Výsledky vyhledávání - "Byung-Ha Chang"

Darapladib Binds to Lipoprotein-Associated Phospholipase A2 with Meaningful Interactions

Autor: Jee-Young Lee, Kyoung Tai No, Seong Soo A. An, Jae Min Shin, Sang Jun Yea, Mi Young Song, Chul Hoon Kim, Kyoung Rok Do, Byung-Ha Chang

Publikováno v: Bulletin of the Korean Chemical Society. 35:250-252

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a crucial enzyme in atherosclerosis as a potential drug target. The most remarkable Lp-PLA2 inhibitory drug is Darapladib. We determined the binding pose of Darapladib to Lp-PLA2 through docking st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac0ba9374af9fdd6d00e7b7ac83b425d
https://doi.org/10.5012/bkcs.2014.35.1.250

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Investigation of the Protonated State of HIV-1 Protease Active Site

Autor: Chul Kyu Han, Ky Youb Nam, Soon Gil Ahn, Byung Ha Chang, Kyoung Tai No

Publikováno v: Bulletin of the Korean Chemical Society. 24:817-823

We have performed ab initio calculation on the active site of HIV-1 protease. The FEP method was used to determine the binding free energy of four different of protonated states of HIV-1 protease with inhibitor. The structure of the active site and h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e084ccd08a5e28721d976ff734d47867
https://doi.org/10.5012/bkcs.2003.24.6.817

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Synthesis of Novel Quinolinecarboxamide Derivatives with Estrogenic Activity

Autor: Si-Ho Park, Jeong-Hyeok Yoon, Byung-Ha Chang, Chong-Ho Park, Hong-Sig Sin, Soo-Jong Um

Publikováno v: Bulletin of the Korean Chemical Society. 24:677-680

Fl., Byolyang-dong, Kwacheon-shi, Kyonggi-do 427-040, KoreaReceived January 29, 2003Key Words : Estrogen, Quinolinecarboxamide derivatives, Virtual screening, Functional group, Estrogenreceptor (ER) Even though estrogens have a well-established role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8511636f771de5cdf98b461af2f1fe7
https://doi.org/10.5012/bkcs.2003.24.5.677

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3',4'-Dihydroxyl Groups in Luteolin are Important for Its Inhibitory Activities against ADAMTS-4

Autor: Jiwon Choi, Yangmee Kim, Jin-Kyoung Kim, Ki-Woong Jeong, Byung-Ha Chang, Jee-Young Lee

Publikováno v: Bulletin of the Korean Chemical Society. 33:2907-2909

A disintegrin and metalloprotease with thrombospondin domains (ADAMTS) are a member of peptidase and involved in processing of von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan. Among 19 subfamilies of human ADAMT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d86ab59286f908a4284c0ced2283d13c
https://doi.org/10.5012/bkcs.2012.33.9.2907

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Description of the potential energy surface of the water dimer with an artificial neural network

Autor: Kyoung Tai No, Su Yeon Kim, Mu Shik Jhon, Byung Ha Chang, Harold A. Scheraga

Publikováno v: Chemical Physics Letters. 271:152-156

A potential energy function for the water dimer has been developed with an artificial neural network (back propagation of error algorithm). The potential energy surface was obtained with 6s3p3d/3s3p MP2 ab initio MO calculations. The trained neural n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e00ab78c945bc3ce2299c613f5189b0
https://doi.org/10.1016/s0009-2614(97)00448-x

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Identification of novel rab27a/melanophilin blockers by pharmacophore-based virtual screening

Autor: Jae Sung Hwang, Jong Il Park, Kyoung Tai No, Byung Ha Chang, Jong Young Joung, Ky Youb Nam, Jee-Young Lee, Ha Yeon Lee

Publikováno v: Applied biochemistry and biotechnology. 172(4)

Melanocytes are unique cells that produce specific melanin-containing intracellular organelles called melanosomes. Melanosomes are transported from the perinuclear area of melanocytes toward the plasma membrane as they become more melanized in order

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57dda53f6d01d7c62f4f8c97bcd11ac3
https://pubmed.ncbi.nlm.nih.gov/24293275

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IDMap: facilitating the detection of potential leads with therapeutic targets

Autor: Min-Seok Kwon, Soyang Ha, Jeong Hyeok Yoon, Cheol Kyu Han, Young-Ju Seo, Byung-Ha Chang

Publikováno v: Bioinformatics (Oxford, England). 24(11)

Summary: Pharmaceutical industry has been striving to reduce the costs of drug development and increase productivity. Among the many different attempts, drug repositioning (retargeting existing drugs) comes into the spotlight because of its financial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00a806975c5cc188d2876f53f2b46f9
https://pubmed.ncbi.nlm.nih.gov/18417489

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Conformational Study of N-terminal Prion Peptides by Molecular Dynamics Simulations

Autor: Kyoung Tai No, Ky Youb Nam, Byung Ha Chang

Publikováno v: Bulletin of the Korean Chemical Society. 32:3553-3554

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ce985d1fb5357842c8bfbc54ed6ef78
https://doi.org/10.5012/bkcs.2011.32.10.3553

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