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Autor:
Yeonjoon Kim, Kyoung Hee Byoun, Miyoung Park, Yong Deog Hong, Yung Hyup Joo, Byung Young Woo, Hyun Ju Koh, Sun-Young Kim, Song Seok Shin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2807-2810
3-Alkyl-2-aryl-2-cyclopenten-1-one oxime derivatives (1) were studied as a novel class of inhibitors of tumor necrosis factor α (TNF-α) with regard to synthesis and in vitro SAR inhibition of TNF-α. The in vitro IC50 values of these compounds in r