Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Byron B. Au-Yeung"'
Publikováno v:
Nature Immunology. 24:136-147
Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C-γ (PLCγ1) represents a critical step in T cell antigen receptor (TCR) signaling and subsequent thymocyte and T cell responses. PIP2 replenishment following its depletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97a76bdd367405dd307d65b372dee49e
https://doi.org/10.1038/s41590-022-01372-2
https://doi.org/10.1038/s41590-022-01372-2
Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness
Autor:
Joel Eggert, Wendy M. Zinzow-Kramer, Yuesong Hu, Yuan-Li Tsai, Arthur Weiss, Khalid Salaita, Christopher D. Scharer, Byron B. Au-Yeung
Publikováno v:
bioRxiv
The cumulative effects of T cell receptor (TCR) signal transduction over extended periods of time influences T cell biology, such as the positive selection of immature thymocytes or the proliferative responses of naive T cells. Naive T cells experien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412bd5cb34aa739c6ba074a49d2d9de6
https://europepmc.org/articles/PMC9900884/
https://europepmc.org/articles/PMC9900884/
Autor:
Byron B. Au-Yeung, Joel Eggert
Publikováno v:
Curr Opin Immunol
Mature CD4(+) and CD8(+) T cells constitutively experience weak T cell receptor (TCR) stimulation in response to self-antigens, termed tonic (or basal) signaling. How tonic TCR signal strength impacts T cell responses to foreign antigens is an active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a9ad8eed164e7ca6c50c8987b89449
https://doi.org/10.1016/j.coi.2021.09.007
https://doi.org/10.1016/j.coi.2021.09.007
Autor:
Wendy M. Zinzow-Kramer, Elizabeth M. Kolawole, Joel Eggert, Brian D. Evavold, Christopher D. Scharer, Byron B. Au-Yeung
Publikováno v:
ImmunoHorizons. 6(9)
T cells experience varying intensities of tonic or basal TCR signaling in response to self-peptides presented by MHC (self-pMHC) in vivo. We analyzed four subpopulations of mouse naive CD4sup+/supcells that express different levels of Nur77-GFP and L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4417f46894458687b7cb71038e1f2c3b
https://pubmed.ncbi.nlm.nih.gov/36100367
https://pubmed.ncbi.nlm.nih.gov/36100367
Tonic TCR signaling occurs constitutively in response to self-peptides presented by MHC (pMHC). Tonic TCR signal intensity correlates with Nur77-GFP reporter transgene expression. A broad range of Nur77-GFP is first detectable in post-selection thymo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::118710d3f7d50993445a038d42e7e46a
https://doi.org/10.1101/2022.04.20.488956
https://doi.org/10.1101/2022.04.20.488956
Publikováno v:
Proceedings of the National Academy of Sciences. 116:15160-15169
Naïve CD4(+) T cells experience weak T cell receptor (TCR) signals induced by self-peptides presented by MHC II. To investigate how these “basal” TCR signals influence responses to agonist TCR ligand stimulation, we analyzed naïve CD4(+) cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173d0adfd4f25c192b13e30877f80ed7
https://doi.org/10.1073/pnas.1904096116
https://doi.org/10.1073/pnas.1904096116
Autor:
Hyewon Phee, Byron B Au-Yeung, Olga Pryshchep, Kyle Leonard O'Hagan, Stephanie Grace Fairbairn, Maria Radu, Rachelle Kosoff, Marianne Mollenauer, Debra Cheng, Jonathan Chernoff, Arthur Weiss
Publikováno v:
eLife, Vol 3 (2014)
The molecular mechanisms that govern thymocyte development and maturation are incompletely understood. The P21-activated kinase 2 (Pak2) is an effector for the Rho family GTPases Rac and Cdc42 that regulate actin cytoskeletal remodeling, but its role
Externí odkaz:
https://doaj.org/article/0f47d51dd4a94e00b110b8cfba0b5ab7
Autor:
Misty R Jenkins, Jane C Stinchcombe, Byron B Au-Yeung, Yukako Asano, Alex T Ritter, Arthur Weiss, Gillian M Griffiths
Publikováno v:
eLife, Vol 3 (2014)
T cell receptor (TCR) activation leads to a dramatic reorganisation of both membranes and receptors as the immunological synapse forms. Using a genetic model to rapidly inhibit Zap70 catalytic activity we examined synapse formation between cytotoxic
Externí odkaz:
https://doaj.org/article/e70e5a1f66ad48a2831d41bc26545289
Publikováno v:
The Journal of Immunology. 208:166.12-166.12
Before emerging as functional T lymphocytes, thymocytes transit through multiple selection stages during which T cell antigen receptor (TCR) signaling controls the survival and subsequent maturation. Hydrolysis of phosphatidylinositol 4,5-biphosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73a3f86a74b993acdbca25cdad3fe3ee
https://doi.org/10.4049/jimmunol.208.supp.166.12
https://doi.org/10.4049/jimmunol.208.supp.166.12
Publikováno v:
The Journal of Immunology. 208:167.12-167.12
Naive T cells constantly experience tonic or basal TCR signals in response to self-peptides presented by MHC (pMHC) in vivo. We aimed to define how tonic TCR signaling impacts naive CD4+ T cells at the functional, transcriptional, and epigenetic leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7366a871e464e259d3ec1b539c599091
https://doi.org/10.4049/jimmunol.208.supp.167.12
https://doi.org/10.4049/jimmunol.208.supp.167.12