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Akademický článek
Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor
Autor: Jinwoong Kim, Byeongha Choi, Daseul Im, Hoyong Jung, Hyungwoo Moon, Waqar Aman, Jung-Mi Hah
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1314-1320 (2019)
BRAF belongs to the upstream portion of the MAPK pathway, which is involved in cell proliferation and survival. When mutations occur in BRAF, downstream MEK and ERK are phosphorylated irrespective of RAS, resulting in melanoma-like cancer. Over the y
Externí odkaz: https://doaj.org/article/07c5c571304347478ec389292c8ebde7
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2
Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor
Autor: Hyungwoo Moon, Waqar Aman, Daseul Im, Byeongha Choi, Hoyong Jung, Jin Woong Kim, Jung-Mi Hah
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1314-1320 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry
BRAF belongs to the upstream portion of the MAPK pathway, which is involved in cell proliferation and survival. When mutations occur in BRAF, downstream MEK and ERK are phosphorylated irrespective of RAS, resulting in melanoma-like cancer. Over the y
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e881db09e449cf6ff03246801385ba
https://doaj.org/article/07c5c571304347478ec389292c8ebde7
Zobrazit plný text záznamu

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