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Propensity of a picornavirus polymerase to slip on potyvirus-derived transcriptional slippage sites

Autor: Stewart, Hazel, Olspert, Allan, Butt, Benjamin G, Firth, Andrew E

Publikováno v: Journal of General Virology. 100(2):199-205

The substitution rates of viral polymerases have been studied extensively. However less is known about the tendency of these enzymes to 'slip' during RNA synthesis to produce progeny RNAs with nucleotide insertions or deletions. We recently described

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496e516fc097f56d13d558a884a5e3be

Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex

Autor: Butt, Benjamin G, Owen, Danielle J, Jeffries, Cy M, Ivanova, Lyudmila, Hill, Chris H, Houghton, Jack W, Ahmed, Md Firoz, Antrobus, Robin, Svergun, Dmitri I, Welch, John J, Crump, Colin M, Graham, Stephen C

Herpesviruses acquire their membrane envelopes in the cytoplasm of infected cells via a molecular mechanism that remains unclear. Herpes simplex virus (HSV)-1 proteins pUL7 and pUL51 form a complex required for efficient virus envelopment. We show th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c528b1dc0117cec92a1155a8f148d39

Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination.

Autor: McKie SJ; Department of Clinical Neuroscience, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK., Nicholson AS; Department of Clinical Neuroscience, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK., Smith E; Department of Clinical Neuroscience, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK., Fawke S; Department of Clinical Neuroscience, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK., Caroe ER; Department of Clinical Neuroscience, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK., Williamson JC; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK., Butt BG; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK., Kolářová D; Department of Analytical Chemistry, University of Pardubice, Pardubice 53210, Czech Republic., Peterka O; Department of Analytical Chemistry, University of Pardubice, Pardubice 53210, Czech Republic., Holčapek M; Department of Analytical Chemistry, University of Pardubice, Pardubice 53210, Czech Republic., Lehner PJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK., Graham SC; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK., Deane JE; Department of Clinical Neuroscience, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Apr 04; Vol. 120 (14), pp. e2218823120. Date of Electronic Publication: 2023 Mar 30.