Zobrazeno 1 - 10
of 584
pro vyhledávání: '"Byrne Helen M"'
Autor:
Walker, Benjamin J., Byrne, Helen M.
The logistic equation is ubiquitous in applied mathematics as a minimal model of saturating growth. Here, we examine a generalisation of the logistic model to fitness-structured populations, motivated by examples that range from the ageing of individ
Externí odkaz:
http://arxiv.org/abs/2410.01862
Epigenetics plays a key role in cellular differentiation and maintaining cell identity, enabling cells to regulate their genetic activity without altering the DNA sequence. Epigenetic regulation occurs within the context of hierarchically folded chro
Externí odkaz:
http://arxiv.org/abs/2409.06116
Macrophages in atherosclerotic lesions exhibit a spectrum of behaviours or phenotypes. The phenotypic distribution of monocyte-derived macrophages (MDMs), its correlation with MDM lipid content, and relation to blood lipoprotein densities are not wel
Externí odkaz:
http://arxiv.org/abs/2404.07051
Interstitial fluid flow is a feature of many solid tumours. In vitro Experiments have shown that such fluid flow can direct tumour cell movement upstream or downstream depending on the balance between the competing mechanisms of tensotaxis and autolo
Externí odkaz:
http://arxiv.org/abs/2309.13982
Autor:
Stolz, Bernadette J., Dhesi, Jagdeep, Bull, Joshua A., Harrington, Heather A., Byrne, Helen M., Yoon, Iris H. R.
Topological data analysis (TDA) is an active field of mathematics for quantifying shape in complex data. Standard methods in TDA such as persistent homology (PH) are typically focused on the analysis of data consisting of a single entity (e.g., cells
Externí odkaz:
http://arxiv.org/abs/2308.06205
Autor:
Yang, Jingjie, Fang, Heidi, Dhesi, Jagdeep, Yoon, Iris H. R., Bull, Joshua A., Byrne, Helen M., Harrington, Heather A., Grindstaff, Gillian
The complex and dynamic crosstalk between tumour and immune cells results in tumours that can exhibit distinct qualitative behaviours - elimination, equilibrium, and escape - and intricate spatial patterns, yet share similar cell configurations in th
Externí odkaz:
http://arxiv.org/abs/2308.05294
Publikováno v:
WIREs Mechanisms of Disease, e1634 (2023)
Angiogenesis is the process wherein endothelial cells (ECs) form sprouts that elongate from the pre-existing vasculature to create new vascular networks. In addition to its essential role in normal development, angiogenesis plays a vital role in path
Externí odkaz:
http://arxiv.org/abs/2307.10297
Cancer is a heterogeneous disease and tumours of the same type can differ greatly at the genetic and phenotypic levels. Understanding how these differences impact sensitivity to treatment is an essential step towards patient-specific treatment design
Externí odkaz:
http://arxiv.org/abs/2302.13298
Organoids are multi-cellular structures which are cultured in vitro from stem cells to resemble specific organs (e.g., brain, liver) in their three-dimensional composition. Dynamic changes in the shape and composition of these model systems can be us
Externí odkaz:
http://arxiv.org/abs/2212.10883
Atherosclerotic plaques form in artery walls due to a chronic inflammatory response driven by lipid accumulation. A key component of the inflammatory response is the interaction between monocyte-derived macrophages and extracellular lipid. Although c
Externí odkaz:
http://arxiv.org/abs/2212.03859