Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Busra, Gurel"'
Publikováno v:
Scientia Pharmaceutica, Vol 91, Iss 3, p 31 (2023)
Alterations in the biological activity of the molecules under stress conditions have not been documented as widely in the literature yet. This study was designed to reveal the functional impacts of various oxidation conditions on a model mAb, a comme
Externí odkaz:
https://doaj.org/article/52f4e920895f4a83ba61c186d14d99bf
Autor:
Busra Gurel, Melike Berksoz, Eda Capkin, Ayhan Parlar, Meltem Corbacioglu Pala, Aylin Ozkan, Yılmaz Capan, Duygu Emine Daglikoca, Meral Yuce
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1571 (2022)
Avastin® is a humanized recombinant monoclonal antibody used to treat cancer by targeting VEGF-A to inhibit angiogenesis. SIMAB054, an Avastin® biosimilar candidate developed in this study, showed a different charge variant profile than its innovat
Externí odkaz:
https://doaj.org/article/d639b8ba82f649c6b9f86058a8458ef5
Autor:
Eda Capkin, Hasan Kurt, Busra Gurel, Dilan Bicak, Sibel Akgun Bas, Duygu Emine Daglikoca, Meral Yuce
Publikováno v:
Langmuir. 38:14623-14634
Fc γreceptors (FcγRs) are one of the structures that can initiate effector function for monoclonal antibodies. FcγRIa has the highest affinity toward IgG1-type monoclonal antibodies among all FcγRs. In this study, a comprehensive characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d094269bfe242eb9392dde01da77d3d
https://doi.org/10.1021/acs.langmuir.2c02022
https://doi.org/10.1021/acs.langmuir.2c02022
Publikováno v:
Scientia Pharmaceutica; Volume 91; Issue 3; Pages: 31
Alterations in the biological activity of the molecules under stress conditions have not been documented as widely in the literature yet. This study was designed to reveal the functional impacts of various oxidation conditions on a model mAb, a comme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::42f7444aaa318e8ed719705540b22505
Autor:
Busra Gurel, Julide Coskun, Ahmet Tarik Baykal, Merve Karayel Basar, Irem Kiris, Tomasz Mroczek, Betul Sahin
Publikováno v:
Current Medicinal Chemistry. 28:3449-3473
Background:: Alzheimer’s disease is one of the leading health problems characterized by the accumulation of Aβ and hyperphosphorylated tau that account for the senile plaque formations causing extensive cognitive decline. Many of the clinical diag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f39d3445986af75f467132b6cfdb96
https://doi.org/10.2174/0929867327999201116193126
https://doi.org/10.2174/0929867327999201116193126
Autor:
Irem Kiris, Wirginia Kukula-Koch, Merve Karayel-Basar, Busra Gurel, Julide Coskun, Ahmet Tarik Baykal
Publikováno v:
Biomedicine & Pharmacotherapy. 158:114111
Alzheimer's disease (AD) is one of the most prevalent diseases that lead to memory deficiencies, severe behavioral abnormalities, and ultimately death. The need for more appropriate treatment of AD continues, and remains a sought-after goal. Previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231517ec72c12fee85f0c18677c84730
https://doi.org/10.1016/j.biopha.2022.114111
https://doi.org/10.1016/j.biopha.2022.114111
Autor:
Emel Akgun, Betul Sahin, Mete Bora Tuzuner, Zelal Adiguzel, Muge Serhatli, Cigdem Acioglu, Busra Gurel, Ahmet Tarik Baykal, Ceyda Acilan
Publikováno v:
Current Proteomics. 16:136-147
Background and Objective: Antimycin A (AntA) is a potent Electron Transport System (ETS) inhibitor exerting its effect through inhibiting the transfer of the electrons by binding to the quinone reduction site of the cytochrome bc1 complex (Complex II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf1dc38e44d7bcf2f1e2c68eed2b509c
https://doi.org/10.2174/1570164615666180713110139
https://doi.org/10.2174/1570164615666180713110139
Autor:
Meral Yüce, Ayhan Parlar, Prabir Kumar Kulabhusan, Başak Özata, Milad Torabfam, Busra Gurel, Hasan Kurt
Publikováno v:
Drug Delivery with Targeted Nanoparticles ISBN: 9781003164739
Drug Delivery with Targeted Nanoparticles
Drug Delivery with Targeted Nanoparticles
Drug-loaded nanoparticles have many advantages in drug administration, which is an essential step for the impact of the drugs and their mechanism of action. Circular dichroism (CD) is a spectroscopy technique that measures the absorbance difference b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04795b2123f37673da05ba2368eb453
https://hdl.handle.net/20.500.12511/9372
https://hdl.handle.net/20.500.12511/9372
Autor:
Meral Yüce, Mansoor A. Khan, Fatma Sert, Nilüfer Çakır, Busra Gurel, Ayhan Parlar, Milad Torabfam, Duygu E. Dağlıkoca, Yilmaz Capan
Publikováno v:
Analytica chimica acta. 1152
The similarity between originator and biosimilar monoclonal antibody candidates are rigorously assessed based on primary, secondary, tertiary, quaternary structures, and biological functions. Minor differences in such parameters may alter target-bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cea1f320e3c8e4b50879be010c20e31
https://pubmed.ncbi.nlm.nih.gov/33648647
https://pubmed.ncbi.nlm.nih.gov/33648647
Autor:
Zerrin Karaaslan, Mete Bora Tuzuner, Cem İsmail Küçükali, Mefkure Eraksoy, Erdem Tüzün, Ahmet Tarik Baykal, Tuncay Gündüz, Busra Gurel, Ozlem Timirci-Kahraman, Murat Kürtüncü, Emel Akgun
Publikováno v:
Acta Neurologica Belgica. 119:101-111
Multiple sclerosis (MS) often starts in the form of clinically isolated syndrome (CIS) and only some of the CIS patients progress to relapsing-remitting MS (RRMS). Biomarkers to predict conversion from CIS to MS are thus greatly needed for making cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37deb0923df66c170ace9a4f0ca8ecf
https://doi.org/10.1007/s13760-018-0954-4
https://doi.org/10.1007/s13760-018-0954-4