AHCC ^® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections.

Autor: Smith JA; Department of Obstetrics, Gynecology and Reproductive Sciences, UT Health McGovern Medical School, Houston, TX, United States.; Department of Pharmacy, UT Heath-Memorial Hermann Cancer Center, Houston, TX, United States., Gaikwad AA; Department of Obstetrics, Gynecology and Reproductive Sciences, UT Health McGovern Medical School, Houston, TX, United States., Mathew L; Department of Obstetrics, Gynecology and Reproductive Sciences, UT Health McGovern Medical School, Houston, TX, United States., Rech B; UT Physicians Women's Center, Houston, TX, United States., Faro JP; Specialists in Obstetrics & Gynecology, Houston, TX, United States., Lucci JA 3rd; Department of Obstetrics, Gynecology and Reproductive Sciences, UT Health McGovern Medical School, Houston, TX, United States.; Department of Pharmacy, UT Heath-Memorial Hermann Cancer Center, Houston, TX, United States., Bai Y; Department of Pathology, UT Health McGovern Medical School, Houston, TX, United States., Olsen RJ; Department of Molecular Pathology, Houston Methodist Research Institute, Houston, TX, United States., Byrd TT; Department of Obstetrics, Gynecology and Reproductive Sciences, UT Health McGovern Medical School, Houston, TX, United States.

Publikováno v: Frontiers in oncology [Front Oncol] 2022 Jun 22; Vol. 12, pp. 881902. Date of Electronic Publication: 2022 Jun 22 (Print Publication: 2022).

A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma.

Autor: Konduri V; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA., Joseph SK; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA., Byrd TT; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA., Nawas Z; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA., Vazquez-Perez J; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA., Hofferek CJ; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA., Halpert MM; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA., Liu D; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA., Liang Z; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA., Baig Y; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA., Salsman VS; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA., Oyewole-Said D; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA., Tsimelzon A; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Burns BA; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA., Chen C; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Levitt JM; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.; Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA., Yao Q; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.; Michael E. DeBakey VA Medical Center, Center for Translational Research on Inflammatory Diseases (CTRID), Houston, TX 77030, USA., Ahmed NM; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Hegde M; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Decker WK; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA. decker@bcm.edu.; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 May 05; Vol. 13 (592).

Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma.

Autor: Hegde M; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu., Joseph SK; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Pashankar F; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA., DeRenzo C; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Sanber K; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Navai S; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Byrd TT; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Hicks J; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA., Xu ML; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Gerken C; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Kalra M; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Robertson C; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Zhang H; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Shree A; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Mehta B; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Dakhova O; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Salsman VS; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Grilley B; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Gee A; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Dotti G; Department of Microbiology and Immunology at University of North Carolina, Chapel Hill, NC, USA.; Lineberger Cancer Center at University of North Carolina, Chapel Hill, NC, USA., Heslop HE; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Brenner MK; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Wels WS; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany., Gottschalk S; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA., Ahmed N; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.

Publikováno v: Nature communications [Nat Commun] 2020 Jul 15; Vol. 11 (1), pp. 3549. Date of Electronic Publication: 2020 Jul 15.

Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.

Autor: Hegde M, Mukherjee M, Grada Z, Pignata A, Landi D, Navai SA, Wakefield A, Fousek K, Bielamowicz K, Chow KK, Brawley VS, Byrd TT, Krebs S, Gottschalk S, Wels WS, Baker ML, Dotti G, Mamonkin M, Brenner MK, Orange JS, Ahmed N

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2019 Jul 02; Vol. 129 (8), pp. 3464. Date of Electronic Publication: 2019 Jul 02 (Print Publication: 2019).

Retraction Note: A homing system targets therapeutic T cells to brain cancer.

Autor: Samaha H; Children's Cancer Hospital Egypt-57357, Cairo, Egypt.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA., Pignata A; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA., Fousek K; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA.; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA., Ren J; Edwin L. Steele Laboratories for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lam FW; Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Center for Translational Research on Inflammatory Diseases at the Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA., Stossi F; Baylor College of Medicine, Houston, TX, USA.; Integrated Microscopy Core, Advanced Technology Cores, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Dubrulle J; Baylor College of Medicine, Houston, TX, USA.; Integrated Microscopy Core, Advanced Technology Cores, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Salsman VS; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA., Krishnan S; Edwin L. Steele Laboratories for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Hong SH; Department of Neurology, McGovern Medical School at UT Health, Houston, TX, USA., Baker ML; Baylor College of Medicine, Houston, TX, USA.; National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, TX, USA., Shree A; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA., Gad AZ; Children's Cancer Hospital Egypt-57357, Cairo, Egypt.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA.; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA., Shum T; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA.; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA., Fukumura D; Edwin L. Steele Laboratories for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Byrd TT; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA.; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA., Mukherjee M; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA.; Center for Human Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA., Marrelli SP; Department of Neurology, McGovern Medical School at UT Health, Houston, TX, USA., Orange JS; Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Center for Human Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA., Joseph SK; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA., Sorensen PH; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Taylor MD; Developmental and Stem Cell Biology Program, The Arthur and Sonia Labatt Brain Tumour Research Centre, Division of Neurosurgery, Departments of Surgery, Laboratory Medicine and Pathobiology, and of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Hegde M; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA.; Houston Methodist Hospital, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA., Mamonkin M; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA.; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA., Jain RK; Edwin L. Steele Laboratories for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., El-Naggar S; Children's Cancer Hospital Egypt-57357, Cairo, Egypt., Ahmed N; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Texas Children's Hospital, Houston, TX, USA. nahmed@bcm.edu.; Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Houston Methodist Hospital, Houston, TX, USA. nahmed@bcm.edu.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. nahmed@bcm.edu.

Publikováno v: Nature [Nature] 2019 Mar; Vol. 567 (7746), pp. 132.