Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Byron H Hartman"'
Autor:
Branden R Nelson, Yumi Ueki, Sara Reardon, Mike O Karl, Sean Georgi, Byron H Hartman, Deepak A Lamba, Thomas A Reh
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22817 (2011)
Previous studies have shown that Müller glia are closely related to retinal progenitors; these two cell types express many of the same genes and after damage to the retina, Müller glia can serve as a source for new neurons, particularly in non-mamm
Externí odkaz:
https://doaj.org/article/e5ac9243eca14e74a3cd7a08e853bc23
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 242-254 (2018)
Summary: The mammalian hair follicle arises during embryonic development from coordinated interactions between the epidermis and dermis. It is currently unclear how to recapitulate hair follicle induction in pluripotent stem cell cultures for use in
Externí odkaz:
https://doaj.org/article/7107136308d44e19bfcd847c6d5c36b3
Autor:
Byron H. Hartman, Sawa Keymeulen, Robert Böscke, Stefan Heller, Daniel C. Ellwanger, Mirko Scheibinger
While the mouse has been a productive model for inner ear studies, the lack of highly specific genes and tools have presented challenges, specifically forin vitrostudies of otic development, where innate cellular heterogeneity and disorganization inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e749119ee84b45acbd8f17b232f4bb
Autor:
Roman D. Laske, Jörg Waldhaus, Byron H. Hartman, Stefan Heller, Robert Durruthy-Durruthy, Assaf Gottlieb, Russ B. Altman
Publikováno v:
Cell. 157(4):964-978
SummaryThe otocyst harbors progenitors for most cell types of the mature inner ear. Developmental lineage analyses and gene expression studies suggest that distinct progenitor populations are compartmentalized to discrete axial domains in the early o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def9319d1091999d1bbb61bcdca50b15
Autor:
Verdon Taylor, Thomas A. Reh, Olivia Bermingham-McDonogh, Branden R. Nelson, Onur Basak, Byron H. Hartman
Publikováno v:
JARO: Journal of the Association for Research in Otolaryngology
The Notch signaling pathway is known to have multiple roles during development of the inner ear. Notch signaling activates transcription of Hes5, a homologue of Drosophila hairy and enhancer of split, which encodes a basic helix-loop-helix transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe0bc68f5fe39cccb18e8301250d886
https://doi.org/10.1007/s10162-009-0162-2
https://doi.org/10.1007/s10162-009-0162-2
Autor:
Thomas A. Reh, Byron H. Hartman, Toshinori Hayashi, Catherine A. Ray, Olivia Bermingham-McDonogh, Hiroki Kokubo
Publikováno v:
Developmental Biology. 316(1):87-99
In cochlear development, the Notch signaling pathway is required for both the early prosensory phase and a later lateral inhibition phase. While it is known that Hes genes are important downstream mediators of Notch function in lateral inhibition, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be96da844ca3ddccab1d3871f00bb325
Publikováno v:
Developmental Biology. 304(2):479-498
In the developing nervous system, the balance between proliferation and differentiation is critical to generate the appropriate numbers and types of neurons and glia. Notch signaling maintains the progenitor pool throughout this process. While many c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545bec25b96a1fe008d542403ac86712
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Vertebrate embryogenesis gives rise to all cell types of an organism through the development of many unique lineages derived from the three primordial germ layers. The otic sensory lineage arises from the otic vesicle, a structure formed through inva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dca2abf0869661141a84fcd41d39511
http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00079/full
http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00079/full
Publikováno v:
Developmental Neuroscience. 28:128-141
The Notch signaling pathway is important at several stages of retinal development including the differentiation of retinal ganglion cells and Müller glia. The downstream effectors of Notch signaling, Hes1 and Hes5, have been shown to be critical in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591f9178aea0855f3edde2ca4a4b614e
https://doi.org/10.1159/000090759
https://doi.org/10.1159/000090759
Autor:
Roman D. Laske, Renjie Chai, Saku T. Sinkkonen, Felix Gahlen, Byron H. Hartman, Wera Sinkkonen, Stefan Heller, Kazuo Oshima, Alan G. Cheng, Taha A. Jan
Publikováno v:
Scientific Reports
The lack of cochlear regenerative potential is the main cause for the permanence of hearing loss. Albeit quiescent in vivo, dissociated non-sensory cells from the neonatal cochlea proliferate and show ability to generate hair cell-like cells in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a42e3c08e9f6164b35f3e74bde12c4
https://pubmed.ncbi.nlm.nih.gov/22355545
https://pubmed.ncbi.nlm.nih.gov/22355545