Zobrazeno 1 - 10
of 494
pro vyhledávání: '"Byung‐Hoon Lee"'
Publikováno v:
Cells, Vol 13, Iss 11, p 955 (2024)
Ubiquitin-specific protease 14 (USP14), one of the three major proteasome-associated deubiquitinating enzymes (DUBs), is known to be activated by the AKT-mediated phosphorylation at Ser432. Thereby, AKT can regulate global protein degradation by cont
Externí odkaz:
https://doaj.org/article/4d13bbc13459476995d89c34a7182773
Autor:
You-Jin Choi, Sung Ho Yun, Jihyeon Yu, Yewon Mun, Wonseok Lee, Cheon Jun Park, Byung Woo Han, Byung-Hoon Lee
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101784- (2023)
Objective: Alterations in lipid metabolism are associated with aging and age-related diseases. Chaperone-mediated autophagy (CMA) is a lysosome-dependent process involved in specific protein degradation. Heat shock cognate 71 kDa protein (Hsc70) reco
Externí odkaz:
https://doaj.org/article/f842063dc4164695ae41752f55338e47
Autor:
Sin Ri Kim, Ji Won Park, You-Jin Choi, Seong Keun Sonn, Goo Taeg Oh, Byung-Hoon Lee, Tong-Shin Chang
Publikováno v:
Antioxidants, Vol 13, Iss 1, p 17 (2023)
Nonsteroidal anti-inflammatory drug (NSAID) use is associated with adverse consequences, including hepatic injury. The detrimental hepatotoxicity of diclofenac, a widely used NSAID, is primarily connected to oxidative damage in mitochondria, which ar
Externí odkaz:
https://doaj.org/article/65d057b83abc44c9afb34d6495c73d8c
Autor:
Ka Ying Sharon Hung, Sven Klumpe, Markus R. Eisele, Suzanne Elsasser, Geng Tian, Shuangwu Sun, Jamie A. Moroco, Tat Cheung Cheng, Tapan Joshi, Timo Seibel, Duco Van Dalen, Xin-Hua Feng, Ying Lu, Huib Ovaa, John R. Engen, Byung-Hoon Lee, Till Rudack, Eri Sakata, Daniel Finley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The interplay of the proteasome and deubiquitinase Ubp6 is crucial for the degradation of ubiquitylated substrates. Here, the authors provide structural insights into the allosteric mechanism by which the activities of both Ubp6 and the proteasome ar
Externí odkaz:
https://doaj.org/article/0db17aeb4b8c4a309992d0d564111f7b
Autor:
You-Jin Choi, Hyo-Seon Yang, Yunfan Zhang, Wonseok Lee, Sung Ho Yun, Yoon Ah Nam, Gakyung Lee, Byung Hwa Jung, Tong-Shin Chang, Kyuhong Lee, Byung-Hoon Lee
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 247, Iss , Pp 114213- (2022)
A public health crisis in the form of a significant incidence of fatal pulmonary disease caused by repeated use of humidifier disinfectants containing polyhexamethylene guanidine phosphate (PHMG) recently arose in Korea. Although the mechanisms of pu
Externí odkaz:
https://doaj.org/article/acf83d7dfd2e42a1b9af014bffb82aeb
Autor:
Non-Nuoc Tran, Byung-Hoon Lee
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which motor neurons in spinal cord and motor cortex are progressively lost. About 15% cases of ALS also develop the frontotemporal dementia (FTD), in which the frontotemporal
Externí odkaz:
https://doaj.org/article/7b523a2979284bc5b34e8e71a9f89b96
Autor:
Wonseok Lee, Yewon Mun, Kang-Yo Lee, Jung-Min Park, Tong-Shin Chang, You-Jin Choi, Byung-Hoon Lee
Publikováno v:
Toxics, Vol 11, Iss 9, p 735 (2023)
Mefenamic acid (MFA) is a commonly prescribed non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. MFA is known to have potent antioxidant properties and a neuroprotective effect against oxidative stress. Howe
Externí odkaz:
https://doaj.org/article/fd1e37006ea64b8db4cc29cd72522b86
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1435 (2023)
Ultraviolet B (UVB) irradiation generates reactive oxygen species (ROS), which can damage exposed skin cells. Mitochondria and NADPH oxidase are the two principal producers of ROS in UVB-irradiated keratinocytes. Peroxiredoxin V (PrxV) is a mitochond
Externí odkaz:
https://doaj.org/article/320d6ff528844ebc8d008898512d7af4
Autor:
Hyun Young Kim, Ga Hee Baek, Wonseok Lee, Young Joo Lee, Wan Seob Shim, Young Jae Choi, Byung‐Hoon Lee, Sang Kyum Kim, Keon Wook Kang
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 5, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/5198ca322edc45fa9f9c4dbfafcc1d8a
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 356 (2023)
An aptamer is a single-stranded DNA or RNA that binds to a specific target with high binding affinity. Aptamers are developed through the process of systematic evolution of ligands by exponential enrichment (SELEX), which is repeated to increase the
Externí odkaz:
https://doaj.org/article/2639bdce5b3a4520b543dcac9039d232