Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Busolo Wabuyele"'
Publikováno v:
Organic Process Research & Development. 24:1665-1674
Distillation processes with several solid-state phases and dynamic multicomponent liquid-phase compositions can be challenging to understand and scale up because of complexity of the thermodynamics...
Autor:
Shane T. Grosser, Angela Spartalis, John Higgins, George Zhou, Gabriel C. Graffius, Cindy Starbuck, Busolo Wabuyele, Aaron Moment, Paul Fernandez, Lei Sun, Ganeshwar Prasad
Publikováno v:
Organic Process Research & Development. 20:653-660
The transamination-chemistry-based process for sitagliptin is a through-process, which challenges the crystallization of the active pharmaceutical ingredient (API) in a batch stream composed of multiple components. Risk-assessment-based design of exp
Autor:
Effendi Widjaja, Busolo Wabuyele, Xiaodun Mou, Mohammed Shameem, Geetha Thiagarajan, Jason K. Cheung, Jun Hyuk Heo
Publikováno v:
Journal of Raman Spectroscopy. 46:531-536
Structural complexity of biological drug products presents an analytical challenge in terms of early detection of aggregation and/or degradation. In the present study, Raman and Raman optical activity (ROA) were evaluated for their sensitivity to det
Publikováno v:
Journal of pharmaceutical sciences. 106(2)
Process-induced inadvertent phase change of an active pharmaceutical ingredient in a drug product could impact chemical stability, physical stability, shelf life, and bioperformance. In this study, dispersive Raman spectroscopy is presented as an alt
Publikováno v:
Analytica Chimica Acta. 611:143-150
Near-infrared calibration models were developed for the determination of content uniformity of pharmaceutical tablets containing 29.4% drug load for two dosage strengths (X and Y). Both dosage strengths have a circular geometry and the only differenc
Publikováno v:
Vibrational Spectroscopy. 46:128-134
This paper presents an application of near-infrared (NIR) multivariate calibration for the determination of content uniformity of pharmaceutical tablets. Data used in this study were acquired from 3 NIR instruments obtained from 2 different vendors.
Publikováno v:
Applied Spectroscopy. 55:307-310
The fluorescence emission of the fluoranthene molecule has been investigated at excitation wavelengths varying from 240 to 360 nm, and conducted from near collision-free conditions to atmosphericpressure conditions. The oxygen quenching rate for the
Publikováno v:
The Analyst. 134(7)
Robust NIR transmission spectroscopic methods have been developed for determination of content uniformity (CU) of pharmaceutical products with a complex tablet matrix. The tablets of interest, formulated with eight components with active drug load of
Autor:
Robbe C. Lyon, Huiquan Wu, Ajaz S. Hussain, Dong Xiang, Joseph Berry, Mansoor A. Khan, Busolo Wabuyele, James Cheney, Rosario LoBrutto
Publikováno v:
Applied spectroscopy. 63(1)
This paper examines how one may assess spectral changes with instrument configuration (or composition), in combination with the spectral changes in the measurement that are caused by experimental effects, and subsequently select an appropriate measur
Autor:
James Cheney, Joseph Berry, Mazen Hamed, Ajaz S. Hussain, Yatindra Joshi, Busolo Wabuyele, Susan Buntz, Huiquan Wu, Mansoor A. Khan, Dong Xiang, Paul M. Gargiulo
Publikováno v:
Journal of pharmaceutical sciences. 98(3)
Quantification analysis with near-infrared (NIR) spectroscopy typically requires utilizing chemometric techniques, such as partial least squares (PLS) method, to achieve the desired selectivity. This article points out a major limitation of these sta