Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease.

Autor: Caffrey TM; Djavad Mowafaghian Center for Brain Health; Department of Pathology, University of British Columbia, Vancouver, BC, Canada., Button EB; Djavad Mowafaghian Center for Brain Health; Department of Pathology, University of British Columbia, Vancouver, BC, Canada., Robert J; Institute of Clinical Chemistry, University Hospital of Zurich, Zurich, Switzerland.

Publikováno v: Neural regeneration research [Neural Regen Res] 2021 Nov; Vol. 16 (11), pp. 2132-2140.

An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases.

Autor: Robert J; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada. jerome.robert@usz.ch.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada. jerome.robert@usz.ch.; Institute of Clinical Chemistry, University hospital Zurich, 8000 Zurich, Wagistrasse 14, CH-8952, Schlieren, Switzerland. jerome.robert@usz.ch., Weilinger NL; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada., Cao LP; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada.; Centre for Applied Neurogenetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada., Cataldi S; Centre for Applied Neurogenetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada., Button EB; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada., Stukas S; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada., Martin EM; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada., Seibler P; Institute of Neurogenetics, University of Luebeck, 23562, Luebeck, Germany., Gilmour M; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada., Caffrey TM; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada., Rowe EM; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada., Fan J; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada., MacVicar B; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada., Farrer MJ; Centre for Applied Neurogenetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Laboratory for Neurogenetics & Neuroscience, McKnight and Fixel Institutes, University of Florida, Gainesville, 32610, USA., Wellington CL; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada. cheryl.wellington@ubc.ca.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada. cheryl.wellington@ubc.ca.; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada. cheryl.wellington@ubc.ca.; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, V5Z 1M9, Canada. cheryl.wellington@ubc.ca.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2020 Nov 19; Vol. 15 (1), pp. 70. Date of Electronic Publication: 2020 Nov 19.

Increased severity of the CHIMERA model induces acute vascular injury, sub-acute deficits in memory recall, and chronic white matter gliosis.

Autor: Bashir A; Djavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada; Graduate Program in Neuroscience, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada. Electronic address: asma.bashir@ubc.ca., Abebe ZA; International Centre On Repair Discoveries, Department of Mechanical Engineering and School of Biomedical Engineering, University of British Columbia, Vancouver V5Z 1M9, BC, Canada., McInnes KA; International Centre On Repair Discoveries, Department of Mechanical Engineering and School of Biomedical Engineering, University of British Columbia, Vancouver V5Z 1M9, BC, Canada., Button EB; Djavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada. Electronic address: ebbutton@mail.ubc.ca., Tatarnikov I; Graduate Program in Neuroscience, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada; Centre for Applied Neurogenetics, Department of Medical Genetics, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada., Cheng WH; Djavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada., Haber M; Department of Neurology, University of Pennsylvania, 51 N 39th Street, Philadelphia, PA, USA., Wilkinson A; Djavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada. Electronic address: anna.wilkinson@ubc.ca., Barron C; Djavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada. Electronic address: cbe37@mail.ubc.ca., Diaz-Arrastia R; Department of Neurology, University of Pennsylvania, 51 N 39th Street, Philadelphia, PA, USA. Electronic address: ramon.diaz-arrastia@uphs.upenn.edu., Stukas S; Djavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada. Electronic address: sophie.stukas@ubc.ca., Cripton PA; International Centre On Repair Discoveries, Department of Mechanical Engineering and School of Biomedical Engineering, University of British Columbia, Vancouver V5Z 1M9, BC, Canada. Electronic address: cripton@mech.ubc.ca., Wellington CL; Djavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada. Electronic address: wcheryl@mail.ubc.ca.

Publikováno v: Experimental neurology [Exp Neurol] 2020 Feb; Vol. 324, pp. 113116. Date of Electronic Publication: 2019 Nov 15.

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice.

Autor: Button EB; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada.; Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada., Boyce GK; Department of Surgery, Providence Health Care Research Institute, Vancouver, BC, V6Z 1Y6, Canada., Wilkinson A; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada.; Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada., Stukas S; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada.; Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada., Hayat A; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada., Fan J; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada.; Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada., Wadsworth BJ; Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada., Robert J; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada.; Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada., Martens KM; Department of Psychology, West Virginia University, Morgantown, WV, 26506, USA., Wellington CL; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada. cheryl.wellington@ubc.ca.; Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada. cheryl.wellington@ubc.ca.

Publikováno v: Alzheimer's research & therapy [Alzheimers Res Ther] 2019 May 13; Vol. 11 (1), pp. 44. Date of Electronic Publication: 2019 May 13.

CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice.

Autor: Cheng WH; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Martens KM; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Bashir A; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Cheung H; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Stukas S; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Gibbs E; Department of Neurology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Namjoshi DR; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Button EB; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Wilkinson A; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Barron CJ; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Cashman NR; Department of Neurology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Cripton PA; Department of Mechanical Engineering, International Collaboration on Repair Discoveries, University of British Columbia, 6250 Applied Sciences Lane, Vancouver, BC, V6T 1Z4, Canada., Wellington CL; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. wcheryl@mail.ubc.ca.

Publikováno v: Alzheimer's research & therapy [Alzheimers Res Ther] 2019 Jan 12; Vol. 11 (1), pp. 6. Date of Electronic Publication: 2019 Jan 12.