Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection.

Autor: Rosa C Coldbeck-Shackley, Ornella Romeo, Sarah Rosli, Linden J Gearing, Jodee A Gould, San S Lim, Kylie H Van der Hoek, Nicholas S Eyre, Byron Shue, Sarah A Robertson, Sonja M Best, Michelle D Tate, Paul J Hertzog, Michael R Beard

Publikováno v: PLoS Pathogens, Vol 19, Iss 3, p e1010843 (2023)

The immunological surveillance factors controlling vulnerability of the female reproductive tract (FRT) to sexually transmitted viral infections are not well understood. Interferon-epsilon (IFNɛ) is a distinct, immunoregulatory type-I IFN that is co

Externí odkaz: https://doaj.org/article/5466e29dbea44bb9bb2a994a75c3a117

Viperin is an important host restriction factor in control of Zika virus infection

Autor: Kylie H. Van der Hoek, Nicholas S. Eyre, Byron Shue, Onruedee Khantisitthiporn, Kittirat Glab-Ampi, Jillian M. Carr, Matthew J. Gartner, Lachlan A. Jolly, Paul Q. Thomas, Fatwa Adikusuma, Tanja Jankovic-Karasoulos, Claire T. Roberts, Karla J. Helbig, Michael R. Beard

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Abstract Zika virus (ZIKV) infection has emerged as a global health threat and infection of pregnant women causes intrauterine growth restriction, spontaneous abortion and microcephaly in newborns. Here we show using biologically relevant cells of ne

Externí odkaz: https://doaj.org/article/31b52a34fd5a49c7bd204c6693170547

Genome-Wide CRISPR Screen Identifies RACK1 as a Critical Host Factor for Flavivirus Replication

Autor: Stephen Pederson, Nicholas S. Eyre, Sonja Frölich, Ralf Bartenschlager, Byron Shue, Emily N. Kirby, Thu-Hien To, Berati Cerikan, Michael R. Beard, Abhilash I. Chiramel, Sonja M. Best

Publikováno v: Journal of Virology

Cellular factors have important roles in all facets of the flavivirus replication cycle. Deciphering viral-host protein interactions is essential for understanding the flavivirus life cycle as well as development of effective antiviral strategies. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c70193949c314d3be217cfdb059602e
https://doi.org/10.1128/jvi.00596-21

Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response

Autor: Byron Shue, Colt W Nash, Kylie H. Van der Hoek, Nicholas S. Eyre, Karla J. Helbig, Cynthia B Whitchurch, Onruedee Khantisitthiporn, Lynne Turnbull, Michael R. Beard

Publikováno v: Life Science Alliance

This work highlights the multifunctional role of the ISG viperin and its interaction with the peroxisomal protein Pex19 to modulate peroxisomal-dependent innate signaling that ultimately restricts viral infection.
Peroxisomes are recognized as s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a60a1e779cde44a382e54ea4fb9aaf
https://pubmed.ncbi.nlm.nih.gov/34108265

Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection.

Autor: Coldbeck-Shackley, Rosa C.¹ (AUTHOR), Romeo, Ornella¹ (AUTHOR), Rosli, Sarah^2,3 (AUTHOR), Gearing, Linden J.^2,3 (AUTHOR), Gould, Jodee A.^2,3 (AUTHOR), Lim, San S.^2,3 (AUTHOR), Van der Hoek, Kylie H.¹ (AUTHOR), Eyre, Nicholas S.¹ (AUTHOR), Shue, Byron¹ (AUTHOR), Robertson, Sarah A.⁴ (AUTHOR), Best, Sonja M.⁵ (AUTHOR), Tate, Michelle D.^2,3 (AUTHOR), Hertzog, Paul J.^2,3 (AUTHOR) paul.hertzog@hudson.org.au, Beard, Michael R.¹ (AUTHOR) paul.hertzog@hudson.org.au

Publikováno v: PLoS Pathogens. 3/10/2023, Vol. 18 Issue 3, p1-26. 26p.