Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington's disease mice.

Autor: Caron, Nicholas S.^1,2,3 (AUTHOR), Byrne, Lauren M.⁴ (AUTHOR), Lemarié, Fanny L.^1,2,3 (AUTHOR), Bone, Jeffrey N.^2,5 (AUTHOR), Aly, Amirah E.-E.^1,2,3 (AUTHOR), Ko, Seunghyun¹ (AUTHOR), Anderson, Christine¹ (AUTHOR), Casal, Lorenzo L.¹ (AUTHOR), Hill, Austin M.¹ (AUTHOR), Hawellek, David J.⁶ (AUTHOR), McColgan, Peter⁷ (AUTHOR), Wild, Edward J.⁴ (AUTHOR), Leavitt, Blair R.^1,2,3 (AUTHOR), Hayden, Michael R.^1,2,3 (AUTHOR) mrh@cmmt.ubc.ca

Publikováno v: Translational Neurodegeneration. 10/8/2024, Vol. 13 Issue 1, p1-22. 22p.

Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington's disease Young Adult Study (HD-YAS): a cross-sectional analysis

Autor: Scahill, Rachael I, Zeun, Paul, Osborne-Crowley, Katherine, Johnson, Eileanoir B, Gregory, Sarah, Parker, Christopher, Lowe, Jessica, Nair, Akshay, O'Callaghan, Claire, Langley, Christelle, Papoutsi, Marina, McColgan, Peter, Estevez-Fraga, Carlos, Fayer, Kate, Wellington, Henny, Rodrigues, Filipe B, Byrne, Lauren M, Heselgrave, Amanda, Hyare, Harpreet, Sampaio, Cristina, Zetterberg, Henrik, Zhang, Hui, Wild, Edward J, Rees, Geraint, Robbins, Trevor W, Sahakian, Barbara J, Langbehn, Douglas, Tabrizi, Sarah J ^*

Publikováno v: In The Lancet Neurology June 2020 19(6):502-512

Clinical Review of Juvenile Huntington's Disease.

Autor: Oosterloo, Mayke, Touze, Alexiane, Byrne, Lauren M., Achenbach, Jannis, Aksoy, Hande, Coleman, Annabelle, Lammert, Dawn, Nance, Martha, Nopoulos, Peggy, Reilmann, Ralf, Saft, Carsten, Santini, Helen, Squitieri, Ferdinando, Tabrizi, Sarah, Burgunder, Jean-Marc, Quarrell, Oliver

Publikováno v: Journal of Huntington's Disease; 2024, Vol. 13 Issue 2, p149-161, 13p

Translatable plasma and CSF biomarkers for use in mouse models of Huntington's disease.

Autor: Bondulich, Marie K, Phillips, Jemima, Cañibano-Pico, María, Nita, Iulia M, Byrne, Lauren M, Wild, Edward J, Bates, Gillian P

Publikováno v: Brain Communications; 2024, Vol. 6 Issue 1, p1-15, 15p

Additional file 2 of A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer’s disease

Autor: Boeddrich, Annett, Haenig, Christian, Neuendorf, Nancy, Blanc, Eric, Ivanov, Andranik, Kirchner, Marieluise, Schleumann, Philipp, Bayraktaroğlu, Irem, Richter, Matthias, Molenda, Christine Mirjam, Sporbert, Anje, Zenkner, Martina, Schnoegl, Sigrid, Suenkel, Christin, Schneider, Luisa-Sophie, Rybak-Wolf, Agnieszka, Kochnowsky, Bianca, Byrne, Lauren M., Wild, Edward J., Nielsen, Jørgen E., Dittmar, Gunnar, Peters, Oliver, Beule, Dieter, Wanker, Erich E.

Additional file 2: Fig. S1. Aβ peptide levels and APP and PSEN1 expression in hippocampus and cortex of 5xFAD mice. Fig. S2. Analysis of Aβ aggregate formation using membrane filter assays and sucrose gradient centrifugations. Fig. S3. Analysis of

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