Zobrazeno 1 - 10 of 307 pro vyhledávání: '"Byoung-Mog Kwon"'
1
Akademický článek
S-Benproperine, an Active Stereoisomer of Benproperine, Suppresses Cancer Migration and Tumor Metastasis by Targeting ARPC2
Autor: Hyun-Jin Jang, Yae Jin Yoon, Jiyeon Choi, Yu-Jin Lee, Sangku Lee, Wansang Cho, Wan Gi Byun, Seung Bum Park, Dong Cho Han, Byoung-Mog Kwon
Publikováno v: Pharmaceuticals, Vol 15, Iss 12, p 1462 (2022)
Metastasis, in which cancer cells migrate to other tissues and form new tumors, is a major cause of both cancer death and treatment failure. In a previous study, benproperine (Benp) was identified as a cancer cell migration inhibitor and an inhibitor
Externí odkaz: https://doaj.org/article/b9cec002f04240e2aa3504c94c6f7146
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2
Akademický článek
Acacetin Inhibits the Growth of STAT3-Activated DU145 Prostate Cancer Cells by Directly Binding to Signal Transducer and Activator of Transcription 3 (STAT3)
Autor: Sun Yun, Yu-Jin Lee, Jiyeon Choi, Nam Doo Kim, Dong Cho Han, Byoung-Mog Kwon
Publikováno v: Molecules, Vol 26, Iss 20, p 6204 (2021)
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in the formation and growth of human cancer. Therefore, STAT3 is a therapeutic target for cancer drug discovery. Acacetin, a flavone present in various plants, inhibits
Externí odkaz: https://doaj.org/article/c780334438b34125b2e7693f392677af
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3
Data from Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells
Autor: Byoung-Mog Kwon, Dong Cho Han, Seung-Jun Kim, Young Ju Yoon, Ki Deok Shin, Hye-Nan Kim, Dae-Seop Shin
Because signal transducer and activator of transcription 3 (STAT3) is constitutively activated in most human solid tumors and is involved in the proliferation, angiogenesis, immune evasion, and antiapoptosis of cancer cells, researchers have focused
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa40db1b149dd0bfc2c186177490b17c
https://doi.org/10.1158/0008-5472.c.6498389.v1
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6
Acacetin Inhibits the Growth of STAT3-Activated DU145 Prostate Cancer Cells by Directly Binding to Signal Transducer and Activator of Transcription 3 (STAT3)
Autor: Nam Doo Kim, Sun Yun, Jiyeon Choi, Byoung-Mog Kwon, Dong Cho Han, Yu-Jin Lee
Publikováno v: Molecules
Volume 26
Issue 20
Molecules, Vol 26, Iss 6204, p 6204 (2021)
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in the formation and growth of human cancer. Therefore, STAT3 is a therapeutic target for cancer drug discovery. Acacetin, a flavone present in various plants, inhibits
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e932251ada6b29729ca7594f73f5fa7
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7
Targeting HSF1 as a Therapeutic Strategy for Multiple Mechanisms of EGFR Inhibitor Resistance in EGFR Mutant Non-Small-Cell Lung Cancer
Autor: Dong Cho Han, Yu-Jin Lee, Jiyae Jung, Kyung Chan Park, Byoung-Mog Kwon, Sangah Lee, Jung-Ae Kim, Bo Kyung Kim, Seon-Kyu Kim
Publikováno v: Cancers, Vol 13, Iss 2987, p 2987 (2021)
Cancers
Volume 13
Issue 12
Simple Summary We attempted to identify target proteins and compounds that can be used to overcome EGFR-TKI resistance in NSCLC. To accomplish this, we generated EGFR inhibitor erlotinib-resistant HCC827-ErlR cells and obtained a list of differential
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab183c5b355edd3a9db2b093b8430b7
https://www.mdpi.com/2072-6694/13/12/2987
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8
Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2/3 complex
Autor: Yu-Jin Lee, Byoung-Mog Kwon, Jiyeon Choi, Seung-Jin Park, Seon-Young Kim, Dong Cho Han, Cheol-Hee Kim, Nam Doo Kim, Yae Jin Yoon
Publikováno v: Cancer Science
ARPC2 is a subunit of the Arp2/3 complex, which is essential for lamellipodia, invadopodia and filopodia, and ARPC2 has been identified as a migrastatic target molecule. To identify ARPC2 inhibitors, we generated an ARPC2 knockout DLD‐1 human colon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a8b827c2a9c3b2ba86c6b4c303d302
https://doi.org/10.1111/cas.14205
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9
Benproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis
Autor: Seung-Wook Chi, Su-Kyung Lee, Jeong Hee Moon, Chang Woo Lee, Jieun Yun, Yae Jin Yoon, Jiyeon Choi, Yu-Jin Lee, Jong Soon Kang, Sangku Lee, Dong Cho Han, Young-Min Han, Byoung-Mog Kwon
Publikováno v: Biochemical Pharmacology. 163:46-59
Metastasis is the leading cause of cancer mortality and cancer cell migration is an essential stage of metastasis. We identified benproperine (Benp, a clinically used antitussive drug) as an inhibitor of cancer cell migration and an anti-metastatic a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85329ac30c51117579a4322cca431ed
https://doi.org/10.1016/j.bcp.2019.01.017
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10
2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice
Autor: Yuancheng Mao, Eun Ju Bae, Byung-Hyun Park, Byoung-Mog Kwon, Lihua Hao, Jin Park
Publikováno v: Experimental & Molecular Medicine
2′-Hydroxycinnamaldehyde (HCA), the active component isolated from the stem bark of Cinnamomum cassia, exerts anticancer effects through multiple mechanisms. We recently determined that HCA inhibits signal transducer and activator of transcription
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4fef7ed986f6cb56b33a774bf57b31
https://pubmed.ncbi.nlm.nih.gov/33990689
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