Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Byron H. Arison"'
Autor:
Jin-Jye Feng, Elizabeth T. Birzin, Amos B. Smith, Atsui Lin, Fong-Chi Cheng, Edward R. Thornton, Ralph Hirschmann, Byron H. Arison, Laurie L. Taylor, Santhosh Neelamkavil, Kuo-Hsin Chen
Publikováno v:
Journal of Medicinal Chemistry. 48:4025-4030
An alanine scan performed in the 1970s suggested that Phe(6) and Phe(11) are required for the binding of somatostatin (SRIF-14). Molecular modeling studies and replacement of Phe(6) and Phe(11) with a cystine bridge affording ligands with the retenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a3c75c848207ef2bab7efbdd46af3f4
https://doi.org/10.1021/jm058184l
https://doi.org/10.1021/jm058184l
Autor:
Matthew P. Braun, Thomayant Prueksaritanont, Michael A. Wallace, Byron H. Arison, Xiao Yu, Donghui Cui, James A. Yergey, Raju Subramanian, Magang Shou
Publikováno v:
Drug Metabolism and Disposition. 32:848-861
Compound A (3-[2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyrindin-2-yl)propyl]-imidazolidin-1-yl]-3(S)-(6-methoxy-pyridin-3-yl)-propionic acid), a potent and selective antagonist of integrin alpha(v)beta(3) receptor, is under development for treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b276a48204e837a4069b655f46c159
https://doi.org/10.1124/dmd.32.8.848
https://doi.org/10.1124/dmd.32.8.848
Autor:
Tomoyuki Oe, Byron H. Arison, Michael Pollack, Maria Victoria Silva Elipe, Seon Hwa Lee, Ian A. Blair
Publikováno v:
Chemical Research in Toxicology. 16:893-900
Analysis of the reaction between 2'-deoxycytidine and 4-oxo-2-nonenal by LC/MS revealed the presence of three major products (adducts A(1), A(2), and B; [M + H](+) = 364). Adducts A(1) and A(2) were isomeric, and each dehydrated to form adduct B. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2870772df0a26aaa0f8ee6eb0377464
https://doi.org/10.1021/tx030009p
https://doi.org/10.1021/tx030009p
Publikováno v:
Biopolymers. 68:512-527
Melanocortin receptor 4 (MC-4R) is involved in the regulation of energy balance and body weight, and recognizes alpha-, beta-, and gamma-melanocyte stimulating hormones (alpha-, beta-, gamma-MSH). In the search for compounds that regulate food intake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d4701e68ccf46bf7f514ae7451bff6
https://doi.org/10.1002/bip.10340
https://doi.org/10.1002/bip.10340
Autor:
Bradley K. Wong, Thomas A. Baillie, Jiunn H. Lin, Paul G. Pearson, Rominder Singh, Byron H. Arison, Xiao Yu, Maria Victoria Silva Elipe, Rebecca B. White, Christopher S. Burgey
Publikováno v:
Chemical Research in Toxicology. 16:198-207
Compound I, (2-[3-[(2,2-difluoro-2(2-pyridyl)ethyl)amino]-6-methyl-2-oxohydropyrazinyl]-N-[(3-fluoro(2-pyridyl))methyl]acetamide, is a potent competitive inhibitor of thrombin that reacts stoichiometrically with the protease. Compounds of this class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0361b2b251c6f3f64bc5a4f5c155fcd4
https://doi.org/10.1021/tx025635l
https://doi.org/10.1021/tx025635l
Autor:
Byron H. Arison, David H. Weinberg, Maria V. Silva, Rubana N. Kalyani, Maria A. Bednarek, Tanya MacNeil, Ruey-Ruey C. Huang
Publikováno v:
Peptides. 20:401-409
The alanine-substituted and the retro, enantio, and retro-enantio analogs of MT-II, a potent agonist at melanocortin (MC) receptors, were prepared by solid-phase synthesis and evaluated for their ability to bind and activate human MC3, MC4, and MC5 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabe56f4d0ce14c0f314fc0227e0637b
https://doi.org/10.1016/s0196-9781(99)00048-0
https://doi.org/10.1016/s0196-9781(99)00048-0
Autor:
Joseph A. Potenza, Thomas J. Emge, Spencer Knapp, Harvey J. Schugar, Jayasree Vasudevan, Byron H. Arison
Publikováno v:
Angewandte Chemie. 110:2537-2540
Das Kernstuck des bakteriellen Lichtsammelsystems wird durch ein Porphyrindimer als Modellverbindung nachgeahmt (zentrale Teilstruktur siehe Bild). Dieses Dimer wurde gezielt so synthetisiert, das wie beim naturlichen Pendant nur die π-Elektronensys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8f0a67c248492ec2f517556f9b85a70
https://doi.org/10.1002/(sici)1521-3757(19980904)110:17<2537::aid-ange2537>3.0.co
https://doi.org/10.1002/(sici)1521-3757(19980904)110:17<2537::aid-ange2537>3.0.co
Autor:
Roger M. Freidinger, Byron H. Arison, Roy G. Smith, Kevin T. Chapman, Kang Cheng, Arthur A. Patchett, Alexander Pasternak, Yanping Pan, Elizabeth T. Birzin, Rupa M. Parmar, Scott C. Berk, Maria A. de Souza Silva, Forrest Foor, Liangqin Guo, James M. Schaeffer, Tsuei-Ju Wu, Sudha W. Mitra, Bridgette S. Butler, Susan P. Rohrer, Edward C. Hayes, Lihu Yang, Ralph T. Mosley, Dennis J. Underwood
Publikováno v:
Proceedings of the National Academy of Sciences. 95:10836-10841
A series of nonpeptide somatostatin agonists which bind selectively and with high affinity to somatostatin receptor subtype 2 (sst2) have been synthesized. One of these compounds, L-054,522, binds to human sst2 with an apparent dissociation constant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2248ba0d424ebf80bd10e3290e6a51a
https://doi.org/10.1073/pnas.95.18.10836
https://doi.org/10.1073/pnas.95.18.10836
Publikováno v:
The Journal of Organic Chemistry. 63:2591-2596
The first synthesis of 1,19-aza-1,19-desoxy-avermectin B(1a) (2) is described. This new macrolactam, prepared efficiently from avermectin B(1a) (1a) in seven steps, was designed to form an intramolecular hydrogen bond between the amide carbonyl and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f88447cff24101aa3d0584716ec03ea
https://doi.org/10.1021/jo972094+
https://doi.org/10.1021/jo972094+
Autor:
Christopher L. Wrzesinski, Loretta R. S. Allen, Debra Luffer-Atlas, Byron H. Arison, Mohammad Mushtaq, Amechi C. Chukwudebe
Publikováno v:
Journal of Agricultural and Food Chemistry. 46:1181-1191
The half-life of [14C]4‘‘-deoxy-4‘‘-(epi-methylamino)avermectin B1a (MAB1a) benzoate (1 ppm) photodegradation in buffer (pH 7), natural pond water, and sensitized buffer (1% acetone in pH 7 buffer) determined at Three Bridges, NJ (latitude
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d35b3106c9610538d59a3dc0ab30391b
https://doi.org/10.1021/jf970561i
https://doi.org/10.1021/jf970561i