Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Buyan-Ochir Orgil"'
Autor:
Zhaowei Xu, Shuyan Liu, Chun Feng, Fuyi Xu, Demin Kong, Jia Mi, Chunhua Yang, Guilong Zhang, Pengfei Wei, Buyan-Ochir Orgil, Jonas Bergquist, Geng Tian
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Checkpoint suppressor 1 (CHES1), a transcriptional regulator, had been dysregulated in many types of malignancies including breast cancer, and its expression level is strongly associated with progression and prognosis of patients. However, t
Externí odkaz:
https://doaj.org/article/490609138449482d85fc2163fc20f877
Autor:
Akhilesh Kumar Bajpai, Qingqing Gu, Buyan-Ochir Orgil, Fuyi Xu, Carolina Torres-Rojas, Wenyuan Zhao, Chen Chen, Athena Starlard-Davenport, Byron Jones, Djamel Lebeche, Jeffrey A. Towbin, Enkhsaikhan Purevjav, Lu Lu, Wenjing Zhang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundCopper (Cu) is essential for the functioning of various enzymes involved in important cellular and physiological processes. Although critical for normal cardiac function, excessive accumulation, or deficiency of Cu in the myocardium is detr
Externí odkaz:
https://doaj.org/article/79fcbc57e92e45a1ae60a37aac4e3d2e
Autor:
Qingqing Gu, Buyan-Ochir Orgil, Akhilesh Kumar Bajpai, Yufeng Chen, David G. Ashbrook, Athena Starlard-Davenport, Jeffrey A. Towbin, Djamel Lebeche, Enkhsaikhan Purevjav, Hongzhuan Sheng, Lu Lu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12759 (2023)
Background: Troponin-I interacting kinase encoded by the TNNI3K gene is expressed in nuclei and Z-discs of cardiomyocytes. Mutations in TNNI3K were identified in patients with cardiac conduction diseases, arrhythmias, and cardiomyopathy. Methods: We
Externí odkaz:
https://doaj.org/article/505c10670a8244e99f27e59f887a98a1
Autor:
Michelle Chintanaphol, Buyan-Ochir Orgil, Neely R. Alberson, Jeffrey A. Towbin, Enkhsaikhan Purevjav
Publikováno v:
Reviews in Cardiovascular Medicine, Vol 23, Iss 3, p 108 (2022)
Restrictive cardiomyopathy (RCM), a potentially devastating heart muscle disorder, is characterized by diastolic dysfunction due to abnormal muscle relaxation and myocardial stiffness resulting in restrictive filling of the ventricles. Diastolic dysf
Externí odkaz:
https://doaj.org/article/4436ad3fbb064d69b0e2a4b815505c7d
Autor:
Buyan-Ochir Orgil, Fuyi Xu, Undral Munkhsaikhan, Neely R. Alberson, Akhilesh Kumar Bajpai, Jason N. Johnson, Yao Sun, Jeffrey A. Towbin, Lu Lu, Enkhsaikhan Purevjav
Publikováno v:
Physiological Genomics. 55:51-66
The genetic reference population of recombinant inbred BXD mice has been derived from crosses between C57BL/6J and DBA/2J strains. The DBA/2J parent exhibits cardiomyopathy phenotypes, while C57BL/6J has normal heart. BXD mice are sequenced for study
Autor:
Buyan-Ochir Orgil, Undral Munkhsaikhan, Joseph F. Pierre, Ning Li, Fuyi Xu, Neely R. Alberson, Jason N. Johnson, Glenn T. Wetzel, Bastiaan J. D. Boukens, Lu Lu, Jeffrey A. Towbin, Enkhsaikhan Purevjav
Publikováno v:
American journal of physiology. Heart and circulatory physiology, 324(6), H866-H880. American Physiological Society
The transmembrane protein 43 (TMEM43/LUMA) p.S358L mutation causes arrhythmogenic cardiomyopathy named as ARVC5, a fully penetrant disease with high risk of ventricular arrhythmias, sudden death, and heart failure. Male gender and vigorous exercise i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e549d208bc05e1ea7cd5061cac4890ca
https://pure.amc.nl/en/publications/the-tmem43-s358l-mutation-affects-cardiac-small-intestine-and-metabolic-homeostasis-in-a-knockin-mouse-model(2eb9ebf3-9fc9-4392-a555-5b8d395bb2ac).html
https://pure.amc.nl/en/publications/the-tmem43-s358l-mutation-affects-cardiac-small-intestine-and-metabolic-homeostasis-in-a-knockin-mouse-model(2eb9ebf3-9fc9-4392-a555-5b8d395bb2ac).html
Autor:
Buyan-Ochir Orgil, Fuyi Xu, Ning Li, Neely R Alberson, Jason N Johnson, Lea Letourneau, Jeffrey A Towbin, Lu Lu, Enkhsaikhan Purevjav
Publikováno v:
Physiology. 38
Introduction: Heart rhythm disorders or cardiac arrhythmias can cause sudden death and heart failure. Risk factors for cardiac arrhythmias vary including genetics, age, and other environmental and lifestyle factors. To sought how genetic background a
Most prominent functional abnormalities seen in the failing human heart are impaired contraction and slowed rates of relaxation of cardiac cells in the face of increased neurohormonal activation, sustained inflammation, mechanical and volume overload
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20e9dc32eedd28aea78a3a8e30c88bc
https://mts.intechopen.com/articles/show/title/myocardial-remodeling-with-ventricular-assist-devices
https://mts.intechopen.com/articles/show/title/myocardial-remodeling-with-ventricular-assist-devices
Autor:
John Collyer, Lu Lu, John Lynn Jefferies, Jeffrey A. Towbin, Richard J. Czosek, Wenying Zhang, Neely F. Alberson, Buyan-Ochir Orgil, Enkhsaikhan Purevjav, Undral Munkhsaikhan, Fuyi Xu
Publikováno v:
International Journal of Cardiology. 347:29-37
Background Understanding the overall variant burden in pediatric patients with left ventricular noncompaction (LVNC) has clinical implications. Whole exome sequencing (WES) allows detection of coding variants in both candidate cardiomyopathy genes an
Autor:
Buyan-Ochir Orgil, Deli Dong, Brianna Cathey, Dennis Black, Jeffrey A. Towbin, Joseph F. Pierre, Lu Lu, Jaclyn A. Brennan, Qingqing Gu, Fuyi Xu, Igor R. Efimov, Neely R Alberson, Zaza Khuchua, Undral Munkhsaikhan, Jason N. Johnson, Enkhsaikhan Purevjav
Publikováno v:
Physiological Genomics
Broad cellular functions and diseases including muscular dystrophy, arrhythmogenic right ventricular cardiomyopathy (ARVC5) and cancer are associated with transmembrane protein43 (TMEM43/ LUMA). The study aimed to investigate biological roles of TMEM