Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis in vitro

Autor: Hurrish, Katie H., Su, Yongwei, Patel, Shraddha, Ramage, Cassandra L., Zhao, Jianlei, Temby, Brianna R., Carter, Jenna L., Edwards, Holly, Buck, Steven A., Wiley, Sandra E., Hüttemann, Maik, Polin, Lisa, Kushner, Juiwanna, Dzinic, Sijana H., White, Kathryn, Bao, Xun, Li, Jing, Yang, Jay, Boerner, Julie, Hou, Zhanjun, Al-Atrash, Gheath, Konoplev, Sergej N., Busquets, Jonathan, Tiziani, Stefano, Matherly, Larry H., Taub, Jeffrey W., Konopleva, Marina, Ge, Yubin, Baran, Natalia

Publikováno v: In Biochemical Pharmacology February 2024 220

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Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis.

Autor: Hurrish KH; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI 48201, USA., Su Y; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Patel S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ramage CL; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Carter JL; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI 48201, USA.; MD/PhD Program, Wayne State University School of Medicine, Detroit, MI 48201, USA., Edwards H; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Buck SA; Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI 48201, USA., Wiley SE; MEI Pharma, Inc., San Diego, CA 92130, USA., Hüttemann M; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA., Polin L; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Kushner J; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Dzinic SH; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., White K; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Bao X; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Li J; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Yang J; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Boerner J; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Hou Z; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Al-Atrash G; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Konoplev SN; Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA., Busquets J; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78712, USA., Tiziani S; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78712, USA., Matherly LH; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Taub JW; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI 48201, USA.; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA., Konopleva M; Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA., Ge Y; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA., Baran N; Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA.

Publikováno v: Research square [Res Sq] 2023 Apr 28. Date of Electronic Publication: 2023 Apr 28.