Administration of OKT3 as a two-hour infusion attenuates first-dose side effects

Autor: Buysmann, S., Hack, C. E., van Diepen, F. N., Surachno, J., ten Berge, I. J.

Publikováno v: Transplantation, 64(11), 1620-1623. Lippincott Williams and Wilkins

BACKGROUND: Use of the murine CD3 monoclonal antibody OKT3 is limited by first-dose side effects, which are thought to be caused by the release of inflammatory mediators. Because these processes might be influenced by the speed of administration, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::aafa894d6891da82239c5dcb7525e406
https://pure.amc.nl/en/publications/administration-of-okt3-as-a-twohour-infusion-attenuates-firstdose-side-effects(d0b30882-7c02-40ed-89f5-52dfa78ffa3d).html

Increased dermal expression of ICAM-1 and VCAM-1 after administration of OKT3 in man

Autor: Buysmann, S., van Diepen, F. N., Surachno, S., Pals, S. T., ten Berge, R. J.

Publikováno v: Clinical nephrology, 46(2), 84-91. Dustri-Verlag Dr. Karl Feistle

OKT3 induces a systemic release of cytokines and a profound peripheral lymphocytopenia. In vitro, tumor necrosis factor-alpha, interleukin-1, and interferon-gamma increase adhesion molecule expression on vascular endothelium. To investigate the effec

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https://pure.amc.nl/en/publications/increased-dermal-expression-of-icam1-and-vcam1-after-administration-of-okt3-in-man(59ed807f-50a3-4dc3-b2ef-d193d13892b6).html

Biphasic granulocytopenia after administration of the first dose of OKT3

Autor: Bemelman, F. J., Buysmann, S., Yong, S. L., van Diepen, F. N., Schellekens, P. T., ten Berge, R. J.

Publikováno v: Journal of laboratory and clinical medicine, 126(6), 571-579. Mosby Inc.

The effects of the administration of OKT3, a second immunoglobulin G2a (IgG2a) anti-CD3 monoclonal antibody (mAb), and its isotype switch variant IgA on granulocyte kinetics were compared for 5 hours after the first administration of the mAb. In addi

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https://pure.amc.nl/en/publications/biphasic-granulocytopenia-after-administration-of-the-first-dose-of-okt3(00d4dfbc-a96d-456a-b4d6-f46d7e67ef53).html

The influence of OKT3 on expression of lymphocyte adhesion molecules in vitro

Autor: Buysmann, S, van Diepen, F N, van Kooyk, Y, ten Berge, R J

Publikováno v: Transplantation proceedings, 26(6), 3249-3250. Elsevier USA
Buysmann, S, van Diepen, F N, van Kooyk, Y & ten Berge, R J 1994, ' The influence of OKT3 on expression of lymphocyte adhesion molecules in vitro ', Transplantation Proceedings, vol. 26, no. 6, pp. 3249-50 .
Transplantation Proceedings, 26(6), 3249-50. Elsevier USA

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https://pure.amc.nl/en/publications/the-influence-of-okt3-on-expression-of-lymphocyte-adhesion-molecules-in-vitro(39ad1332-61bc-4943-8192-f7fb1b9c50bd).html

Activation and increased expression of adhesion molecules on peripheral blood lymphocytes is a mechanism for the immediate lymphocytopenia after administration of OKT3

Autor: Buysmann, S, Bemelman, FJ, Schellekens, PT, van Kooyk, Y, Figdor, CG, ten Berge, IJ

Publikováno v: Blood; January 1996, Vol. 87 Issue: 1 p404-411, 8p