Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction.

Autor: García RA; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA.; Department of Medicine, University of California-San Diego, San Diego, California, USA., Lupisella JA; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Ito BR; Department of Medicine, University of California-San Diego, San Diego, California, USA., Hsu MY; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Fernando G; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Carson NL; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Allocco JJ; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Ryan CS; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Zhang R; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Wang Z; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Heroux M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada., Carrier M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada., St-Onge S; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada., Bouvier M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada., Dudhgaonkar S; Biocon Bristol Myers Squibb Research Center, Bangalore, India., Nagar J; Biocon Bristol Myers Squibb Research Center, Bangalore, India., Bustamante-Pozo MM; Department of Medicine, University of California-San Diego, San Diego, California, USA., Garate-Carrillo A; Department of Medicine, University of California-San Diego, San Diego, California, USA., Chen J; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Ma X; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Search DJ; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Dierks EA; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Kick EK; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Wexler RR; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Gordon DA; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Ostrowski J; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Wurtz NR; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Villarreal F; Department of Medicine, University of California-San Diego, San Diego, California, USA.

Publikováno v: JACC. Basic to translational science [JACC Basic Transl Sci] 2021 Aug 23; Vol. 6 (8), pp. 676-689. Date of Electronic Publication: 2021 Aug 23 (Print Publication: 2021).

The role of inflammation in driving left ventricular remodeling in a pre-HFpEF model.

Autor: Loredo-Mendoza ML; Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico 07738, Mexico.; Department of Histopathology, School of Medicine, Universidad Panamericana, Ciudad de Mexico 03920, Mexico., Ramirez-Sanchez I; Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico 07738, Mexico.; Department of Medicine, School of Medicine, University of California, San Diego, CA 92093-0021, USA., Bustamante-Pozo MM; Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico 07738, Mexico.; Department of Medicine, School of Medicine, University of California, San Diego, CA 92093-0021, USA., Ayala M; Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico 07738, Mexico., Navarrete V; Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico 07738, Mexico., Garate-Carrillo A; Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico 07738, Mexico.; Department of Medicine, School of Medicine, University of California, San Diego, CA 92093-0021, USA., Ito BR; Department of Medicine, School of Medicine, University of California, San Diego, CA 92093-0021, USA., Ceballos G; Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico 07738, Mexico., Omens J; Department of Medicine, School of Medicine, University of California, San Diego, CA 92093-0021, USA., Villarreal F; Department of Medicine, School of Medicine, University of California, San Diego, CA 92093-0021, USA.; VA San Diego Healthcare, San Diego, CA 92161, USA.

Publikováno v: Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2020 Apr; Vol. 245 (8), pp. 748-757. Date of Electronic Publication: 2020 Mar 17.