Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Byrne, HM"'
Publikováno v:
Proceedings of the IEEE. 110:523-540
Over the past 25 years, there has been an unparalleled increase in understanding of cancer biology. This transformation is exemplified by Hanahan and Weinberg’s decision in 2011 to expand their original Hallmarks of Cancer from six traits to ten! A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4559328d73925328a2c7b2a3472ed7c0
https://doi.org/10.1109/jproc.2021.3136715
https://doi.org/10.1109/jproc.2021.3136715
Cancer is a heterogeneous disease and tumours of the same type can differ greatly at the genetic and phenotypic levels. Understanding how these differences impact sensitivity to treatment is an essential step towards patient-specific treatment design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a580145acaf3519d0c8a780857775ed
http://arxiv.org/abs/2302.13298
http://arxiv.org/abs/2302.13298
\emph{In vitro} experiments in which tumour cells are seeded in a gelatinous medium, or hydrogel, show how mechanical interactions between tumour cells and the tissue in which they are embedded, together with local levels of an externally-supplied, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cfd3fb45e305d7a6bb14c3163cf52e
The MEK/ERK signalling pathway is involved in cell division, cell specialisation, survival and cell death (Shaul and Seger in Biochim Biophys Acta (BBA)-Mol Cell Res 1773(8):1213–1226, 2007). Here we study a polynomial dynamical system describing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61140304c73abb8b75581bbd88c74faa
Publikováno v:
Journal of Computational Physics. 449:110781
In upscaling methods, closures for nonlinear problems present a well-known challenge. While a number of theoretical methods have been proposed for handling such closures, nonlinearities still remain a significant obstacle for many problems. In this w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edddc58e70e5a9eff2e7f7a7ccbf9783
https://doi.org/10.1016/j.jcp.2021.110781
https://doi.org/10.1016/j.jcp.2021.110781
Neovascular age-related macular degeneration (wet AMD) results from the pathological angiogenesis of choroidal capillaries, which leak fluid within or below the macular region of the retina. The current standard of care for treating wet AMD utilizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8c0fb95ea0d83a4737da9508eb2c2c7b
https://doi.org/10.1021/acs.molpharmaceut.8b00280
https://doi.org/10.1021/acs.molpharmaceut.8b00280
Purpose To determine whether the oxygen toxicity hypothesis can explain the distinctive spatio-temporal patterns of retinal degeneration associated with human retinitis pigmentosa (RP) and to predict the effects of antioxidant and trophic factor trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fbf4673b78397ede73c22bd74e7fcb7d
https://doi.org/10.1167/iovs.17-23177
https://doi.org/10.1167/iovs.17-23177
Publikováno v:
Biology Direct, Vol 5, Iss 1, p 27 (2010)
Abstract Background Investigations of solid tumours suggest that vessel occlusion may occur when increased pressure from the tumour mass is exerted on the vessel walls. Since immature vessels are frequently found in tumours and may be particularly se
Externí odkaz:
https://doaj.org/article/22d9546702644981b52ced580ba997a7