Výsledky vyhledávání - "Butyrates/*pharmacology"

Development of a self-limiting model of methotrexate-induced mucositis reinforces butyrate as a potential therapy

Autor: da Silva Ferreira, A R, van der Aa, S A J, Wehkamp, T, Wardill, H R, Ten Klooster, J P, Garssen, J, Harthoorn, L F, Hartog, A, Harmsen, H J M, Tissing, W J E, van Bergenhenegouwen, J, Afd Pharmacology, Pharmacology

Publikováno v: Scientific Reports, 11(1), 1. NLM (Medline)
Scientific Reports
Scientific Reports, 11:22911. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific reports

Background: Gastrointestinal mucositis remains a significant complication of anticancer treatment, with limited anti-mucositis interventions. Currently, there are few validated in vitro systems suitable to study the mechanisms of mucosal injury. Ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f0be1bb49864df41a96eba18f87645
https://dspace.library.uu.nl/handle/1874/419704

Zobrazit plný text záznamu

Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3

Autor: Jin Zhang, Zhanguo Gao, Weiping Jia, Aimin Xu, Huating Li, Xin Ye, Jianping Ye

Publikováno v: Diabetes

Fibroblast growth factor 21 (FGF21) stimulates fatty acid oxidation and ketone body production in animals. In this study, we investigated the role of FGF21 in the metabolic activity of sodium butyrate, a dietary histone deacetylase (HDAC) inhibitor.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6611769b8da3912c3cf406adfaff4de
https://doi.org/10.2337/db11-0846

Zobrazit plný text záznamu

Fluorescent proteins in animal cells for process development: Optimization of sodium butyrate treatment as an example

Autor: Florian M. Wurm, Martin Jordan, Pascal Batard, L. Hunt

Publikováno v: Biotechnology and Bioengineering. 77:528-537

Fluorescent proteins expressed in mammalian cells can be quantified quickly and noninvasively with a standard fluorescence plate reader. We have previously exploited this quality in cell growth assessment (Hunt et al., 1999b). In this work, different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c9a0f09fa4c0209435875ce432c20a
https://doi.org/10.1002/bit.10108

Zobrazit plný text záznamu

Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

Autor: Graeme Milligan, Sunil K. Pandey, Brian D. Hudson, Amanda E. Mackenzie, Irina G. Tikhonova, Elisabeth Christiansen, Hannah Murdoch, Maria E Due-Hansen, Trond Ulven, Anna Mette Hansen, Richard J. Ward, Rudi Marquez

Publikováno v: The Journal of Biological Chemistry
Hudson, B D, Due-Hansen, M E, Christiansen, E, Hansen, A M, Mackenzie, A E, Murdoch, H, Pandey, S K, Ward, R J, Marquez, R, Tikhonova, I G, Ulven, T & Milligan, G 2013, ' Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor ', Journal of Biological Chemistry, vol. 288, no. 24, pp. 17296-17312 . https://doi.org/10.1074/jbc.M113.455337
Hudson, B D, Due-Hansen, M E, Christiansen, E, Hansen, A, Mackenzie, A E, Murdoch, H, Pandey, S K, Ward, R J, Marquez, R, Tikhonova, I G, Ulven, T & Milligan, G 2013, ' Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor ', Journal of Biological Chemistry, vol. 288, pp. 17296-17312 . https://doi.org/10.1074/jbc.M113.455337

Background: Understanding the function of FFA2 has been slowed by a lack of selective orthosteric ligands. Results: Residues within FFA2 that dictate the recognition and function of potent and selective orthosteric agonists are described. Conclusion:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc95593b410c8497ec6ceed8e3f6d972
https://pubmed.ncbi.nlm.nih.gov/23589301

Zobrazit plný text záznamu

Cyclic AMP and butyrate modulate melatonin synthesis in Y79 human retinoblastoma cells

Autor: Wiechmann, A. F., Kyritsis, A. P., Fletcher, R. T., Chader, G. J.

Melatonin is synthesized by cultured Y79 human retinoblastoma cells and is secreted into the medium. Activity of the two key enzymes involved in the synthesis of melatonin, N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::5f479af02232409de2d083aeb8969f7f
http://olympias.lib.uoi.gr/jspui/handle/123456789/22659

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Distribution of the regulatory subunit of type II cAMP-dependent protein kinase in Y-79 retinoblastoma cells. Effect of butyrate

Autor: Kyritsis, A. P., Kapoor, C. L., Chader, G. J.

An indirect immunofluorescence technique was employed to determine the intracellular distribution of the regulatory subunit of type II cyclic adenosine 3':5'-monophosphate-dependent protein kinase (RII) in Y-79 human retinoblastoma cells growing in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::e56d865c29b851188ece5ca44eff18de
http://olympias.lib.uoi.gr/jspui/handle/123456789/22409

Zobrazit plný text záznamu

Ultrastructural studies on cell fusion induced by Epstein-Barr virus or N-butyrate and 12-O-tetradecanoylphorbol-13-acetate. Brief report

Autor: Asai, S., Bayliss, G. J., Wolf, Hans J., Namikawa, I., Ito, Y.

The morphological changes which occur in Raji cells during EBV induced fusion are described. Of particular interest is the formation of local contacts between cells, at these points the plasmalemmae of the two cells become disorganized and cytoplasmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2ceff95ea5f176558f8efd045ca504

Zobrazit plný text záznamu

Butyrate enhances the synthesis of interphotoreceptor retinoid-binding protein (IRBP) by Y-79 human retinoblastoma cells

Autor: Kyritsis, A. P., Wiggert, B., Lee, L., Chader, G. J.

The synthesis and secretion of interphotoreceptor retinoid-binding protein (IRBP) from Y-79 human retinoblastoma cells was investigated using immunocytochemistry and SDS-polyacrylamide gel electrophoresis. Indirect immunofluorescence of cells growing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::47f04daf8f935cbadfef75a92ecb3862
http://olympias.lib.uoi.gr/jspui/handle/123456789/23362

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání