Zobrazeno 1 - 10 of 59 pro vyhledávání: '"Bylgja, Hilmarsdottir"'
1
Akademický článek
Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer
Autor: Sigurdur Trausti Karvelsson, Qiong Wang, Bylgja Hilmarsdottir, Arnar Sigurdsson, Siver Andreas Moestue, Gunhild Mari Mælandsmo, Skarphedinn Halldorsson, Steinn Gudmundsson, Ottar Rolfsson
Publikováno v: npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic p
Externí odkaz: https://doaj.org/article/cdfa07e4bd6d4ad0a6994536dab48cac
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2
Akademický článek
Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen
Autor: Anna Barkovskaya, Craig M. Goodwin, Kotryna Seip, Bylgja Hilmarsdottir, Solveig Pettersen, Clint Stalnecker, Olav Engebraaten, Eirikur Briem, Channing J. Der, Siver A. Moestue, Thorarinn Gudjonsson, Gunhild M. Mælandsmo, Lina Prasmickaite
Publikováno v: Molecular Oncology, Vol 15, Iss 8, Pp 2026-2045 (2021)
Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple‐negative breast cancer (TNBC). Here, we use
Externí odkaz: https://doaj.org/article/0cf47b80942b4dccb4f54632467c29f1
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3
Akademický článek
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer
Autor: Maria T. Grinde, Bylgja Hilmarsdottir, Hanna Maja Tunset, Ida Marie Henriksen, Jana Kim, Mads H. Haugen, Morten Beck Rye, Gunhild M. Mælandsmo, Siver A. Moestue
Publikováno v: Breast Cancer Research, Vol 21, Iss 1, Pp 1-13 (2019)
Abstract Introduction Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising
Externí odkaz: https://doaj.org/article/d8b0d0d0cd0e45d1b4bea9d5fd2b95b4
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4
Akademický článek
Hsa-miR-21-3p associates with breast cancer patient survival and targets genes in tumor suppressive pathways
Autor: Arsalan Amirfallah, Hildur Knutsdottir, Adalgeir Arason, Bylgja Hilmarsdottir, Oskar T. Johannsson, Bjarni A. Agnarsson, Rosa B. Barkardottir, Inga Reynisdottir
Publikováno v: PLoS ONE, Vol 16, Iss 11 (2021)
Breast cancer is the cancer most often diagnosed in women. MicroRNAs (MIRs) are short RNA molecules that bind mRNA resulting in their downregulation. MIR21 has been shown to be an oncomiR in most cancer types, including breast cancer. Most of the eff
Externí odkaz: https://doaj.org/article/5bdc640f97234803a0e2debaeb2e4ac0
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5
Akademický článek
Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor Cells
Autor: Zuzana Budkova, Anna Karen Sigurdardottir, Eirikur Briem, Jon Thor Bergthorsson, Snævar Sigurdsson, Magnus Karl Magnusson, Gunnhildur Asta Traustadottir, Thorarinn Gudjonsson, Bylgja Hilmarsdottir
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Epithelial-to-mesenchymal transition (EMT) and its reversed process mesenchymal-to-epithelial transition (MET) play a critical role in epithelial plasticity during development and cancer progression. Among important regulators of these cellular proce
Externí odkaz: https://doaj.org/article/e07a06748c2249c59761666b7b9b3b2d
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6
Advances in lung cancer diagnosis and treatment - a review
Autor: Hronn, Harðardottir, Steinn, Jonsson, Orvar, Gunnarsson, Bylgja, Hilmarsdottir, Jurate, Asmundsson, Ingibjorg, Gudmundsdottir, Vaka Yr, Saevarsdottir, Sif, Hansdottir, Petur, Hannesson, Tomas, Gudbjartsson
Publikováno v: Læknablaðið. 108:17-29
Lung cancer is the second and third most common cancer in Iceland for females and males, respectively. Although the incidence is declining, lung cancer still has the highest mortality of all cancers in Iceland. Symptoms of lung cancer can be specific
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddda69251ff53623b50e75a4c3c9566f
https://doi.org/10.17992/lbl.2022.01.671
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7
Application of 3D Culture Assays to Study Breast Morphogenesis, Epithelial Plasticity, and Cellular Interactions in an Epithelial Progenitor Cell Line
Autor: Anna Karen, Sigurdardottir, Bylgja, Hilmarsdottir, Thorarinn, Gudjonsson, Gunnhildur Asta, Traustadottir
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2429
Capturing breast morphogenesis and cancer progression in 3D culture using cell lines with stem cell properties can greatly increase understanding of the underlying mechanisms involved in these processes, highlighting the importance of the culture met
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43a50e6f8d5d4d0ef117aa7c619173bb
https://pubmed.ncbi.nlm.nih.gov/35507176
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9
Hsa-miR-21-3p associates with breast cancer patient survival and targets genes in tumor suppressive pathways
Autor: Bjarni A. Agnarsson, Arsalan Amirfallah, Oskar T. Johannsson, Adalgeir Arason, Inga Reynisdottir, Bylgja Hilmarsdottir, Hildur Knutsdottir, Rosa B. Barkardottir
Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0260327 (2021)
Breast cancer is the cancer most often diagnosed in women. MicroRNAs (MIRs) are short RNA molecules that bind mRNA resulting in their downregulation. MIR21 has been shown to be an oncomiR in most cancer types, including breast cancer. Most of the eff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173e4ed13513ec5453110f1a8c3e81ca
https://pubmed.ncbi.nlm.nih.gov/34797887
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10
Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer
Autor: Ottar Rolfsson, Bylgja Hilmarsdottir, Steinn Gudmundsson, Qiong Wang, Skarphedinn Halldorsson, Gunhild Mari Mælandsmo, Sigurdur Trausti Karvelsson, Arnar Sigurdsson, Siver Andreas Moestue
Publikováno v: NPJ Systems Biology and Applications
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-10 (2021)
npj Systems Biology and Applications
Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic phenotypes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fb968ca62b55dd3fc418f3482cbd01
https://pubmed.ncbi.nlm.nih.gov/34535676
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