Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Byung-Eun Kim"'
Autor:
Kimberly A. Jett, Zakery N. Baker, Amzad Hossain, Aren Boulet, Paul A. Cobine, Sagnika Ghosh, Philip Ng, Orhan Yilmaz, Kris Barreto, John DeCoteau, Karen Mochoruk, George N. Ioannou, Christopher Savard, Sai Yuan, Osama H.M.H. Abdalla, Christopher Lowden, Byung-Eun Kim, Hai-Ying Mary Cheng, Brendan J. Battersby, Vishal M. Gohil, Scot C. Leary
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 1 (2023)
Signaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology of many metabolic disorders. Here, we identified a copper-linked signaling circuit activate
Externí odkaz:
https://doaj.org/article/018c1e9c28eb4a92a02a5abcb7afd106
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Copper (Cu) is an essential trace element for key biochemical reactions. Dietary or genetic copper deficiencies are associated with anemia, cardiomyopathy, and neurodegeneration. The essential requirement for copper in humans is illustrated by Menkes
Externí odkaz:
https://doaj.org/article/a8bdb3480b6643b3b8f925ea589e0af8
Autor:
Hannah Faith Greene, Byung-Eun Kim, Michael J. Petris, Mohammad Zulkifli, Liam M. Guthrie, James C. Sacchettini, Elyssa Nunez, Thomas Snavely, Arjun Acharya, Andres Silva, Vishal M. Gohil, Brogan Lynch, Vinit Shanbhag, Sai Yuan, Franklin R. Lopez, Shivatheja Soma, Courtney De Ville
Publikováno v:
Science
Elesclomol rescues Menkes disease mice Menkes disease results from loss-of-function mutations in the P-type copper-transporting adenosine triphosphatase ATP7A. Children diagnosed with Menkes present with connective tissue abnormalities and neurodegen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8e07eb8a2db245d605c596bc6aa201
https://doi.org/10.1126/science.aaz8899
https://doi.org/10.1126/science.aaz8899
Autor:
Sung Joo Bae, Byung Eun Kim
Publikováno v:
Journal of Korea Technology Innovation Society. 22:307-339
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f8248e562a3bc628387cec82482b5a3
https://doi.org/10.35978/jktis.2019.06.22.3.307
https://doi.org/10.35978/jktis.2019.06.22.3.307
Autor:
Shivatheja Soma, Jennifer J. Rahn, Haarin Chun, Alison C. Vicary, Aren Boulet, Jonathan D. Gitlin, Andrew J. Latimer, Byung-Eun Kim, Scot C. Leary, Vishal M. Gohil, Shrishiv A. Timbalia, Sherine S.L. Chan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Inherited pathogenic mutations in genes required for copper delivery to cytochrome c oxidase (CcO) perturb mitochondrial energy metabolism and result in fatal mitochondrial disease. A prior attempt to treat human patients with these muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c766929edee9e6b281ec386c9b2475
http://europepmc.org/articles/PMC6094114
http://europepmc.org/articles/PMC6094114
Autor:
Aren Boulet, Byung-Eun Kim, Zakery N. Baker, Glen F. Tibbits, Kimberly A. Jett, Amr M. El Zawily, Ling Lee, Paul A. Cobine, Scot C. Leary, Amzad Hossain, Michael J. Petris
Publikováno v:
Human Molecular Genetics
SCO1 is a ubiquitously expressed, mitochondrial protein with essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper homeostasis. SCO1 patients present with severe forms of early onset disease, and ultimately succumb from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7903af6f9b26dea3d83c4678d69449
https://doi.org/10.1093/hmg/ddx344
https://doi.org/10.1093/hmg/ddx344
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
Copper (Cu) is an essential cofactor for various enzymatic activities including mitochondrial electron transport, iron mobilization, and peptide hormone maturation. Consequently, Cu dysregulation is associated with fatal neonatal disease, liver and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17553898b0b13c53801266dab47eb95a
http://link.springer.com/article/10.1038/s41598-017-11961-z
http://link.springer.com/article/10.1038/s41598-017-11961-z
Publikováno v:
Journal of Biological Chemistry. 292:1-14
Copper plays key catalytic and regulatory roles in biochemical processes essential for normal growth, development, and health. Defects in copper metabolism cause Menkes and Wilson's disease, myeloneuropathy, and cardiovascular disease and are associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892df60dbab51542f304818103c3ffec
https://doi.org/10.1074/jbc.m116.760876
https://doi.org/10.1074/jbc.m116.760876
Autor:
Siwon Kim, Hyeon Jeong Kim, Byung Eun Kim, Elijah Hwejin Lee, Jong Seok Yoo, Yong Sup Lee, Hyeon Ji Kim, Ki Duk Park, Jiwon Choi, Jong Hyun Park
Publikováno v:
European Journal of Medicinal Chemistry. 212:113103
The Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a pivotal role in the cellular defense system against oxidative stress by inducing antioxidant and anti-inflammatory effects. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d599dcf592a1ffe17c51d324c81b35
https://doi.org/10.1016/j.ejmech.2020.113103
https://doi.org/10.1016/j.ejmech.2020.113103
Autor:
Dennis R. Winge, Michael J. Petris, Chul-Jin Lee, Tamara Korolnek, Haarin Chun, Byung-Eun Kim, H. Jerome Coyne
Publikováno v:
The Journal of biological chemistry. 294(8)
Zinc is an essential trace element that serves as a cofactor for enzymes in critical biochemical processes and also plays a structural role in numerous proteins. Zinc transporter ZIP4 (ZIP4) is a zinc importer required for dietary zinc uptake in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b84f9118bf4f8b0246f7ab3b3c3f47
https://pubmed.ncbi.nlm.nih.gov/30593504
https://pubmed.ncbi.nlm.nih.gov/30593504