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Orchestration of Tryptophan-Kynurenine Pathway, Acute Decompensation, and Acute-on-Chronic Liver Failure in Cirrhosis

Autor: Claria, J., Moreau, R., Fenaille, F., Amoros, A., Junot, C., Gronbaek, H., Coenraad, M.J., Pruvost, A., Ghettas, A., Chu-Van, E., Lopez-Vicario, C., Oettl, K., Caraceni, P., Alessandria, C., Trebicka, J., Pavesi, M., Deulofeu, C., Albillos, A., Gustot, T., Welzel, T.M., Fernandez, J., Stauber, R.E., Saliba, F., Butin, N., Colsch, B., Moreno, C., Durand, F., Nevens, F., Banares, R., Benten, D., Gines, P., Gerbes, A., Jalan, R., Angeli, P., Bernardi, M., Arroyo, V., EASL Clif Consortium, Grifols Chair European Fdn Study C

Publikováno v: Clària, J, Moreau, R, Fenaille, F, Amorós, A, Junot, C, Gronbaek, H, Coenraad, M J, Pruvost, A, Ghettas, A, Chu-Van, E, López-Vicario, C, Oettl, K, Caraceni, P, Alessandria, C, Trebicka, J, Pavesi, M, Deulofeu, C, Albillos, A, Gustot, T, Welzel, T M, Fernández, J, Stauber, R E, Saliba, F, Butin, N, Colsch, B, Moreno, C, Durand, F, Nevens, F, Bañares, R, Benten, D, Ginès, P, Gerbes, A, Jalan, R, Angeli, P, Bernardi, M, Arroyo, V & CANONIC Study Investigators of the EASL Clif Consortium Grifols Chair and the European Foundation for the Study of Chronic Liver Failure (EF Clif) 2019, ' Orchestration of Tryptophan-Kynurenine pathway, acute decompensation and acute-on-chronic liver failure in cirrhosis ', Hepatology, vol. 69, no. 4, pp. 1686-1701 . https://doi.org/10.1002/hep.30363
Hepatology, 69(4), 1686-1701
Hepatology
Hepatology, Wiley-Blackwell, 2019, 69 (4), pp.1686-1701. ⟨10.1002/hep.30363⟩
Hepatology, 69 (4
Hepatology, 2019, 69 (4), pp.1686-1701. ⟨10.1002/hep.30363⟩

Systemic inflammation (SI) is involved in the pathogenesis of acute decompensation (AD) and acute-on-chronic liver failure (ACLF) in cirrhosis. In other diseases, SI activates tryptophan (Trp) degradation through the kynurenine pathway (KP), giving r

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