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Akademický článek

Protein-Based Adjuvants for Vaccines as Immunomodulators of the Innate and Adaptive Immune Response: Current Knowledge, Challenges, and Future Opportunities

Autor: Diego A. Díaz-Dinamarca, Michelle L. Salazar, Byron N. Castillo, Augusto Manubens, Abel E. Vasquez, Fabián Salazar, María Inés Becker

Publikováno v: Pharmaceutics, Vol 14, Iss 8, p 1671 (2022)

New-generation vaccines, formulated with subunits or nucleic acids, are less immunogenic than classical vaccines formulated with live-attenuated or inactivated pathogens. This difference has led to an intensified search for additional potent vaccine

Externí odkaz: https://doaj.org/article/a79ffd4ac05b43c49d295b339fb52ba5

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Akademický článek

The relative influences of phosphometabolites and pH on action potential morphology during myocardial reperfusion: a simulation study.

Autor: Byron N Roberts, David J Christini

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e47117 (2012)

Myocardial ischemia-reperfusion (IR) injury represents a constellation of pathological processes that occur when ischemic myocardium experiences a restoration of perfusion. Reentrant arrhythmias, which represent a particularly lethal manifestation of

Externí odkaz: https://doaj.org/article/aa11d8d8781a471486983fee70573309

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Akademický článek

NHE inhibition does not improve Na(+) or Ca(2+) overload during reperfusion: using modeling to illuminate the mechanisms underlying a therapeutic failure.

Autor: Byron N Roberts, David J Christini

Publikováno v: PLoS Computational Biology, Vol 7, Iss 10, p e1002241 (2011)

Reperfusion injury results from pathologies of cardiac myocyte physiology that develop when previously ischemic myocardium experiences a restoration of normal perfusion. Events in the development of reperfusion injury begin with the restoration of a

Externí odkaz: https://doaj.org/article/e2210c65c06548518518355f66deefc4

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