Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Byron C. Williams"'
Autor:
Alan Sulpizio, Marena E Minelli, Min Wan, Paul D Burrowes, Xiaochun Wu, Ethan J Sanford, Jung-Ho Shin, Byron C Williams, Michael L Goldberg, Marcus B Smolka, Yuxin Mao
Publikováno v:
eLife, Vol 8 (2019)
Pseudokinases are considered to be the inactive counterparts of conventional protein kinases and comprise approximately 10% of the human and mouse kinomes. Here, we report the crystal structure of the Legionella pneumophila effector protein, SidJ, in
Externí odkaz:
https://doaj.org/article/526ea497678244118ca94ce0c4b7c0ab
Publikováno v:
eLife, Vol 6 (2017)
The small phosphoprotein pCPI-17 inhibits myosin light-chain phosphatase (MLCP). Current models postulate that during muscle relaxation, phosphatases other than MLCP dephosphorylate and inactivate pCPI-17 to restore MLCP activity. We show here that s
Externí odkaz:
https://doaj.org/article/d68ffed44dc74ee285db39b682874364
Autor:
Byron C Williams, Joshua J Filter, Kristina A Blake-Hodek, Brian E Wadzinski, Nicholas J Fuda, David Shalloway, Michael L Goldberg
Publikováno v:
eLife, Vol 3 (2014)
During M phase, Endosulfine (Endos) family proteins are phosphorylated by Greatwall kinase (Gwl), and the resultant pEndos inhibits the phosphatase PP2A-B55, which would otherwise prematurely reverse many CDK-driven phosphorylations. We show here tha
Externí odkaz:
https://doaj.org/article/cbc61139874c4097b350db9fa5c17e5d
Autor:
Jung-Ho Shin, Marcus B. Smolka, Byron C. Williams, Alan Sulpizio, Michael L. Goldberg, Paul D Burrowes, Yuxin Mao, Ethan J. Sanford, Min Wan, Marena E. Minelli, Xiaochun Wu
Publikováno v:
eLife, Vol 8 (2019)
Pseudokinases are considered to be the inactive counterparts of conventional protein kinases and comprise approximately 10% of the human and mouse kinomes. Here we report the crystal structure of theLegionella pneumophilaeffector protein, SidJ, in co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61adb3cc55f0d89f45c4c1b0f24d9bd4
Autor:
Francesca Cipressa, Michael L. Goldberg, Maurizio Gatti, Silvia Bonaccorsi, Giovanni Cenci, Lucia Graziadio, Byron C. Williams, Valeria Palumbo
Publikováno v:
Chromosoma (Berl., Print) 127 (2018): 489–504. doi:10.1007/s00412-018-0680-y
info:cnr-pdr/source/autori:Graziadio L.; Palumbo V.; Cipressa F.; Williams B.C.; Cenci G.; Gatti M.; Goldberg M.L.; Bonaccorsi S./titolo:Phenotypic characterization of diamond (dind), a Drosophila gene required for multiple aspects of cell division/doi:10.1007%2Fs00412-018-0680-y/rivista:Chromosoma (Berl., Print)/anno:2018/pagina_da:489/pagina_a:504/intervallo_pagine:489–504/volume:127
info:cnr-pdr/source/autori:Graziadio L.; Palumbo V.; Cipressa F.; Williams B.C.; Cenci G.; Gatti M.; Goldberg M.L.; Bonaccorsi S./titolo:Phenotypic characterization of diamond (dind), a Drosophila gene required for multiple aspects of cell division/doi:10.1007%2Fs00412-018-0680-y/rivista:Chromosoma (Berl., Print)/anno:2018/pagina_da:489/pagina_a:504/intervallo_pagine:489–504/volume:127
Many genes are required for the assembly of the mitotic apparatus and for proper chromosome behavior during mitosis and meiosis. A fruitful approach to elucidate the mechanisms underlying cell division is the accurate phenotypic characterization of m
Autor:
Byron C. Williams, Michael L. Goldberg, Aimin Peng, Ling Wang, Jing Zhao, Dapeng Ren, Laura A. Fisher
Publikováno v:
The Journal of biological chemistry. 292(24)
Greatwall (Gwl) kinase plays an essential role in the regulation of mitotic entry and progression. Mitotic activation of Gwl requires both cyclin-dependent kinase 1 (CDK1)-dependent phosphorylation and its autophosphorylation at an evolutionarily con
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
The small phosphoprotein pCPI-17 inhibits myosin light-chain phosphatase (MLCP). Current models postulate that during muscle relaxation, phosphatases other than MLCP dephosphorylate and inactivate pCPI-17 to restore MLCP activity. We show here that s
Autor:
James L. Maller, Byron C. Williams, Michael L. Goldberg, Andrea L. Lewellyn, Kristina A. Blake-Hodek, Tomomi M. Yamamoto
Publikováno v:
Molecular Biology of the Cell
Greatwall kinase is required for M phase maintenance by inhibiting PP2A. Gwl associates with PP2A in G2 oocytes, but the complex dissociates during M phase (meiosis I). Mutating Lys71 to Met (K71M) generates gain-of-function Gwl kinase activity towar
Autor:
Maria Grazia Giansanti, Violaine Mottier, Silvia Bonaccorsi, Byron C. Williams, Bonnie J. Bolkan, Michael L. Goldberg, Maurizio Gatti
Publikováno v:
Development (Camb.) 134 (2007): 2183–2193. doi:10.1242/dev.02848
info:cnr-pdr/source/autori:Bonaccorsi S, Mottier V, Giansanti MG, Bolkan BJ, Williams B, Goldberg ML, Gatti M./titolo:The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division./doi:10.1242%2Fdev.02848/rivista:Development (Camb.)/anno:2007/pagina_da:2183/pagina_a:2193/intervallo_pagine:2183–2193/volume:134
info:cnr-pdr/source/autori:Bonaccorsi S, Mottier V, Giansanti MG, Bolkan BJ, Williams B, Goldberg ML, Gatti M./titolo:The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division./doi:10.1242%2Fdev.02848/rivista:Development (Camb.)/anno:2007/pagina_da:2183/pagina_a:2193/intervallo_pagine:2183–2193/volume:134
We have isolated lethal mutations in the Drosophila lkb1 gene(dlkb1), the homolog of C. elegans par-4 and human LKB1 (STK11), which is mutated in Peutz-Jeghers syndrome. We show that these mutations disrupt spindle formation, resulting in frequent po