Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Byron Carpenter"'
Autor:
Byron Carpenter
Publikováno v:
AIMS Bioengineering, Vol 5, Iss 4, Pp 209-225 (2018)
G protein-coupled receptors (GPCRs) regulate intracellular signalling pathways that contribute to virtually all aspects of cell function. Characterising GPCRs in each of their conformational states is key to understanding their mechanism of action, b
Externí odkaz:
https://doaj.org/article/dc8427e9951c47b7af1730ad61c1f5ed
Publikováno v:
eLife, Vol 7 (2018)
The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS. Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecul
Externí odkaz:
https://doaj.org/article/8d680e6ec950444e8faa3bf12c4f8e4a
Autor:
Byron Carpenter, Guillaume Lebon
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Adenosine receptors (ARs) comprise the P1 class of purinergic receptors and belong to the largest family of integral membrane proteins in the human genome, the G protein-coupled receptors (GPCRs). ARs are classified into four subtypes, A1, A2A, A2B,
Externí odkaz:
https://doaj.org/article/b6e85bdca89f4c49be3021d20a5439aa
Autor:
Byron Carpenter, Christopher Tate
Publikováno v:
Bio-Protocol, Vol 7, Iss 8 (2017)
G protein-coupled receptors (GPCRs) promote cytoplasmic signalling by activating heterotrimeric G proteins in response to extracellular stimuli such as light, hormones and nucleosides. Structure determination of GPCR–G protein complexes is central
Externí odkaz:
https://doaj.org/article/8a97e72901bf4c498d52ae94be1528bc
Autor:
Byron Carpenter, Christopher Tate
Publikováno v:
Bio-Protocol, Vol 7, Iss 8 (2017)
Heterotrimeric G proteins modulate intracellular signalling by transducing information from cell surface G protein-coupled receptors (GPCRs) to cytoplasmic effector proteins. Structural and functional characterisation of GPCR–G protein complexes is
Externí odkaz:
https://doaj.org/article/e586503d27f84faca35919c9fa09eddf
Autor:
Rony Nehmé, Byron Carpenter, Ankita Singhal, Annette Strege, Patricia C Edwards, Courtney F White, Haijuan Du, Reinhard Grisshammer, Christopher G Tate
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175642 (2017)
Mini-G proteins are the engineered GTPase domains of Gα subunits. They couple to GPCRs and recapitulate the increase in agonist affinity observed upon coupling of a native heterotrimeric G protein. Given the small size and stability of mini-G protei
Externí odkaz:
https://doaj.org/article/a5fac57f40484242b84cb93eef39e9ee
Autor:
Byron Carpenter
Publikováno v:
The Biochemist. 43:90-91
Science policy can be broadly defined as a two-way dialogue between science-related sectors and government. It involves the exchange of scientific findings and opinions with policy makers to inform the decision-making process, as well as the scrutini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c38a4a645b3768a07fb7f43f4b2e6009
https://doi.org/10.1042/bio_2021_182
https://doi.org/10.1042/bio_2021_182
Autor:
Qingwen Wan, Christopher G. Tate, Rony Nehmé, Najeah Okashah, Byron Carpenter, Asuka Inoue, Nevin A. Lambert
Publikováno v:
The Journal of Biological Chemistry
G protein–coupled receptors (GPCRs) are key signaling proteins that regulate nearly every aspect of cell function. Studies of GPCRs have benefited greatly from the development of molecular tools to monitor receptor activation and downstream signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0e9aed8996e8becdb07d861e0d3a90
https://doi.org/10.1074/jbc.ra118.001975
https://doi.org/10.1074/jbc.ra118.001975
Autor:
Christopher G. Tate, Byron Carpenter
Publikováno v:
Current Opinion in Structural Biology. 45:124-132
G protein-coupled receptors (GPCRs) regulate cellular signalling through heterotrimeric G proteins and arrestins in response to an array of extracellular stimuli. Structure determination of GPCRs in an active conformation bound to intracellular signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8902fecbd2a7f29352fe1f7f9b5f20e
https://doi.org/10.1016/j.sbi.2017.04.010
https://doi.org/10.1016/j.sbi.2017.04.010
Publikováno v:
Nature
An engineered G protein is used to bind to and stabilize the active conformation of the adenosine A2A receptor, enabling the acquisition of an X-ray crystal structure of this GPCR in an active state. G-protein-coupled receptors (GPCRs) are essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6132ec42a548fd6c77590b1149251e91
http://europepmc.org/articles/PMC4979997
http://europepmc.org/articles/PMC4979997