Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Byram W, Bridle"'
Autor:
Rebecka A. Sadler, Anna K. Shoveller, Umesh K. Shandilya, Armen Charchoglyan, Lauraine Wagter-Lesperance, Byram W. Bridle, Bonnie A. Mallard, Niel A. Karrow
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7001-7031 (2024)
Vitamin K (VK) is an essential micronutrient impacting many systems in the body. This lipid-soluble vitamin is found in various plant and animal products and is absorbed via the lymphatic system. This biomolecule’s importance to human health includ
Externí odkaz:
https://doaj.org/article/ed38150a8bbc43c7a7898aa38d064361
Autor:
Lisa A. Santry, Jacob P. van Vloten, Amanda W. K. AuYeung, Robert C. Mould, Jacob G. E. Yates, Thomas M. McAusland, James J. Petrik, Pierre P. Major, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionTumor microenvironments are immunosuppressive due to progressive accumulation of mutations in cancer cells that can drive expression of a range of inhibitory ligands and cytokines, and recruitment of immunomodulatory cells, including myel
Externí odkaz:
https://doaj.org/article/0dc2b238fb124dce87ad725117251258
Autor:
Jessica A. Minott, Jacob P. van Vloten, Jake G.E. Yates, Lisa A. Santry, Kathy Matuszewska, Madison Pereira, Melanie M. Goens, Alicia M. Viloria-Petit, Geoffrey A. Wood, Khalil Karimi, James J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100748- (2023)
Immunotherapies revive host immune responses against tumors by stimulating innate and adaptive immune effector cells with antitumor functions. Thus, detailed studies of immunological cell phenotypes and functions within the tumor microenvironment (TM
Externí odkaz:
https://doaj.org/article/741bb4cb64894b1a844ac39272790cc9
Autor:
Yeganeh Mehrani, Solmaz Morovati, Tahmineh Tajik, Soroush Sarmadi, Ali Bitaraf, Zahra Sourani, Mohammad Shahverdi, Helia Javadi, Julia E. Kakish, Byram W. Bridle, Khalil Karimi
Publikováno v:
Cells, Vol 13, Iss 5, p 462 (2024)
The skin is a dynamic organ with a complex immune network critical for maintaining balance and defending against various pathogens. Different types of cells in the skin, such as mast cells (MCs) and group 2 innate lymphoid cells (ILC2s), contribute t
Externí odkaz:
https://doaj.org/article/1cba921eddd8476c8a3a7e2b9fb41b41
Autor:
Laura P. van Lieshout, Amira D. Rghei, Wenguang Cao, Shihua He, Geoff Soule, Wenjun Zhu, Sylvia P. Thomas, Debra Sorensen, Kathy Frost, Kevin Tierney, Brad Thompson, Stephanie Booth, David Safronetz, Raveendra R. Kulkarni, Byram W. Bridle, Xiangguo Qiu, Logan Banadyga, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 505-518 (2022)
Filoviruses cause severe hemorrhagic fever with case fatality rates as high as 90%. Filovirus-specific monoclonal antibodies (mAbs) confer protection in nonhuman primates as late as 5 days after challenge, and FDA-approved mAbs REGN-EB3 and mAb114 ha
Externí odkaz:
https://doaj.org/article/50cc389f7095494bba9d58a113335768
Publikováno v:
Vaccines, Vol 11, Iss 10, p 1559 (2023)
Dendritic cell (DC) vaccines can stimulate the immune system to target cancer antigens, making them a promising therapy in immunotherapy. Clinical trials have shown limited effectiveness of DC vaccines, highlighting the need to enhance the immune res
Externí odkaz:
https://doaj.org/article/26c60b2b31d945628eae319542ea0108
Autor:
Sophie Tieu, Armen Charchoglyan, Lauryn Paulsen, Lauri C. Wagter-Lesperance, Umesh K. Shandilya, Byram W. Bridle, Bonnie A. Mallard, Niel A. Karrow
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1867 (2023)
N-acetylcysteine (NAC), an acetylated derivative of the amino acid L-cysteine, has been widely used as a mucolytic agent and antidote for acetaminophen overdose since the 1960s and the 1980s, respectively. NAC possesses antioxidant, cytoprotective, a
Externí odkaz:
https://doaj.org/article/d51a2f369c004cb4881c03dcb3550b04
Autor:
Yeganeh Mehrani, Solmaz Morovati, Sophie Tieu, Negar Karimi, Helia Javadi, Sierra Vanderkamp, Soroush Sarmadi, Tahmineh Tajik, Julia E. Kakish, Byram W. Bridle, Khalil Karimi
Publikováno v:
Cells, Vol 12, Iss 18, p 2271 (2023)
Mast cells (MCs) are abundant at sites exposed to the external environment and pathogens. Local activation of these cells, either directly via pathogen recognition or indirectly via interaction with other activated immune cells and results in the rel
Externí odkaz:
https://doaj.org/article/30495b3946ee49869acfc24df4488f61
Autor:
Jacob P. van Vloten, Jessica A. Minott, Thomas M. McAusland, Joelle C. Ingrao, Lisa A. Santry, Grant McFadden, James J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 434-447 (2021)
Poxviruses have been used extensively as vaccine vectors for human and veterinary medicine and have recently entered the clinical realm as immunotherapies for cancer. We present a comprehensive method for producing high-quality lots of the poxvirus P
Externí odkaz:
https://doaj.org/article/80ee3b897ec94e55bc1c335e48d70703
Autor:
Jessica A. Minott, Jacob P. van Vloten, Jacob G. E. Yates, Lily Chan, Geoffrey A. Wood, Alicia M. Viloria-Petit, Khalil Karimi, James J. Petrik, Sarah K. Wootton, Byram W. Bridle
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Novel immunotherapies continue to be developed and tested for application against a plethora of diseases. The clinical translation of immunotherapies requires an understanding of their mechanisms. The contributions of antibodies in driving long-term
Externí odkaz:
https://doaj.org/article/290daf6e1e214d409b2203e5bfe374a6