Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Buwei Huang"'
Autor:
Buwei Huang, Brian Coventry, Marta T. Borowska, Dimitrios C. Arhontoulis, Marc Exposit, Mohamad Abedi, Kevin M. Jude, Samer F. Halabiya, Aza Allen, Cami Cordray, Inna Goreshnik, Maggie Ahlrichs, Sidney Chan, Hillary Tunggal, Michelle DeWitt, Nathaniel Hyams, Lauren Carter, Lance Stewart, Deborah H. Fuller, Ying Mei, K. Christopher Garcia, David Baker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Cytokine release syndrome (CRS), commonly known as cytokine storm, is an acute systemic inflammatory response that is a significant global health threat. Interleukin-6 (IL-6) and interleukin-1 (IL-1) are key pro-inflammatory cytokines involv
Externí odkaz:
https://doaj.org/article/5f93a3f590e5444ea2f8d8872b6aedb3
Autor:
Nathaniel R. Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, Frank DiMaio, Steven De Munck, Savvas N. Savvides, David Baker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Recently it has become possible to de novo design high affinity protein binding proteins from target structural information alone. There is, however, considerable room for improvement as the overall design success rate is low. Here, we explo
Externí odkaz:
https://doaj.org/article/279adbbdbddf4e41bbd9f4a899f986cf
Autor:
Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M. Jude, Iva Marković, Rameshwar U. Kadam, Koen H. G. Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D. DeBouver, Allison Pires, Asim K. Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance Stewart, Ian A. Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N. Savvides, K. Christopher Garcia, David Baker
Publikováno v:
NATURE
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1–5. Here we describe a general solution to this problem that st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab523f5e18cc78b7c277b545d214fda8
https://doi.org/10.1038/s41586-022-04654-9
https://doi.org/10.1038/s41586-022-04654-9
Autor:
Brian L. Trippe, Buwei Huang, Erika A. DeBenedictis, Brian Coventry, Nicholas Bhattacharya, Kevin K. Yang, David Baker, Lorin Crawford
Publikováno v:
Protein Science. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d107d1bb0fd66d22db25ca205ccb799
https://doi.org/10.1002/pro.4401
https://doi.org/10.1002/pro.4401
Autor:
Nathaniel Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, Frank DiMaio, Steven De Munck, Savvas N. Savvides, David Baker
We explore the improvement of energy-based protein binder design using deep learning. We find that using AlphaFold2 or RoseTTAFold to assess the probability that a designed sequence adopts the designed monomer structure, and the probability that this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67ef1ed5128106ab6a3f74277fb56334
https://doi.org/10.1101/2022.06.15.495993
https://doi.org/10.1101/2022.06.15.495993
Autor:
Iva Marković, Lisa Kozodoy, Wei Yang, K. Christopher Garcia, Joon Sung Park, K. Verschueren, Samer Halabiya, Lance Stewart, Ashish Phal, Lauren Miller, Rameshwar U. Kadam, Kevin Jude, Nathaniel Bennett, Savvas N. Savvides, Steffen Benard, Brian Coventry, Lora Picton, Aerin Yang, Inna Goreshnik, David Baker, Hannele Ruohola-Baker, Kenneth Verstraete, Joseph Schlessinger, Longxing Cao, Scott T. R. Walsh, Bradley Hammerson, Michelle DeWitt, Buwei Huang, Sangwon Lee, Eva-Maria Strauch, Ian A. Wilson
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains an outstanding challenge. We describe a general solution to this problem whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e1c6f76f3ac461c48924b0145081c91
https://doi.org/10.1101/2021.09.04.459002
https://doi.org/10.1101/2021.09.04.459002
Autor:
Jie Zhuang, Seung Woo Chung, Paul M. Hwang, Xinglu Huang, Gilad Halpert, Jun Yang, Karina Negron, Justin Hanes, Xuanrong Sun, Buwei Huang, Jung Soo Suk, Yumin Oh
Publikováno v:
ACS Nano
Despite its central role in tumor progression and treatment resistance, poor vascularization that necessitates penetration of therapeutics through tumor extracellular matrix (ECM) constitutes a significant challenge to managing tumor hypoxia via conv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a785888e81f96b8a65419f8265819f5
https://pubmed.ncbi.nlm.nih.gov/30576113
https://pubmed.ncbi.nlm.nih.gov/30576113
Publikováno v:
International Journal of Nanomedicine
Ying Li,1,2 Meng Wang,1,2 Bu-Wei Huang,1,2 Yuan Ping,3 Jian You,1 Jian-Qing Gao1,2 1Institute of Pharmaceutics, College of Pharmaceutical Sciences, 2Zhejiang Province Key Laboratory of Anticancer Drug Research, College of Pharmaceutical Sciences, Zhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da91c00298e76d497b576366457e0865
https://www.dovepress.com/transcriptome-wide-elucidation-of-liposomal-formulations-for-anticance-peer-reviewed-article-IJN
https://www.dovepress.com/transcriptome-wide-elucidation-of-liposomal-formulations-for-anticance-peer-reviewed-article-IJN
Autor:
Xinglu Huang, Jie Zhuang, Seung Woo Chung, Buwei Huang, Halpert, Gilad, Negron, Karina, Xuanrong Sun, Jun Yang, Yumin Oh, Hwang, Paul M., Hanes, Justin, Jung Soo Suk
Publikováno v:
ACS Nano; 1/22/2019, Vol. 13 Issue 1, p236-247, 12p