Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Butrus Atrash"'
Autor:
Sheelagh Frame, Chiara Saladino, Craig MacKay, Butrus Atrash, Peter Sheldrake, Edward McDonald, Paul A Clarke, Paul Workman, David Blake, Daniella Zheleva
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0234103 (2020)
Cyclin-dependent kinases (CDKs) contribute to the cancer hallmarks of uncontrolled proliferation and increased survival. As a result, over the last two decades substantial efforts have been directed towards identification and development of pharmaceu
Externí odkaz:
https://doaj.org/article/dbfd5392fe3847fb90cbeeea7636d886
Autor:
Spiros Linardopoulos, Louis Chesler, Suzanne A. Eccles, Florence I. Raynaud, Julian Blagg, Paul Workman, Simon P. Robinson, Yann Jamin, Sian Avery, Butrus Atrash, Chongbo Sun, Vassilios Bavetsias, Lynsey Vaughan, Amir Faisal
PDF file - 101K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8fb9ae57bfd3bcb6db1976abc0b02c
https://doi.org/10.1158/1535-7163.22496946.v1
https://doi.org/10.1158/1535-7163.22496946.v1
Autor:
Spiros Linardopoulos, Louis Chesler, Suzanne A. Eccles, Florence I. Raynaud, Julian Blagg, Paul Workman, Simon P. Robinson, Yann Jamin, Sian Avery, Butrus Atrash, Chongbo Sun, Vassilios Bavetsias, Lynsey Vaughan, Amir Faisal
Aurora kinases regulate key stages of mitosis including centrosome maturation, spindle assembly, chromosome segregation, and cytokinesis. Aurora A and B kinase overexpression has also been associated with various human cancers, and as such, they have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::391df8e0a377675a5359c5f05d8a88b1
https://doi.org/10.1158/1535-7163.c.6535437
https://doi.org/10.1158/1535-7163.c.6535437
Autor:
David Blake, Peter Sheldrake, Chiara Saladino, Butrus Atrash, Sheelagh Frame, Edward McDonald, Craig MacKay, Paul A. Clarke, Daniella Zheleva, Paul Workman
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0234103 (2020)
PLoS ONE
PLoS ONE
Cyclin-dependent kinases (CDKs) contribute to the cancer hallmarks of uncontrolled proliferation and increased survival. As a result, over the last two decades substantial efforts have been directed towards identification and development of pharmaceu
Autor:
Francesca L, Wood, Sam, Shepherd, Angela, Hayes, Manjuan, Liu, Katia, Grira, Yi, Mok, Butrus, Atrash, Amir, Faisal, Vassilios, Bavetsias, Spiros, Linardopoulos, Julian, Blagg, Florence I, Raynaud
Publikováno v:
European Journal of Pharmaceutical Sciences
CCT241736 is a dual fms-like tyrosine kinase 3 (FLT3)/Aurora kinase inhibitor in development for the treatment of acute myeloid leukaemia. The successful development of any new drug relies on adequate safety testing including preclinical toxicology s
Autor:
Yann-Vaï Le Bihan, Manjuan Liu, Angela Hayes, Ching Thai, Julian Blagg, Rachel M. Lanigan, Florence I. Raynaud, Butrus Atrash, Vassilios Bavetsias, Jemmy Sejberg, N. Yi Mok, Alan T. Henley
Publikováno v:
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
1. We have previously described C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as cell permeable inhibitors of the KDM4 and KDM5 subfamilies of JmjC histone lysine demethylases. 2. Although exemplar compound 1 exhibited moderate clearanc
Autor:
Akane Kawamura, Vassilios Bavetsias, Elisabeth D. Martinez, Olivia W. Rossanese, Susan Marie Westaway, Butrus Atrash, Vicki Gamble, Anthony Tumber, Susanne Müller, C. Bountra, Paul Brennan, Oleg Fedorov, Rab K. Prinjha, Udo Oppermann, Christopher J. Schofield, Gian Filippo Ruda, Stephanie B Hatch, Jack A. Brown, Clarence Yapp, Kathy Tomlin, Rachel M. Lanigan, LeAnne Carmichael, Florence I. Raynaud, Pavel Savitsky, Raquel Carvalho Montenegro, Rosemary Burke, Julian Blagg
Publikováno v:
Epigenetics & Chromatin
Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC
Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC
Background Histone lysine demethylases (KDMs) are of interest as drug targets due to their regulatory roles in chromatin organization and their tight associations with diseases including cancer and mental disorders. The first KDM inhibitors for KDM1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e858f3994a18641fd21ab8ad7cdfac8f
https://ora.ox.ac.uk/objects/uuid:5c854f9a-6888-478c-85f9-b4a155f8b999
https://ora.ox.ac.uk/objects/uuid:5c854f9a-6888-478c-85f9-b4a155f8b999
Autor:
Julian Blagg, Butrus Atrash, K. Boxall, Vassilios Bavetsias, Jessica Schmitt, Nathan J. Brown, Richard Bayliss, Sian Avery, Yolanda Pérez-Fuertes, Katherine Bush, Amar Joshi, Simon Crumpler, Spiros Linardopoulos, Rosemary Burke, Florence I. Raynaud, Chongbo Sun, Amir Faisal, Paul Workman, Alan T. Henley, Magda Kosmopoulou
Publikováno v:
Journal of Medicinal Chemistry
Aurora-A differs from Aurora-B/C at three positions in the ATP-binding pocket (L215, T217, and R220). Exploiting these differences, crystal structures of ligand-Aurora protein interactions formed the basis of a design principle for imidazo[4,5-b]pyri
Autor:
Nathan J. Brown, Edward McDonald, Jonathan M. Large, Jóhannes Reynisson, Spiros Linardopoulos, Mizio Matteucci, Butrus Atrash, Amir Faisal, Richard Bayliss, Magda Kosmopoulou, Vassilios Bavetsias, Chongbo Sun, Julian Blagg, Nathalie Bouloc
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5988-5993
Co-crystallisation of the imidazo[1,2-a]pyrazine derivative 15 (3-chloro-N-(4-morpholinophenyl)-6-(pyridin-3-yl)imidazo[1,2-a]pyrazin-8-amine) with Aurora-A provided an insight into the interactions of this class of compound with Aurora kinases. This
Autor:
Vassilios Bavetsias, Richard Bayliss, Mark W. Richards, Julian Blagg, Charlotte A. Dodson, Butrus Atrash, Magda Kosmopoulou
Publikováno v:
Biochemical Journal. 427:19-28
The production of selective protein kinase inhibitors is often frustrated by the similarity of the enzyme active sites. For this reason, it is challenging to design inhibitors that discriminate between the three Aurora kinases, which are important ta