Výsledky vyhledávání - "Byron A. Boyce"

CDP840. A prototype of a novel class of orally active anti-Inflammatory phosphodiesterase 4 inhibitors

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 12:1451-1456

The discovery, synthesis and biological activity of a series of triarylethane phosphodiesterase 4 inhibitors is described. Structure-activity relationship studies are presented for CDP840 (29), a potent, chiral, selective inhibitor of PDE 4 (IC(50) 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d1a5dd3d9373fea6d98706204952b2
https://doi.org/10.1016/s0960-894x(02)00202-0

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An in Vivo Model for Screening Peptidomimetic Inhibitors of Gelatinase A

Autor: James O'Connell, Byron A. Boyce, Pari Antoniw, John Robert Porter, Andrew Mountain, Surinder K. Chander, Kenneth Millar, Richard Morphy, Barbara Mason, Neville Willmott, Nigel Robert Arnold Beeley, Joanna Leonard, Thomas Crabbe, Andrew T. Millican, Andrew J. P. Docherty

Publikováno v: Journal of Pharmaceutical Sciences. 84:404-409

Gelatinase A, a matrix metalloproteinase, is frequently associated with human solid tumors, and its secretion and activation in the tumor milieu is considered important in the process of angiogenesis, invasion, and metastasis. Consequently, metallopr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b9d49b17daa1ab88c55ae679150c8a
https://doi.org/10.1002/jps.2600840405

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Potent and selective inhibitors of gelatinase-A 2. carboxylic and phosphonic acid derivatives

Autor: Byron A. Boyce, Nigel Robert Arnold Beeley, J. Richard Morphy, Andrew T. Millican, Joanna Leonard, Barbara Mason, Kenneth Millar, John Robert Porter, O'connell James Philip

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:2747-2752

A series of zinc binding groups was introduced into a pseudopeptide sequence containing aromatic groups in the P1′ position in order to obtain selective inhibitors of gelatinase-A. Carboxylic acid and phosphonic acid groups provided the most potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cb5c9f340d96dd6d0ec92d0ab252ea4
https://doi.org/10.1016/s0960-894x(01)80588-6

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Potent and selective inhibitors of gelatinase-a 1. hydroxamic acid derivatives

Autor: Kenneth Millar, Joanna Leonard, O'connell James Philip, Andrew T. Millican, Byron A. Boyce, J. Richard Morphy, Barbara Mason, John Robert Porter, Nigel Robert Arnold Beeley

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:2741-2746

A series of hydroxamic acid derivatives were prepared. By introducing aromatic substituents at the P1′ and P3′ positions highly potent gelatinase-A inhibitors, which possess a high degree of selectivity over collagenase and stromelysin, were obta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38749fe0dc2358bdc8bfcbcf20b91e62
https://doi.org/10.1016/s0960-894x(01)80587-4

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Synthesis of New Macrocyclic Amino-Phosphinic Acid Complexing Agents and TheirC-andP-Functionalised Derivatives for Protein Linkage

Autor: Nigel Robert Arnold Beeley, Andrew T. Millican, Christopher J. Broan, David Parker, Kanthi Pulukkody, Kenneth Millar, Eleanor Cole, Karl J. Jankowski, Byron A. Boyce

Publikováno v: Synthesis. 1992:63-68

The synthesis of various macrocyclic complexing agents with alkyland arylphosphinic substituents is reported together with their C- and N-functionalised analogues as active esters suitable for antibody conjugation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::105dd026b9fc29103be4ca3497a02273
https://doi.org/10.1055/s-1992-34177

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Towards tumour imaging with indium-111 labelled macrocycle–antibody conjugates

Autor: Andrew S. Craig, Andrew T. Millican, Alice Harrison, I. M. Helps, Alison Phipps, SK Rhind, Nigel Robert Arnold Beeley, Kenneth Millar, Byron A. Boyce, C Walker, Michael Anthony William Eaton, Karl J. Jankowski, David Parker

Publikováno v: J. Chem. Soc., Chem. Commun.. :794-796

C-Functionalised triazacyclododecane and triazacyclononane triacid macrocycles have been covalently attached to a monoclonal antibody and may be labelled with 111In to form kinetically inert radiolabelled complexes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26d3441f61f8d8f0a97c596cf29fe2fb
https://doi.org/10.1039/c39890000794

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ChemInform Abstract: HETEROTOPIC LIGANDS: SYNTHESIS AND COMPLEXATION PROPERTIES OF PHOSPHINE-FUNCTIONALIZED DIPODAL MACROCYCLES

Autor: David Parker, Jean-Marie Lehn, Byron A. Boyce, Annick Carroy

Publikováno v: Chemischer Informationsdienst. 16

The synthesis of a series of phosphine-functionalized dipodal macrocycles is described; prior co-ordination of a cation within the macrocyclic cavity regulates the ligand structure aiding fotmation of heterodinuclear complexes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db9e0c6e358d0982b08d4c456b3c7d2b
https://doi.org/10.1002/chin.198514299

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Synthesis of a kinetically stable yttrium-90 labelled macrocycle–antibody conjugate

Autor: Nigel Robert Arnold Beeley, Kenneth Millar, Michael Anthony William Eaton, Byron A. Boyce, Karl J. Jankowski, Ritu Kataky, Alice Harrison, C Walker, Jonathan P. L. Cox, David Parker, Andrew T. Millican

Publikováno v: J. Chem. Soc., Chem. Commun.. :797-798

Lysine is a precursor for the synthesis of an aminobutyl C-functionalised tetra-azacyclododecane tetra-acid which has been linked to B72.3 antibody and may be labelled with 90Y to form a kinetically stable complex of potential use in radioimmunothera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43a0508afdf4bcb9144434aee6b655d2
https://doi.org/10.1039/c39890000797

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