Synthesis of TGF-Beta inhibitors and compounds for spatiotemporal drug release

Autor: Byrom, Daniel

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
TDX (Tesis Doctorals en Xarxa)
TDR. Tesis Doctorales en Red
instname

[eng] During this doctoral thesis, we have synthesised hundreds of grams of the TGF-β inhibitor LY2157299 (Galunisertib). This product was used by the group of Eduard Batlle in their investigations into the roles that TGF-β plays in colorectal canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2d3ad053fca528088df0adcd6436617f
http://hdl.handle.net/2445/127606

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.

Autor: Tauriello, Daniele V. F., Palomo-Ponce, Sergio, Stork, Diana, Berenguer-Llergo, Antonio, Badia-Ramentol, Jordi, Iglesias, Mar, Sevillano, Marta, Ibiza, Sales, Cañellas, Adrià, Hernando-Momblona, Xavier, Byrom, Daniel, Matarin, Joan A., Calon, Alexandre, Rivas, Elisa I., Nebreda, Angel R., Riera, Antoni, Attolini, Camille Stephan-Otto, Batlle, Eduard

Publikováno v: Nature; 2/22/2018, Vol. 554 Issue 7693, p538-543, 6p, 2 Color Photographs, 12 Graphs

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Immunostaining Protocol: P-Stat3 (Xenograft and Mice).

Autor: Calon A; Oncology Programme, Institute for Research in Biomedicine, Barcelona, Spain., Espinet E; Oncology Programme, Institute for Research in Biomedicine, Barcelona, Spain., Palomo-Ponce S; Oncology Programme, Institute for Research in Biomedicine, Barcelona, Spain., Tauriello DVF; Oncology Programme, Institute for Research in Biomedicine, Barcelona, Spain., Iglesias M; Department of Pathology, Hospital Universitari del Mar, Barcelona, Spain., Céspedes MV; IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Sevillano M; IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Nadal C; Institut de Malalties Hemato-Oncològiques, Hospital Clínic, Barcelona, Spain., Jung P; Institut de Malalties Hemato-Oncològiques, Hospital Clínic, Barcelona, Spain., Zhang XH; Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, USA., Byrom D; Chemistry and Molecular Pharmacology Programme, Institute for Research in Biomedicine, Barcelona, Spain., Riera A; Chemistry and Molecular Pharmacology Programme, Institute for Research in Biomedicine, Barcelona, Spain., Rossell D; Biostatistics and Bioinformatics Unit, Institute for Research in Biomedicine, Barcelona, Spain., Mangues R; Biostatistics and Bioinformatics Unit, Institute for Research in Biomedicine, Barcelona, Spain., Massague J; Biostatistics and Bioinformatics Unit, Institute for Research in Biomedicine, Barcelona, Spain., Sancho E; Biostatistics and Bioinformatics Unit, Institute for Research in Biomedicine, Barcelona, Spain., Batlle E; Biostatistics and Bioinformatics Unit, Institute for Research in Biomedicine, Barcelona, Spain.

Publikováno v: Bio-protocol [Bio Protoc] 2014 May 05; Vol. 4 (9).