Sus1 maintains a normal lifespan through regulation of TREX-2 complex-mediated mRNA export

Autor: Suji Lim, Yan Liu, Byung-Ho Rhie, Chun Kim, Hong-Yeoul Ryu, Seong Hoon Ahn

Publikováno v: Aging. 14(12)

Eukaryotic gene expression requires multiple cellular events, including transcription and RNA processing and transport. Sus1, a common subunit in both the Spt-Ada-Gcn5 acetyltransferase (SAGA) and transcription and export complex-2 (TREX-2) complexes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8763be50273731eab9517745d9e7cc45
https://pubmed.ncbi.nlm.nih.gov/35771153

Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis

Autor: Byung Ho Rhie, Soumyadip Das, Apoorvi Tyagi, Kye Seong Kim, Arun Pandian Chandrasekaran, Suresh Ramakrishna, Seung Jun Oh, Neha Sarodaya, Na Re Ko, Bharathi Suresh, Sang Hyeon Woo

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5766, p 5766 (2021)

Cell division cycle 25A (Cdc25A) is a dual-specificity phosphatase that is overexpressed in several cancer cells and promotes tumorigenesis. In normal cells, Cdc25A expression is regulated tightly, but the changes in expression patterns in cancer cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bbf34c08837c8c1259b55d04bf62ea

E3 Ubiquitin Ligase APC/CCdh1 Regulation of Phenylalanine Hydroxylase Stability and Function

Autor: Byung Ho Rhie, Kamini Kaushal, Arun Pandian Chandrasekaran, Bharathi Suresh, Neha Sarodaya, Suresh Ramakrishna, Kye Seong Kim, Apoorvi Tyagi, Ainsley Mike Antao

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 23
International Journal of Molecular Sciences, Vol 21, Iss 9076, p 9076 (2020)

Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by the dysfunction of the enzyme phenylalanine hydroxylase (PAH). Alterations in the level of PAH leads to the toxic accumulation of phenylalanine in the blood and brain. Prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a550a6a0a380bce00d3a14dc8c2cd86

The RNA polymerase II Rpb4/7 subcomplex regulates cellular lifespan through an mRNA decay process

Autor: Ruxin Duan, Hong-Yeoul Ryu, Byung-Ho Rhie, Seong Hoon Ahn

Publikováno v: Biochemical and biophysical research communications. 441(1)

In budding yeast, a highly conserved heterodimeric protein complex that is composed of the Rpb4 and Rpb7 proteins within RNA polymerase II shuttles between the nucleus and cytoplasm where it coordinates various steps of gene expression by associating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b52761ac0b4909578a4630dc0bfd3b
https://pubmed.ncbi.nlm.nih.gov/24358479