Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Byron E, Butterworth"'
Autor:
Byron E. Butterworth, John Chapman
Publikováno v:
Regulatory Toxicology and Pharmacology. 49:149-153
Stem cells for transplantation are obtained from bone marrow, umbilical cord blood, and peripheral blood. A rare complication of hematopoietic stem cell transplantation is donor cell-derived leukemia (DCL). The donors remain cancer free and the cause
Publikováno v:
Regulatory Toxicology and Pharmacology. 49:138-148
1,4-Dichlorobenzene (DCB) induced liver cancer in male and female B6C3F(1) mice in a gavage bioassay and in male and female BDF(1) mice in an inhalation bioassay. The weight of the evidence convincingly indicates that the mouse liver tumors induced b
Publikováno v:
International Journal of Toxicology. 23:335-344
Anthraquinone (AQ) (9,10-anthracenedione) is an important compound in commerce. Many structurally related AQ derivatives are medicinal natural plant products. Examples include 1-hydroxyanthraquinone (1-OH-AQ) and 2-hydroxyanthraquinone (2-OH-AQ), whi
Publikováno v:
Transfusion. 43:1386-1393
BACKGROUND: The novel PEN110 chemistry (INACTINE, V.I. Technologies) process for the purification of blood for transfusions involves treating WBC-reduced RBCs with PEN110 to inactivate a wide spectrum of pathogens. The washed RBC preparation has a re
Publikováno v:
Toxicological Sciences. 75:192-200
Chloroform is a nongenotoxic-cytotoxic carcinogen in rodents. As such, events related to cytotoxicity are the driving force for cancer induction. In this paper we extended an existing physiologically based pharmacokinetic (PBPK) model for chloroform
Publikováno v:
Mutagenesis. 16:169-177
Commercial anthraquinone (AQ) (9,10-anthracenedione) is produced by at least three different production methods worldwide: oxidation of anthracene (AQ-OX), Friedel-Crafts technology (AQ-FC) and by Diels-Alder chemistry (AQ-DA), with the final product
Autor:
Leslie Recio, Byron E. Butterworth, Alexander A. Constan, Linda J. Pluta, Brian A. Wong, Michael V. Templin, Jeffrey I. Everitt, Catherine S. Sprankle
Publikováno v:
Environmental and Molecular Mutagenesis. 31:248-256
The weight of evidence indicates that chloroform induces cancer in the female B6C3F 1 mouse liver via a nongenotoxic-cytotoxic mode of action. However, it is probable that DNA damage occurs secondary to events associated with cytolethality and regene
Autor:
Michael V. Templin, Alexander A. Constan, Brian A. Wong, Byron E. Butterworth, Douglas C. Wolf
Publikováno v:
Carcinogenesis. 19:187-193
mice by inhalation for 2 years at concentrations of 5, 30or 90 p.p.m. for 6 h/day, 5 days/week induced an increasein renal cell tumors in male but not female mice exposedto the doses of 30 and 90 p.p.m. A small increase in livertumors was statistical
Publikováno v:
Molecular Carcinogenesis. 20:288-297
The nongenotoxic-cytotoxic carcinogen chloroform induces liver necrosis, regenerative cell proliferation, and, eventually, liver tumors in female B6C3F1 mice when administered by gavage at doses of 238 or 477 mg/kg/d. Administration of 1800 ppm of ch
Autor:
Byron E. Butterworth, Douglas C. Wolf
Publikováno v:
Toxicologic Pathology. 25:49-52
The development of scientifically sound risk assessments based on mechanistic data will enable society to better allocate scarce resources. Inadequate risk assessments may result in potentially dangerous levels of hazardous chemicals, whereas overly