunology. 210:537-546
CD4+ TH cells develop into subsets that are specialized in the secretion of particular cytokines to mediate restricted types of inflammation and immune responses. Among the subsets that promote development of allergic inflammatory responses, IL-9–p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b7d6c84c4170873d620b8d400d2304
https://doi.org/10.4049/jimmunol.2200113
https://doi.org/10.4049/jimmunol.2200113
Autor:
Benjamin J. Ulrich, Rakshin Kharwadkar, Michelle Chu, Abigail Pajulas, Charanya Muralidharan, Byunghee Koh, Yongyao Fu, Hongyu Gao, Tristan A. Hayes, Hong-Ming Zhou, Nick P. Goplen, Andrew S. Nelson, Yunlong Liu, Amelia K. Linnemann, Matthew J. Turner, Paula Licona-Limón, Richard A. Flavell, Jie Sun, Mark H. Kaplan
Publikováno v:
Science Immunology. 7
Asthma is a chronic inflammatory lung disease with intermittent flares predominately mediated through memory T cells. Yet, the identity of long-term memory cells that mediate allergic recall responses is not well defined. In this report, using a mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::222bfca7aa6535e7434174194fde4df6
https://doi.org/10.1126/sciimmunol.abg9296
https://doi.org/10.1126/sciimmunol.abg9296
Autor:
Paula Licona-Limón, Byunghee Koh, Benjamin J. Ulrich, Amina Abdul Qayum, Richard A. Flavell, Rakshin Kharwadkar, Mark H. Kaplan
Publikováno v:
ImmunoHorizons. 4:282-291
Generation of allelic gene reporter mice has provided a powerful tool to study gene function in vivo. In conjunction with imaging technologies, reporter mouse models facilitate studies of cell lineage tracing, live cell imaging, and gene expression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bd0eceaf06d5ff3ef86e1c8c7296c58
https://doi.org/10.4049/immunohorizons.1900082
https://doi.org/10.4049/immunohorizons.1900082
Autor:
Yongyao Fu, Jocelyn Wang, Baohua Zhou, Abigail Pajulas, Hongyu Gao, Baskar Ramdas, Byunghee Koh, Benjamin J. Ulrich, Shuangshuang Yang, Reuben Kapur, Jean-Christophe Renauld, Sophie Paczesny, Yunlong Liu, Robert M. Tighe, Paula Licona-Limón, Richard A. Flavell, Shogo Takatsuka, Daisuke Kitamura, Robert S. Tepper, Jie Sun, Mark H. Kaplan
Publikováno v:
Science Immunology. 7
Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9–responsive cell repertoire is still not well defined. Here, we found that IL-9 mediates proallergic activities in the lungs by targeting lung macrophages. IL-9 inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b03c2816ad87ac4924df25b4e8e8d1a
https://doi.org/10.1126/sciimmunol.abi9768
https://doi.org/10.1126/sciimmunol.abi9768
Autor:
Byunghee Koh
Publikováno v:
Nubebe Mibyeong Research Institute. 2:33-35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1dba14ef34dcefba049710bfcfe772e
https://doi.org/10.37928/kjsm.2021.2.1.33
https://doi.org/10.37928/kjsm.2021.2.1.33
Autor:
Rakshin Kharwadkar, Byunghee Koh, Benjamin J. Ulrich, Makoto Kuwahara, Mark H. Kaplan, Masakatsu Yamashita, Yongyao Fu
Publikováno v:
J Immunol
The basic leucine zipper (bZIP) transcription factor BATF is expressed in multiple Th subsets and cooperates with other factors to regulate gene transcription. BATF activates lineage-specific cytokines in Th subsets, activating IL-9 in Th9 cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdbbba95c627dd0eebd5c7a070f50a0
https://doi.org/10.4049/jimmunol.1900128
https://doi.org/10.4049/jimmunol.1900128