Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

Autor: Byrne, Kate m., Monsefi, Naser, Dawson, John, Degasperi, Andrea, Bukowski-wills, Jimi-carlo, Volinsky, Natalia, Dobrzyński, Maciej, Birtwistle, Marc r., Tsyganov, Mikhail a., Kiyatkin, Anatoly, Kida, Katarzyna, Finch, Andrew J., Carragher, Neil O., Kolch, Walter, Nguyen, Lan k., von Kriegsheim, Alex, Kholodenko, Boris n.

Publikováno v: Byrne, K, Monsefi, N, Dawson, J, Degasperi, A, Bukowski-wills, J, Volinsky, N, Dobrzyński, M, Birtwistle, M, Tsyganov, M, Kiyatkin, A, Kida, K, Finch, A J, Carragher, N O, Kolch, W, Nguyen, L, von Kriegsheim, A & Kholodenko, B 2016, ' Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches ', Cell Systems, vol. 2, no. 1, pp. 38-48 . https://doi.org/10.1016/j.cels.2016.01.003

SummaryDynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modeling, mass spectrometry-based quantitation of network components, and exp

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