Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Byron Miyazawa"'
1
Akademický článek
Regulation of vascular endothelial integrity by mesenchymal stem cell extracellular vesicles after hemorrhagic shock and trauma
Autor: Mark Barry, Alpa Trivedi, Byron Miyazawa, Lindsay R. Vivona, David Shimmin, Praneeti Pathipati, Callie Keane, Joseph Cuschieri, Shibani Pati
Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Patients with hemorrhagic shock and trauma (HS/T) are vulnerable to the endotheliopathy of trauma (EOT), characterized by vascular barrier dysfunction, inflammation, and coagulopathy. Cellular therapies such as mesenchymal stem ce
Externí odkaz: https://doaj.org/article/c8bd7452549440c2bfeb089721eaa409
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2
Akademický článek
Bone marrow donor selection and characterization of MSCs is critical for pre-clinical and clinical cell dose production
Autor: Alpa Trivedi, Byron Miyazawa, Stuart Gibb, Kristen Valanoski, Lindsay Vivona, Maximillian Lin, Daniel Potter, Mars Stone, Philip J. Norris, James Murphy, Sawyer Smith, Martin Schreiber, Shibani Pati
Publikováno v: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-16 (2019)
Abstract Background Cell based therapies, such as bone marrow derived mesenchymal stem cells (BM-MSCs; also known as mesenchymal stromal cells), are currently under investigation for a number of disease applications. The current challenge facing the
Externí odkaz: https://doaj.org/article/0d26eb3b48944b93917f70bd0e5121f0
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3
Akademický článek
Lyophilized plasma attenuates vascular permeability, inflammation and lung injury in hemorrhagic shock.
Autor: Shibani Pati, Zhanglong Peng, Katherine Wataha, Byron Miyazawa, Daniel R Potter, Rosemary A Kozar
Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0192363 (2018)
In severe trauma and hemorrhage the early and empiric use of fresh frozen plasma (FFP) is associated with decreased morbidity and mortality. However, utilization of FFP comes with the significant burden of shipping and storage of frozen blood product
Externí odkaz: https://doaj.org/article/ddd8b326733e4c18893e2ecfe648913e
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4
Histone deacetylase-6 modulates the effects of 4°C platelets on vascular endothelial permeability
Autor: Byron Miyazawa, Alpa Trivedi, Lindsay Vivona, Maximillian Lin, Daniel Potter, Alison Nair, Mark Barry, Andrew P. Cap, Shibani Pati
Publikováno v: Blood Adv
Blood advances, vol 7, iss 7
Platelets (PLTs) stored at 4°C exhibit equivalent or superior hemostatic function compared with 22°C PLTs, but have shorter circulation times and a decreased ability to modulate vascular permeability. These differences may be due to morphological c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13a7a367888f10e3e9bed4d7a6fa9ac
https://doi.org/10.1182/bloodadvances.2022007409
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5
An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice
Autor: Byron Miyazawa, Mitchell J. Cohen, Charles T. Esmon, Bilgimol Chumappumkal Joseph, Laurent O. Mosnier, Annette von Drygalski
Publikováno v: Blood Advances. 6:959-969
Acute traumatic coagulopathy (ATC) occurs in approximately 30% of patients with trauma and is associated with increased mortality. Excessive generation of activated protein C (APC) and hyperfibrinolysis are believed to be driving forces for ATC. Two
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433af8ff580a171800eaac687c5acb73
https://doi.org/10.1182/bloodadvances.2021005257
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6
The effects of human prothrombin complex concentrate on hemorrhagic shock-induced lung injury in rats: Implications for testing human blood products in rodents
Autor: Maximillian Lin, Alison B Nair, Daniel R. Potter, Martin A. Schreiber, Belinda H. McCully, Lindsay R. Vivona, Shibani Pati, Alpa Trivedi, Byron Miyazawa
Publikováno v: Journal of Trauma and Acute Care Surgery. 89:1068-1075
BACKGROUND Hemorrhagic shock (HS) and trauma can result in an endotheliopathy of trauma, characterized by endothelial compromise, inflammation, and aberrant coagulation. Kcentra, a prothrombin concentrate, has been demonstrated to mitigate pulmonary
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5814f95b6e620e70c18e2ab2f474383
https://doi.org/10.1097/ta.0000000000002890
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7
Platelet-derived- Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock
Autor: Yao-Wei Wang, Shibani Pati, Amit K. Srivastava, Padma Priya Togarrati, Charles E. Wade, Erika Gonzalez, Byron Miyazawa, Jessica C. Cardenas, John Burchfield, Ernesto Lopez, John B. Holcomb
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Every year more than 500,000 deaths are attributed to trauma worldwide and severe hemorrhage is present in most of them. Transfused platelets have been shown to improve survival in trauma patients, although its mechanism is only partially known. Plat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfbd3f76a8d883d5feb60044ea3e6af9
http://link.springer.com/article/10.1038/s41598-019-53724-y
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8
Bone marrow donor selection and characterization of MSCs is critical for pre-clinical and clinical cell dose production
Autor: Kristen Valanoski, Alpa Trivedi, Sawyer Smith, Stuart L. Gibb, Lindsay R. Vivona, Daniel R. Potter, James Murphy, Martin A. Schreiber, Shibani Pati, Philip J. Norris, Maximillian Lin, Byron Miyazawa, Mars Stone
Publikováno v: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-16 (2019)
Journal of Translational Medicine
Journal of translational medicine, vol 17, iss 1
Background Cell based therapies, such as bone marrow derived mesenchymal stem cells (BM-MSCs; also known as mesenchymal stromal cells), are currently under investigation for a number of disease applications. The current challenge facing the field is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4bb3e700ebfd16b2178ef39d8c4098
http://link.springer.com/article/10.1186/s12967-019-1877-4
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9
Cryoprecipitate attenuates the endotheliopathy of trauma in mice subjected to hemorrhagic shock and trauma
Autor: Deborah M. Stein, Lindsay R. Vivona, Mark E. Barry, Michelle G Gatmaitan, Shibani Pati, Rosemary A. Kozar, Praneeti Pathipati, Haoqian Zhang, Alpa Trivedi, Manisha A. Khakoo, Anil Bagri, Byron Miyazawa
Publikováno v: J Trauma Acute Care Surg
BACKGROUND Plasma has been shown to mitigate the endotheliopathy of trauma. Protection of the endothelium may be due in part to fibrinogen and other plasma-derived proteins found in cryoprecipitate; however, the exact mechanisms remain unknown. Clini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8dbcdad8ed2982b074e1fc0c17451f
https://pubmed.ncbi.nlm.nih.gov/33797484
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10
Freeze-dried platelets promote clot formation, attenuate endothelial cell permeability, and decrease pulmonary vascular leak in a murine model of hemorrhagic shock
Autor: Martin A. Schreiber, Shibani Pati, Matthew Dickerson, Manisha A. Khakoo, Daniel R. Potter, Maximillian Lin, Lindsay R. Vivona, Alpa Trivedi, Ben Antebi, Glen Michael Fitzpatrick, Rosemary A. Kozar, Amber Lee, Byron Miyazawa, John B. Holcomb, Braden Ishler
Publikováno v: The journal of trauma and acute care surgery. 90(2)
Background Hemorrhagic shock (HS) and trauma induce endothelial barrier compromise, inflammation, and aberrant clotting. We have shown that fresh human platelets (Plts) and Plt extracellular vesicles mitigate vascular leak in murine models of injury.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf88a600fa45c54d6c2d6eb6c077ee67
https://pubmed.ncbi.nlm.nih.gov/33060537
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