Výsledky vyhledávání

In the Setting of Beta Cell Stress, the Pancreatic Duct Gland Transcriptome Shows Characteristics of an Activated Regenerative Response

Autor: Butler, AE, Kirakossian, D, Gurlo, T, Gao, F, Coppola, G, Butler, PC

Publikováno v: Butler, AE; Kirakossian, D; Gurlo, T; Gao, F; Coppola, G; & Butler, PC. (2018). In the Setting of Beta Cell Stress, the Pancreatic Duct Gland Transcriptome Shows Characteristics of an Activated Regenerative Response.. American journal of physiology. Gastrointestinal and liver physiology. doi: 10.1152/ajpgi.00177.2018. UCLA: Retrieved from: http://www.escholarship.org/uc/item/87z0m3pr

The pancreatic duct gland (PDG) compartment has been proposed as a potential stem cell niche based on its coiled tubular structure embedded in mesenchyme, its proliferation and expansion in response to pancreatic injury, and the fact that it contains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e53de6e7a5a87651edf1462de86f5d77
http://www.escholarship.org/uc/item/87z0m3pr

Zobrazit plný text záznamu

Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment

Autor: Ruiz, L., Gurlo, T., Ravier, Ma, Anne Wojtusciszyn, Mathieu, J., Brown, MR, Broca, C., Bertrand, G., Butler, Pc, Matveyenko, Av, Dalle, S., Costes, S.

Publikováno v: Cell Death Discovery
Cell Death Discovery, Springer Nature, 2018, 9 (6), pp.600. ⟨10.1038/s41419-018-0603-0⟩
Cell death & disease, vol 9, iss 6
Cell Death & Disease
Cell Death Discovery, 2018, 9 (6), pp.600. ⟨10.1038/s41419-018-0603-0⟩
BASE-Bielefeld Academic Search Engine
Ruiz, L; Gurlo, T; Ravier, MA; Wojtusciszyn, A; Mathieu, J; Brown, MR; et al.(2018). Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. CELL DEATH & DISEASE, 9. doi: 10.1038/s41419-018-0603-0. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9894r9hv
Cell Death and Disease, Vol 9, Iss 6, Pp 1-12 (2018)
Cell Death Dis, vol. 9, no. 6, pp. 600

International audience; In type 2 diabetes, amyloid oligomers, chronic hyperglycemia, lipotoxicity, and pro-inflammatory cytokines are detrimental to beta-cells, causing apoptosis and impaired insulin secretion. The histone acetyl transferase p300, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::37b23853e8fe19449b6ad632d948a168
https://hal.archives-ouvertes.fr/hal-02320439/file/pdfjoiner.pdf

Zobrazit plný text záznamu

CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced beta-Cell Apoptosis

Autor: Gurlo, T, Rivera, JF, Butler, AE, Cory, M, Hoang, J, Costes, S, Butler, PC

Publikováno v: Gurlo, T; Rivera, JF; Butler, AE; Cory, M; Hoang, J; Costes, S; et al.(2016). CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced beta-Cell Apoptosis. MOLECULAR ENDOCRINOLOGY, 30(4), 446-454. doi: 10.1210/me.2015-1255. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8rr0h6fd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::ad922d3f4a9721bea94b10cad9b7b915
http://www.escholarship.org/uc/item/8rr0h6fd

Zobrazit plný text záznamu

beta-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of beta-Cell Dedifferentiation and Degranulation

Autor: Butler, AE, Dhawan, S, Hoang, J, Cory, M, Zeng, K, Fritsch, H, Meier, JJ, Rizza, RA, Butler, PC

Publikováno v: Butler, AE; Dhawan, S; Hoang, J; Cory, M; Zeng, K; Fritsch, H; et al.(2016). beta-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of beta-Cell Dedifferentiation and Degranulation. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 101(2), 523-532. doi: 10.1210/jc.2015-3566. UCLA: Retrieved from: http://www.escholarship.org/uc/item/68n4p08b

Type 2 diabetes is characterized by a β-cell deficit and a progressive defect in β-cell function. It has been proposed that the deficit in β-cells may be due to β-cell degranulation and transdifferentiation to other endocrine cell types.The objec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::10d03a314957631b281d9c6cc6733984
http://www.escholarship.org/uc/item/68n4p08b

Zobrazit plný text záznamu

Islet Inflammation: A Causal Link Between Diabetes and Pancreatic Cancer?

Autor: Butler, PC

Publikováno v: JOP : Journal of the pancreas, vol 15, iss 5
Butler, PC. (2014). Islet inflammation: a causal link between diabetes and pancreatic cancer?. JOP : Journal of the pancreas, 15(5), 2774. doi: 10.6092/1590-8577/2774. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1zq4m5km

Type 2 diabetes (T2DM) is characterized hyperglycemia due to impaired insulin secretion and a deficit of pancreatic beta cells in the setting of insulin resistance. Most individuals are able to compensate for insulin resistance by increasing insulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ceffe833bf6f98b3edc02eede946c1d

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání